comt Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description catechol-O-methyltransferase|Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008] (NCBI Entrez Gene Database, 1312)
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Genes

70 genes co-occuring with the biological term comt in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADRA2B adrenoceptor alpha 2B
AKT1 v-akt murine thymoma viral oncogene homolog 1
ANKK1 ankyrin repeat and kinase domain containing 1
APOE apolipoprotein E
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
BDNF brain-derived neurotrophic factor
CAT catalase
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal)
CNR1 cannabinoid receptor 1 (brain)
COMT catechol-O-methyltransferase
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DAOA D-amino acid oxidase activator
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase)
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DISC1 disrupted in schizophrenia 1
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DRD4 dopamine receptor D4
DRD5 dopamine receptor D5
DTNBP1 dystrobrevin binding protein 1
EGFR epidermal growth factor receptor
EP300 E1A binding protein p300
ERCC2 excision repair cross-complementation group 2
ESR1 estrogen receptor 1
FOS FBJ murine osteosarcoma viral oncogene homolog
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GPT glutamic-pyruvate transaminase (alanine aminotransferase)
GRK5 G protein-coupled receptor kinase 5
GRM3 glutamate receptor, metabotropic 3
HFE hemochromatosis
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
IL10 interleukin 10
MAOA monoamine oxidase A
MAOB monoamine oxidase B
MKL1 megakaryoblastic leukemia (translocation) 1
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRG1 neuregulin 1
OPRM1 opioid receptor, mu 1
PNMT phenylethanolamine N-methyltransferase
POR P450 (cytochrome) oxidoreductase
PPARG peroxisome proliferator-activated receptor gamma
PRODH proline dehydrogenase (oxidase) 1
PRSS16 protease, serine, 16 (thymus)
RGS4 regulator of G-protein signaling 4
SHBG sex hormone-binding globulin
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TPH1 tryptophan hydroxylase 1
TPH2 tryptophan hydroxylase 2
TPMT thiopurine S-methyltransferase
TXNRD2 thioredoxin reductase 2
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7
ZNF804A zinc finger protein 804A