cop9 signalosome Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome. (Gene Ontology, GO_0008180)
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Genes

246 proteins co-occuring with the cop9 signalosome cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
COPS5 COP9 signalosome subunit 5 2.8783
CUL1 cullin 1 1.79442
BCL10 B-cell CLL/lymphoma 10 1.7432
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 1.67386
MALT1 MALT1 paracaspase 1.62413
CAND1 cullin-associated and neddylation-dissociated 1 1.48023
USP15 ubiquitin specific peptidase 15 1.41138
COPS2 COP9 signalosome subunit 2 1.2777
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 1.25864
COPS3 COP9 signalosome subunit 3 1.21946
CUL4A cullin 4A 1.19931
SKP1 S-phase kinase-associated protein 1 1.15262
DDB1 damage-specific DNA binding protein 1, 127kDa 1.11786
SNN stannin 1.10715
RBX1 ring-box 1, E3 ubiquitin protein ligase 1.08577
GPR146 G protein-coupled receptor 146 1.06246
BLNK B-cell linker 1.02181
ITPK1 inositol-tetrakisphosphate 1-kinase 1.01337
LAT linker for activation of T cells 1.00744
LYN LYN proto-oncogene, Src family tyrosine kinase 1.00497
CUL3 cullin 3 1.00202
BCR breakpoint cluster region 0.998577
COPS7A COP9 signalosome subunit 7A 0.993672
JUN jun proto-oncogene 0.984393
GPR160 G protein-coupled receptor 160 0.963588
PMF1 polyamine-modulated factor 1 0.951142
BTK Bruton agammaglobulinemia tyrosine kinase 0.938795
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 0.938322
PARK2 parkin RBR E3 ubiquitin protein ligase 0.936432
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase 0.922322
SENP8 SUMO/sentrin specific peptidase family member 8 0.913909
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.90321
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.89348
MPND MPN domain containing 0.822664
DDB2 damage-specific DNA binding protein 2, 48kDa 0.810276
SYK spleen tyrosine kinase 0.809359
GPR107 G protein-coupled receptor 107 0.804772
RGS13 regulator of G-protein signaling 13 0.789649
LRP6 low density lipoprotein receptor-related protein 6 0.786902
IQCH IQ motif containing H 0.775928
THEMIS thymocyte selection associated 0.765438
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) 0.763617
NUB1 negative regulator of ubiquitin-like proteins 1 0.759069
MLF1 myeloid leukemia factor 1 0.75181
TRIM14 tripartite motif containing 14 0.746381
CARD11 caspase recruitment domain family, member 11 0.745929
AZI2 5-azacytidine induced 2 0.744574
TP53 tumor protein p53 0.743671
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 0.72258
MYEOV2 myeloma overexpressed 2 0.716791
AXIN1 axin 1 0.71457
TICAM1 toll-like receptor adaptor molecule 1 0.713682
TSPAN6 tetraspanin 6 0.703067
COPS8 COP9 signalosome subunit 8 0.703067
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.699983
GRB2 growth factor receptor-bound protein 2 0.696905
FUS FUS RNA binding protein 0.693832
CUL4B cullin 4B 0.692955
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.689013
CUL2 cullin 2 0.68639
VAV1 vav 1 guanine nucleotide exchange factor 0.681591
MAP3K6 mitogen-activated protein kinase kinase kinase 6 0.679849
TMEM102 transmembrane protein 102 0.674196
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.672026
ITK IL2-inducible T-cell kinase 0.669425
COPS6 COP9 signalosome subunit 6 0.664664
DCAF11 DDB1 and CUL4 associated factor 11 0.658188
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.656033
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.655602
MAVS mitochondrial antiviral signaling protein 0.65001
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.647862
NIF3L1 NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae) 0.647003
KCTD6 potassium channel tetramerization domain containing 6 0.641429
MLF2 myeloid leukemia factor 2 0.634159
UBE2M ubiquitin-conjugating enzyme E2M 0.634159
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 0.633732
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) 0.621804
MAPK13 mitogen-activated protein kinase 13 0.617133
DDA1 DET1 and DDB1 associated 1 0.611625
MAPK12 mitogen-activated protein kinase 12 0.607395
PRKD1 protein kinase D1 0.595173
SKAP1 src kinase associated phosphoprotein 1 0.583431
CD40 CD40 molecule, TNF receptor superfamily member 5 0.575078
TNFRSF4 tumor necrosis factor receptor superfamily, member 4 0.572162
STOML2 stomatin (EPB72)-like 2 0.568416
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 0.557214
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 0.552251
LCK LCK proto-oncogene, Src family tyrosine kinase 0.544823
GAPT GRB2-binding adaptor protein, transmembrane 0.542764
STAMBP STAM binding protein 0.532488
GAB1 GRB2-associated binding protein 1 0.530028
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 0.527569
USP12 ubiquitin specific peptidase 12 0.527569
NRBP1 nuclear receptor binding protein 1 0.525522
TRAF3 TNF receptor-associated factor 3 0.523067
UBXN1 UBX domain protein 1 0.521432
LRP5 low density lipoprotein receptor-related protein 5 0.520615
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.514085
MEMO1 mediator of cell motility 1 0.510826
EIF3E eukaryotic translation initiation factor 3, subunit E 0.509604
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 0.50879
DDRGK1 DDRGK domain containing 1 0.505537
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 0.502693
EIF3H eukaryotic translation initiation factor 3, subunit H 0.499042
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.497826
ARRB2 arrestin, beta 2 0.497015
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 0.492561
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.488923
ECE1 endothelin converting enzyme 1 0.488923
FBXW4 F-box and WD repeat domain containing 4 0.484886
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 0.480855
CLEC1B C-type lectin domain family 1, member B 0.47844
PDE3B phosphodiesterase 3B, cGMP-inhibited 0.476429
CLOCK clock circadian regulator 0.472813
GPS1 G protein pathway suppressor 1 0.461199
CARD10 caspase recruitment domain family, member 10 0.459203
DUSP5 dual specificity phosphatase 5 0.455613
GAB2 GRB2-associated binding protein 2 0.453621
TESC tescalcin 0.451631
CCND2 cyclin D2 0.451631
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.446862
WNT3A wingless-type MMTV integration site family, member 3A 0.442104
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 0.434591
RXFP1 relaxin/insulin-like family peptide receptor 1 0.427891
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.425924
FYB FYN binding protein 0.424353
TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B) 0.421997
IP6K1 inositol hexakisphosphate kinase 1 0.418468
CARD9 caspase recruitment domain family, member 9 0.418468
ZNRF3 zinc and ring finger 3 0.414555
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase 0.408309
SF3B3 splicing factor 3b, subunit 3, 130kDa 0.402859
USP11 ubiquitin specific peptidase 11 0.401693
PLCG1 phospholipase C, gamma 1 0.397035
TOLLIP toll interacting protein 0.389296
TBATA thymus, brain and testes associated 0.387365
TEC tec protein tyrosine kinase 0.386979
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.386208
XAB2 XPA binding protein 2 0.383124
CDK14 cyclin-dependent kinase 14 0.380814
IRAK1 interleukin-1 receptor-associated kinase 1 0.380045
FZD1 frizzled class receptor 1 0.378891
PDLIM2 PDZ and LIM domain 2 (mystique) 0.375434
TRADD TNFRSF1A-associated via death domain 0.375434
CLCF1 cardiotrophin-like cytokine factor 1 0.368919
MAPK8 mitogen-activated protein kinase 8 0.366623
DVL1 dishevelled segment polarity protein 1 0.363949
ARRB1 arrestin, beta 1 0.360515
CHUK conserved helix-loop-helix ubiquitous kinase 0.353662
CIB1 calcium and integrin binding 1 (calmyrin) 0.350622
PIAS4 protein inhibitor of activated STAT, 4 0.347967
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.347587
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 0.347208
CD40LG CD40 ligand 0.344935
EIF3M eukaryotic translation initiation factor 3, subunit M 0.343799
TOM1L2 target of myb1-like 2 (chicken) 0.341151
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 0.340773
MAP2K7 mitogen-activated protein kinase kinase 7 0.339261
TREX2 three prime repair exonuclease 2 0.336996
USP33 ubiquitin specific peptidase 33 0.333602
LARS leucyl-tRNA synthetase 0.325327
TRAF2 TNF receptor-associated factor 2 0.323825
DKK2 dickkopf WNT signaling pathway inhibitor 2 0.323075
MED10 mediator complex subunit 10 0.321201
KREMEN1 kringle containing transmembrane protein 1 0.31596
DVL2 dishevelled segment polarity protein 2 0.314091
VRK2 vaccinia related kinase 2 0.306632
MIF4GD MIF4G domain containing 0.302912
LIN28B lin-28 homolog B (C. elegans) 0.301425
CD4 CD4 molecule 0.301054
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 0.297713
ZMYND11 zinc finger, MYND-type containing 11 0.29586
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.292157
GFER growth factor, augmenter of liver regeneration 0.289938
RNF139 ring finger protein 139 0.288091
CD209 CD209 molecule 0.286245
A1BG alpha-1-B glycoprotein 0.286245
CDT1 chromatin licensing and DNA replication factor 1 0.27998
DISC1 disrupted in schizophrenia 1 0.27998
RNF43 ring finger protein 43 0.276671
CSN3 casein kappa 0.276304
MYD88 myeloid differentiation primary response 88 0.276304
MAPK9 mitogen-activated protein kinase 9 0.274835
CLEC4C C-type lectin domain family 4, member C 0.273
AKAP1 A kinase (PRKA) anchor protein 1 0.265311
CLEC4A C-type lectin domain family 4, member A 0.26385
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) 0.26239
AK6 adenylate kinase 6 0.260566
SIAH1 siah E3 ubiquitin protein ligase 1 0.259473
CDK2 cyclin-dependent kinase 2 0.259473
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.256925
BRCA2 breast cancer 2, early onset 0.256925
UXT ubiquitously-expressed, prefoldin-like chaperone 0.256561
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.246046
RNF31 ring finger protein 31 0.243879
CREB3 cAMP responsive element binding protein 3 0.23776
GPR182 G protein-coupled receptor 182 0.235966
SPOP speckle-type POZ protein 0.235249
CENPW centromere protein W 0.235249
TNIK TRAF2 and NCK interacting kinase 0.231315
EIF3K eukaryotic translation initiation factor 3, subunit K 0.230245
AKAP5 A kinase (PRKA) anchor protein 5 0.230245
UBE2S ubiquitin-conjugating enzyme E2S 0.22173
HPSE2 heparanase 2 (inactive) 0.221378
HCLS1 hematopoietic cell-specific Lyn substrate 1 0.220321
ADRA1D adrenoceptor alpha 1D 0.218914
PTAFR platelet-activating factor receptor 0.214366
TCAP titin-cap 0.207108
POU3F2 POU class 3 homeobox 2 0.204378
BCAR1 breast cancer anti-estrogen resistance 1 0.202346
SCN10A sodium channel, voltage gated, type X alpha subunit 0.197993
VPRBP Vpr (HIV-1) binding protein 0.197993
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 0.196669
CTNND1 catenin (cadherin-associated protein), delta 1 0.195681
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.191777
ELMO1 engulfment and cell motility 1 0.191777
ADRBK1 adrenergic, beta, receptor kinase 1 0.189857
ASCL1 achaete-scute family bHLH transcription factor 1 0.189539
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.189222
STOM stomatin 0.18516
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 0.184853
USP4 ubiquitin specific peptidase 4 (proto-oncogene) 0.183025
ALK anaplastic lymphoma receptor tyrosine kinase 0.181823
EIF3F eukaryotic translation initiation factor 3, subunit F 0.181524
TTN titin 0.18093
NOD1 nucleotide-binding oligomerization domain containing 1 0.180634
MKKS McKusick-Kaufman syndrome 0.178299
LAT2 linker for activation of T cells family, member 2 0.177439
DBNL drebrin-like 0.175466
CACYBP calcyclin binding protein 0.174087
TNF tumor necrosis factor 0.172735
BRAP BRCA1 associated protein 0.170888
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.167856
CPB1 carboxypeptidase B1 (tissue) 0.167611
TNFRSF25 tumor necrosis factor receptor superfamily, member 25 0.165697
CREB3L4 cAMP responsive element binding protein 3-like 4 0.165231
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.164089
GPR135 G protein-coupled receptor 135 0.162763
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 0.160456
TRAF5 TNF receptor-associated factor 5 0.160254
PBK PDZ binding kinase 0.160053
DOCK2 dedicator of cytokinesis 2 0.158882
MAPRE1 microtubule-associated protein, RP/EB family, member 1 0.158692
STK3 serine/threonine kinase 3 0.157218
BCL2A1 BCL2-related protein A1 0.156513
E2F5 E2F transcription factor 5, p130-binding 0.156342