cortisol Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A C21-steroid that is pregn-4-ene substituted by oxo groups at positions 3 and 20 and hydroxy groups at positions 11, 17 and 21. Cortisol is a corticosteroid hormone or glucocorticoid produced by zona fasciculata of the adrenal cortex, which is a part of the adrenal gland. It is usually referred to as the stress hormone as it is involved in response to stress and anxiety, controlled by corticotropin-releasing hormone (CRH). It increases blood pressure and blood sugar, and reduces immune responses (Chemical Entities of Biological Interest Ontology, CHEBI_17650)
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Genes

117 genes co-occuring with the biological term cortisol in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACE angiotensin I converting enzyme
ADIPOQ adiponectin, C1Q and collagen domain containing
ADRB2 adrenoceptor beta 2, surface
AGRP agouti related neuropeptide
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR2 angiotensin II receptor, type 2
AMY1A amylase, alpha 1A (salivary)
ANXA1 annexin A1
APOE apolipoprotein E
APP amyloid beta (A4) precursor protein
AR androgen receptor
ARNTL aryl hydrocarbon receptor nuclear translocator-like
AVP arginine vasopressin
BDNF brain-derived neurotrophic factor
CBR1 carbonyl reductase 1
CCKBR cholecystokinin B receptor
CGA glycoprotein hormones, alpha polypeptide
CHGA chromogranin A
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal)
CLOCK clock circadian regulator
COMT catechol-O-methyltransferase
CREB1 cAMP responsive element binding protein 1
CRH corticotropin releasing hormone
CRHBP corticotropin releasing hormone binding protein
CRHR1 corticotropin releasing hormone receptor 1
CRP C-reactive protein, pentraxin-related
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2
CYP3A cytochrome P450, family 3, subfamily A
DIAPH1 diaphanous-related formin 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DRD4 dopamine receptor D4
ELANE elastase, neutrophil expressed
EP300 E1A binding protein p300
FKBP5 FK506 binding protein 5
FMR1 fragile X mental retardation 1
GALR1 galanin receptor 1
GH1 growth hormone 1
GHRH growth hormone releasing hormone
GHRL ghrelin/obestatin prepropeptide
GNAS GNAS complex locus
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
IAPP islet amyloid polypeptide
IFNB1 interferon, beta 1, fibroblast
IFNL3 interferon, lambda 3
IGAD1 immunoglobulin A (IgA) deficiency susceptibility 1
IGF2 insulin-like growth factor 2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL13 interleukin 13
IL17A interleukin 17A
IL1B interleukin 1, beta
IL4 interleukin 4
IL5 interleukin 5
IL6 interleukin 6
INS insulin
LEP leptin
LEPR leptin receptor
LHX3 LIM homeobox 3
MAOA monoamine oxidase A
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPT microtubule-associated protein tau
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MMP9 matrix metallopeptidase 9
NCOR2 nuclear receptor corepressor 2
NPPB natriuretic peptide B
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR3C2 nuclear receptor subfamily 3, group C, member 2
OPRK1 opioid receptor, kappa 1
OPRM1 opioid receptor, mu 1
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
PER2 period circadian clock 2
PER3 period circadian clock 3
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLIN1 perilipin 1
POMC proopiomelanocortin
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PRL prolactin
PROP1 PROP paired-like homeobox 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RHOA ras homolog family member A
S100B S100 calcium binding protein B
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
SGK1 serum/glucocorticoid regulated kinase 1
SHBG sex hormone-binding globulin
SLC38A2 solute carrier family 38, member 2
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SP1 Sp1 transcription factor
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SRD5A3 steroid 5 alpha-reductase 3
STAR steroidogenic acute regulatory protein
STMN1 stathmin 1
TERT telomerase reverse transcriptase
TGFB2 transforming growth factor, beta 2
TNF tumor necrosis factor
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast)
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TSC22D3 TSC22 domain family, member 3
VIPR1 vasoactive intestinal peptide receptor 1
WNT4 wingless-type MMTV integration site family, member 4