A C21-steroid that is pregn-4-ene substituted by oxo groups at positions 3 and 20 and hydroxy groups at positions 11, 17 and 21. Cortisol is a corticosteroid hormone or glucocorticoid produced by zona fasciculata of the adrenal cortex, which is a part of the adrenal gland. It is usually referred to as the stress hormone as it is involved in response to stress and anxiety, controlled by corticotropin-releasing hormone (CRH). It increases blood pressure and blood sugar, and reduces immune responses (Chemical Entities of Biological Interest Ontology, CHEBI_17650)
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11 genes differentially expressed following the cortisol small molecule perturbation from the LINCS L1000 CMAP Chemical Perturbation Consensus Signatures dataset.
