creatine biosynthesis Gene Set

Dataset HumanCyc Pathways
Category structural or functional annotations
Type pathway
Description The chemical reactions and pathways resulting in the formation of creatine, N-[amino(imino)methyl]-N-methylglycine. Creatine is formed by a process beginning with amidino group transfer from L-arginine to glycine to form guanidinoacetate, followed by methyl group transfer from S-adenosyl-L-methionine to guanidinoacetate; it is then is phosphorylated to form a pool that stores high energy phosphate for the replenishment of ATP during periods of high, or fluctuating energy demand. In animals, most creatine is transported to and used in muscle. (Gene Ontology, GO_0006601)
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2 proteins participating in the creatine biosynthesis pathway from the HumanCyc Pathways dataset.

Symbol Name
GAMT guanidinoacetate N-methyltransferase
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)