creb1_22108299_lung_lof_mouse_gpl1261_gds3660 Gene Set

Dataset GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations
Category transcriptomics
Type transcription factor perturbation
Description transcription factor perturbation identified as [TF gene symbol]_[publication PMID]_[cell or tissue]_[perturbation]_[organism]_[GEO platform]_[GEO accession] (Gene Expression Omnibus)
External Link http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GDS3660
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Genes

352 genes differentially expressed following the creb1_22108299_lung_lof_mouse_gpl1261_gds3660 transcription factor perturbation from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.

increased expression

Symbol Name Standardized Value
FMOD fibromodulin 0.21906
PDGFD platelet derived growth factor D 0.218186
SCN7A sodium channel, voltage gated, type VII alpha subunit 0.217219
LHX6 LIM homeobox 6 0.215958
GCC2 GRIP and coiled-coil domain containing 2 0.215834
LAX1 lymphocyte transmembrane adaptor 1 0.215335
NOL9 nucleolar protein 9 0.213057
RAB18 RAB18, member RAS oncogene family 0.208646
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 0.208106
RRM1 ribonucleotide reductase M1 0.207737
ANGPT2 angiopoietin 2 0.207582
MEF2C myocyte enhancer factor 2C 0.206601
EPM2AIP1 EPM2A (laforin) interacting protein 1 0.203019
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 0.197734
SRSF2 serine/arginine-rich splicing factor 2 0.195869
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.194427
IER5 immediate early response 5 0.193508
MAGT1 magnesium transporter 1 0.192872
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.191212
UBE2D2 ubiquitin-conjugating enzyme E2D 2 0.188999
EGR1 early growth response 1 0.186175
ZC3HAV1L zinc finger CCCH-type, antiviral 1-like 0.184359
CXCR3 chemokine (C-X-C motif) receptor 3 0.18317
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein 0.177348
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 0.17494
GPC6 glypican 6 0.174909
FOXC1 forkhead box C1 0.174632
ZNF616 zinc finger protein 616 0.173508
WLS wntless Wnt ligand secretion mediator 0.173057
CCND2 cyclin D2 0.172808
CRLF3 cytokine receptor-like factor 3 0.172575
PCBP2 poly(rC) binding protein 2 0.172373
ESD esterase D 0.171443
PLK2 polo-like kinase 2 0.170994
FOXRED2 FAD-dependent oxidoreductase domain containing 2 0.170438
SP100 SP100 nuclear antigen 0.170407
FKBP6 FK506 binding protein 6, 36kDa 0.166392
ITGA8 integrin, alpha 8 0.16633
CADM1 cell adhesion molecule 1 0.163904
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.160349
PPHLN1 periphilin 1 0.158125
RNF157 ring finger protein 157 0.158093
PLS3 plastin 3 0.156612
KRTAP12-1 keratin associated protein 12-1 0.155748
HLA-DMA major histocompatibility complex, class II, DM alpha 0.153798
MEPCE methylphosphate capping enzyme 0.151939
CYTH1 cytohesin 1 0.149166
BZW1 basic leucine zipper and W2 domains 1 0.141646
NKG7 natural killer cell granule protein 7 0.140008
CYR61 cysteine-rich, angiogenic inducer, 61 0.138355
CD247 CD247 molecule 0.137582
TRIM8 tripartite motif containing 8 0.134909
TXK TXK tyrosine kinase 0.134483
CXXC1 CXXC finger protein 1 0.13302
RPS29 ribosomal protein S29 0.125122
TUBB4A tubulin, beta 4A class IVa 0.121208
CD4 CD4 molecule 0.117821
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.116212
MTSS1L metastasis suppressor 1-like 0.115934
RYBP RING1 and YY1 binding protein 0.111783
ADAM10 ADAM metallopeptidase domain 10 0.111075
STAT4 signal transducer and activator of transcription 4 0.107902
FBXO21 F-box protein 21 0.103133
HABP4 hyaluronan binding protein 4 0.101452
ANAPC5 anaphase promoting complex subunit 5 0.100348
PHEX phosphate regulating endopeptidase homolog, X-linked 0.097728
WDR6 WD repeat domain 6 0.097428
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.095046
IRGM immunity-related GTPase family, M 0.094449
MARCO macrophage receptor with collagenous structure 0.088487
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 0.088252
ARL5B ADP-ribosylation factor-like 5B 0.088031
PLK4 polo-like kinase 4 0.085551
RHOBTB1 Rho-related BTB domain containing 1 0.083901
ADRB3 adrenoceptor beta 3 0.082156
MTMR1 myotubularin related protein 1 0.080736
IFI16 interferon, gamma-inducible protein 16 0.078846
DKK3 dickkopf WNT signaling pathway inhibitor 3 0.077769
BDKRB2 bradykinin receptor B2 0.076236
COL12A1 collagen, type XII, alpha 1 0.076179
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 0.074241
TRAF3IP3 TRAF3 interacting protein 3 0.073616
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like 0.072978
CIRBP cold inducible RNA binding protein 0.070692
ITSN1 intersectin 1 (SH3 domain protein) 0.062668
POM121L12 POM121 transmembrane nucleoporin-like 12 0.061543
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 0.055282
OTUD1 OTU deubiquitinase 1 0.054477
DPP8 dipeptidyl-peptidase 8 0.053884
TMEM64 transmembrane protein 64 0.053558
FAM107B family with sequence similarity 107, member B 0.052848
FZD7 frizzled class receptor 7 0.051551
SOX4 SRY (sex determining region Y)-box 4 0.049909
IL7R interleukin 7 receptor 0.049734
CD5 CD5 molecule 0.048916
N4BP2L2 NEDD4 binding protein 2-like 2 0.042296
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 0.04023
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 0.039441
UBAC2 UBA domain containing 2 0.038991
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.037538
FAM71E1 family with sequence similarity 71, member E1 0.037007
IL17D interleukin 17D 0.035203
PHKA1 phosphorylase kinase, alpha 1 (muscle) 0.034541
FAM114A1 family with sequence similarity 114, member A1 0.03421
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) 0.033219
UGCG UDP-glucose ceramide glucosyltransferase 0.030383
BCL2 B-cell CLL/lymphoma 2 0.028979
MIER1 mesoderm induction early response 1, transcriptional regulator 0.025874
PHKA2 phosphorylase kinase, alpha 2 (liver) 0.024467
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 0.021345
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 0.02041
RND3 Rho family GTPase 3 0.016707
EMCN endomucin 0.016605
POU2AF1 POU class 2 associating factor 1 0.016553
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.015789
PVRL3 poliovirus receptor-related 3 0.014323
HLA-A major histocompatibility complex, class I, A 0.013317
MBTPS1 membrane-bound transcription factor peptidase, site 1 0.011844
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.009787
ODF2 outer dense fiber of sperm tails 2 0.007265
PHF3 PHD finger protein 3 0.005597
STEAP3 STEAP family member 3, metalloreductase 0.003012
C11ORF87 chromosome 11 open reading frame 87 0.002656
API5 apoptosis inhibitor 5 0.001309
EIF4A1 eukaryotic translation initiation factor 4A1 6.28E-4

decreased expression

Symbol Name Standardized Value
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -1.20669
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked -1.20598
SYNJ2BP synaptojanin 2 binding protein -1.20268
ICK intestinal cell (MAK-like) kinase -1.18382
SRR serine racemase -1.18156
LUC7L LUC7-like (S. cerevisiae) -1.18037
TMPRSS2 transmembrane protease, serine 2 -1.1762
TRABD TraB domain containing -1.15703
IP6K2 inositol hexakisphosphate kinase 2 -1.13966
B3GALNT1 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) -1.13055
UBA5 ubiquitin-like modifier activating enzyme 5 -1.12602
VWA3A von Willebrand factor A domain containing 3A -1.12451
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -1.10829
C2CD2 C2 calcium-dependent domain containing 2 -1.10304
NAMPT nicotinamide phosphoribosyltransferase -1.10304
CHKB choline kinase beta -1.09966
RREB1 ras responsive element binding protein 1 -1.09378
MLEC malectin -1.09299
MVD mevalonate (diphospho) decarboxylase -1.08554
ZSWIM6 zinc finger, SWIM-type containing 6 -1.08395
LMNA lamin A/C -1.07375
TSPAN11 tetraspanin 11 -1.05474
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -1.04768
CTSH cathepsin H -1.03835
CRELD2 cysteine-rich with EGF-like domains 2 -1.03656
HPS3 Hermansky-Pudlak syndrome 3 -1.03088
TXN thioredoxin -1.0283
RABEPK Rab9 effector protein with kelch motifs -1.02286
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1 -1.02139
DBNDD2 dysbindin (dystrobrevin binding protein 1) domain containing 2 -1.0079
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide -0.992497
MAT2A methionine adenosyltransferase II, alpha -0.989663
RBM39 RNA binding motif protein 39 -0.978658
CCDC141 coiled-coil domain containing 141 -0.975741
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.960148
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -0.957427
TDGF1 teratocarcinoma-derived growth factor 1 -0.934103
PURG purine-rich element binding protein G -0.928622
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H -0.925585
HAX1 HCLS1 associated protein X-1 -0.923685
ANKRD33B ankyrin repeat domain 33B -0.912211
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila) -0.899331
ARHGEF25 Rho guanine nucleotide exchange factor (GEF) 25 -0.898359
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 -0.893136
DUSP3 dual specificity phosphatase 3 -0.891897
BST1 bone marrow stromal cell antigen 1 -0.89038
STMN2 stathmin 2 -0.886084
RASSF2 Ras association (RalGDS/AF-6) domain family member 2 -0.884132
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -0.863253
TP53 tumor protein p53 -0.862235
ZNF606 zinc finger protein 606 -0.860793
PCBP4 poly(rC) binding protein 4 -0.856372
PIGL phosphatidylinositol glycan anchor biosynthesis, class L -0.855204
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1 -0.84758
HIST1H2BC histone cluster 1, H2bc -0.845759
CENPT centromere protein T -0.83938
KANK3 KN motif and ankyrin repeat domains 3 -0.8242
FAM168A family with sequence similarity 168, member A -0.820264
ABHD5 abhydrolase domain containing 5 -0.816791
MAP3K8 mitogen-activated protein kinase kinase kinase 8 -0.811291
BRD8 bromodomain containing 8 -0.80609
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 -0.805219
CCDC120 coiled-coil domain containing 120 -0.802137
RNF141 ring finger protein 141 -0.794945
ANKRD16 ankyrin repeat domain 16 -0.755664
KLHL5 kelch-like family member 5 -0.751286
TMEM14C transmembrane protein 14C -0.74695
CCNL1 cyclin L1 -0.743419
STRAP serine/threonine kinase receptor associated protein -0.739622
TDRD3 tudor domain containing 3 -0.738489
IGHM immunoglobulin heavy constant mu -0.736566
NEURL4 neuralized E3 ubiquitin protein ligase 4 -0.736107
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 -0.734485
HIST1H1C histone cluster 1, H1c -0.722168
TMEM132A transmembrane protein 132A -0.721362
KCTD18 potassium channel tetramerization domain containing 18 -0.716362
MALAT1 metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) -0.716004
USP32 ubiquitin specific peptidase 32 -0.714616
WDR12 WD repeat domain 12 -0.71264
STX5 syntaxin 5 -0.701792
RBM33 RNA binding motif protein 33 -0.698508
STK19 serine/threonine kinase 19 -0.69213
B3GNT7 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 -0.68571
ANKRD54 ankyrin repeat domain 54 -0.682813
NPC2 Niemann-Pick disease, type C2 -0.68121
USP8 ubiquitin specific peptidase 8 -0.677086
SNHG7 small nucleolar RNA host gene 7 -0.672546
HIST1H2BH histone cluster 1, H2bh -0.66488
HIST1H4D histone cluster 1, H4d -0.663596
EMC7 ER membrane protein complex subunit 7 -0.646222
PTOV1 prostate tumor overexpressed 1 -0.644849
NOP16 NOP16 nucleolar protein -0.643408
GAS2L1 growth arrest-specific 2 like 1 -0.641398
CNOT3 CCR4-NOT transcription complex, subunit 3 -0.638842
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2 -0.628171
MFAP5 microfibrillar associated protein 5 -0.628103
KLC4 kinesin light chain 4 -0.627896
MTG2 mitochondrial ribosome-associated GTPase 2 -0.623604
FAM114A2 family with sequence similarity 114, member A2 -0.617833
EIF5B eukaryotic translation initiation factor 5B -0.61217
CCDC71L coiled-coil domain containing 71-like -0.60027
CCR1 chemokine (C-C motif) receptor 1 -0.599578
FOXN2 forkhead box N2 -0.593321
RBPMS RNA binding protein with multiple splicing -0.588877
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2 -0.5854
B3GAT3 beta-1,3-glucuronyltransferase 3 -0.572861
SETD8 SET domain containing (lysine methyltransferase) 8 -0.572407
C4B complement component 4B (Chido blood group) -0.571437
KLHDC4 kelch domain containing 4 -0.569627
NUCB2 nucleobindin 2 -0.564385
AP2A2 adaptor-related protein complex 2, alpha 2 subunit -0.558707
NAP1L1 nucleosome assembly protein 1-like 1 -0.552094
MTMR3 myotubularin related protein 3 -0.549069
RAB4A RAB4A, member RAS oncogene family -0.543622
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -0.538398
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like -0.537953
EPS8L1 EPS8-like 1 -0.536815
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B -0.535383
DPP4 dipeptidyl-peptidase 4 -0.534746
DEDD2 death effector domain containing 2 -0.533921
NOL8 nucleolar protein 8 -0.531211
EGR2 early growth response 2 -0.530296
MAP3K10 mitogen-activated protein kinase kinase kinase 10 -0.525937
VNN1 vanin 1 -0.525795
RNMT RNA (guanine-7-) methyltransferase -0.523505
ST7L suppression of tumorigenicity 7 like -0.523322
NFYB nuclear transcription factor Y, beta -0.522766
TCEANC2 transcription elongation factor A (SII) N-terminal and central domain containing 2 -0.519047
RGS7BP regulator of G-protein signaling 7 binding protein -0.513714
RAB12 RAB12, member RAS oncogene family -0.503678
KCNQ1OT1 KCNQ1 opposite strand/antisense transcript 1 (non-protein coding) -0.49973
COL7A1 collagen, type VII, alpha 1 -0.495921
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 -0.495116
SC5D sterol-C5-desaturase -0.492586
TWF1 twinfilin actin binding protein 1 -0.49117
PIKFYVE phosphoinositide kinase, FYVE finger containing -0.490392
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) -0.490238
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.484044
PGD phosphogluconate dehydrogenase -0.476629
STC2 stanniocalcin 2 -0.476417
TMEM219 transmembrane protein 219 -0.475146
TRIM39 tripartite motif containing 39 -0.474442
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K -0.473888
UBE2A ubiquitin-conjugating enzyme E2A -0.473681
RAB6A RAB6A, member RAS oncogene family -0.472168
TMEM230 transmembrane protein 230 -0.467022
THOC1 THO complex 1 -0.466855
ASB13 ankyrin repeat and SOCS box containing 13 -0.465555
CCDC22 coiled-coil domain containing 22 -0.46355
ACBD6 acyl-CoA binding domain containing 6 -0.45806
CPNE9 copine family member IX -0.457391
IGFBP6 insulin-like growth factor binding protein 6 -0.456177
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial -0.454613
EGFL7 EGF-like-domain, multiple 7 -0.451733
KIFC2 kinesin family member C2 -0.448492
GSK3B glycogen synthase kinase 3 beta -0.446083
SPHK1 sphingosine kinase 1 -0.443008
DIAPH1 diaphanous-related formin 1 -0.441873
NXF1 nuclear RNA export factor 1 -0.441694
CCT3 chaperonin containing TCP1, subunit 3 (gamma) -0.438849
UBE3C ubiquitin protein ligase E3C -0.436779
EIF3A eukaryotic translation initiation factor 3, subunit A -0.436059
LAT2 linker for activation of T cells family, member 2 -0.431878
RCAN2 regulator of calcineurin 2 -0.430854
SLC22A15 solute carrier family 22, member 15 -0.43041
UBE3A ubiquitin protein ligase E3A -0.430125
ERCC5 excision repair cross-complementation group 5 -0.427984
KLF10 Kruppel-like factor 10 -0.426556
GPKOW G patch domain and KOW motifs -0.424065
ZC3H7A zinc finger CCCH-type containing 7A -0.422197
SCN3B sodium channel, voltage gated, type III beta subunit -0.061575
LIN7C lin-7 homolog C (C. elegans) -0.060412
FRS2 fibroblast growth factor receptor substrate 2 -0.059445
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3 -0.058544
ARF4 ADP-ribosylation factor 4 -0.058357
ZNF106 zinc finger protein 106 -0.0583
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.056535
DDX19A DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A -0.055387
GLE1 GLE1 RNA export mediator -0.055174
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.053646
CD3G CD3g molecule, gamma (CD3-TCR complex) -0.05347
HUS1 HUS1 checkpoint homolog (S. pombe) -0.052056
MEIS2 Meis homeobox 2 -0.05127
SRCAP Snf2-related CREBBP activator protein -0.04508
BROX BRO1 domain and CAAX motif containing -0.043658
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme -0.04246
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.041915
TMEM38A transmembrane protein 38A -0.040849
GEM GTP binding protein overexpressed in skeletal muscle -0.039716
UBE2I ubiquitin-conjugating enzyme E2I -0.039673
DPY19L3 dpy-19-like 3 (C. elegans) -0.038173
LIPA lipase A, lysosomal acid, cholesterol esterase -0.037558
NUDT16L1 nudix (nucleoside diphosphate linked moiety X)-type motif 16-like 1 -0.036127
LIMS1 LIM and senescent cell antigen-like domains 1 -0.034409
PRSS23 protease, serine, 23 -0.030876
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2 -0.030352
LRRC17 leucine rich repeat containing 17 -0.029979
SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa -0.029781
ARCN1 archain 1 -0.029101
ZDHHC17 zinc finger, DHHC-type containing 17 -0.028444
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.027605
USP24 ubiquitin specific peptidase 24 -0.027516
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B -0.026853
CLNS1A chloride channel, nucleotide-sensitive, 1A -0.026366
IDUA iduronidase, alpha-L- -0.02619
COL4A6 collagen, type IV, alpha 6 -0.024455
IKZF1 IKAROS family zinc finger 1 (Ikaros) -0.02372
BLMH bleomycin hydrolase -0.022332
FMR1 fragile X mental retardation 1 -0.020808
EDN3 endothelin 3 -0.019565
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.01678
PEX11B peroxisomal biogenesis factor 11 beta -0.016462
IL12A interleukin 12A -0.016235
GBP3 guanylate binding protein 3 -0.0161
SDF4 stromal cell derived factor 4 -0.012833
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) -0.012764
MFSD4 major facilitator superfamily domain containing 4 -0.012718
CTSW cathepsin W -0.009523
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.009153
ARHGAP29 Rho GTPase activating protein 29 -0.008348
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme -0.007653
LTBP3 latent transforming growth factor beta binding protein 3 -0.006473
GHR growth hormone receptor -0.005314
RBBP4 retinoblastoma binding protein 4 -0.002875
TCF3 transcription factor 3 -0.002127
CDC42 cell division cycle 42 -0.001265
KIDINS220 kinase D-interacting substrate, 220kDa -8.46E-4