cAMP responsive element modulator|This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1390)
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12 genes co-occuring with the biological term crem in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
