crizotinib_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description crizotinib perturbation in A-172 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the crizotinib_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.115635
SLC39A11 solute carrier family 39, member 11 0.0622178
AUTS2 autism susceptibility candidate 2 0.0576236
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0556293
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.053454
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0477042
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0458374
DLG1 discs, large homolog 1 (Drosophila) 0.0436054
FNIP1 folliculin interacting protein 1 0.0399405
GPC6 glypican 6 0.0367248
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0356582
CD109 CD109 molecule 0.0347836
GOLGA4 golgin A4 0.0318089
CDH13 cadherin 13 0.0312489
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0304488
NAV2 neuron navigator 2 0.030021
SBF2 SET binding factor 2 0.0275564
ATP13A3 ATPase type 13A3 0.0267851
ZEB1 zinc finger E-box binding homeobox 1 0.0260132
SPIRE1 spire-type actin nucleation factor 1 0.025571
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0250537
ANKRD11 ankyrin repeat domain 11 0.0249581
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0242643
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.02395
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0235249
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0232635
HELZ helicase with zinc finger 0.0230881
FMNL2 formin-like 2 0.0228655
ZNF292 zinc finger protein 292 0.0225732
ARHGAP12 Rho GTPase activating protein 12 0.0225605
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0224729
FBXL7 F-box and leucine-rich repeat protein 7 0.0223998
HDAC9 histone deacetylase 9 0.0218341
CYLD cylindromatosis (turban tumor syndrome) 0.0216789
KDM6A lysine (K)-specific demethylase 6A 0.0214811
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0214304
ANKRD10 ankyrin repeat domain 10 0.0213782
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0213345
VEGFA vascular endothelial growth factor A 0.0206827
MSI2 musashi RNA-binding protein 2 0.0205683
FSD1L fibronectin type III and SPRY domain containing 1-like 0.0205377
AFDN afadin, adherens junction formation factor 0.0200998
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0199596
JAZF1 JAZF zinc finger 1 0.0199583
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0199028
BACE2 beta-site APP-cleaving enzyme 2 0.0197903
KMT2C lysine (K)-specific methyltransferase 2C 0.0197605
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0197577
RB1CC1 RB1-inducible coiled-coil 1 0.0194394
ZBTB7C zinc finger and BTB domain containing 7C 0.0193078
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0192097
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0191385
NBAS neuroblastoma amplified sequence 0.01907
PBX3 pre-B-cell leukemia homeobox 3 0.0189141
WDFY3 WD repeat and FYVE domain containing 3 0.0188973
DST dystonin 0.0187621
ADAM17 ADAM metallopeptidase domain 17 0.0186462
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.0186127
SSBP2 single-stranded DNA binding protein 2 0.0185538
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0179933
SQSTM1 sequestosome 1 0.0179513
AHNAK2 AHNAK nucleoprotein 2 0.0175762
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0175357
DENND1A DENN/MADD domain containing 1A 0.0174687
MSN moesin 0.0172027
COPA coatomer protein complex, subunit alpha 0.0170056
LCOR ligand dependent nuclear receptor corepressor 0.0165249
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 0.0164593
TTC3 tetratricopeptide repeat domain 3 0.0164369
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0163199
AFF3 AF4/FMR2 family, member 3 0.0161905
GOLGB1 golgin B1 0.0161467
NEK7 NIMA-related kinase 7 0.015594
GLS2 glutaminase 2 (liver, mitochondrial) 0.0155287
OGA O-GlcNAcase 0.0153759
MEF2A myocyte enhancer factor 2A 0.0153676
CCNY cyclin Y 0.0153513
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.015234
GRB10 growth factor receptor-bound protein 10 0.0152182
RICTOR RPTOR independent companion of MTOR, complex 2 0.0151604
PUM2 pumilio RNA-binding family member 2 0.0150637
LINGO2 leucine rich repeat and Ig domain containing 2 0.0149466
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.01475
DCAF6 DDB1 and CUL4 associated factor 6 0.0146304
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0146219
TOX thymocyte selection-associated high mobility group box 0.0146201
ZFAND3 zinc finger, AN1-type domain 3 0.0146179
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.0144738
SUCO SUN domain containing ossification factor 0.0143731
DSCAM Down syndrome cell adhesion molecule 0.0143484
EGFR epidermal growth factor receptor 0.0142814
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 0.0142602
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0141761
RAB18 RAB18, member RAS oncogene family 0.0141594
TENT4A terminal nucleotidyltransferase 4A 0.0141193
PALS2 protein associated with LIN7 2, MAGUK p55 family member 0.0138732
CEP170 centrosomal protein 170kDa 0.0137293
ARHGAP21 Rho GTPase activating protein 21 0.0136154
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0136083
ARL8B ADP-ribosylation factor-like 8B 0.0135874

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.273466
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.267599
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.219026
TMSB10 thymosin beta 10 -0.210086
MT2A metallothionein 2A -0.172021
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.14756
UBC ubiquitin C -0.145069
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.141275
PTMA prothymosin, alpha -0.102838
LOX lysyl oxidase -0.0988418
AHNAK AHNAK nucleoprotein -0.0859706
CD44 CD44 molecule (Indian blood group) -0.0848442
COL3A1 collagen, type III, alpha 1 -0.0821482
FBN1 fibrillin 1 -0.0818595
S100A10 S100 calcium binding protein A10 -0.0789637
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0787128
S100A6 S100 calcium binding protein A6 -0.0729394
HLA-B major histocompatibility complex, class I, B -0.0688329
POTEF POTE ankyrin domain family, member F -0.0645536
COL1A2 collagen, type I, alpha 2 -0.059266
CALR calreticulin -0.0578969
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0570229
LOC112694756 uncharaterized LOC112694756 -0.0559131
IFITM3 interferon induced transmembrane protein 3 -0.0519473
ANXA2 annexin A2 -0.0516065
IFITM1 interferon induced transmembrane protein 1 -0.0491492
MX2 MX dynamin-like GTPase 2 -0.0490054
SAMD9 sterile alpha motif domain containing 9 -0.0478029
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0475087
TAGLN2 transgelin 2 -0.0474147
PDIA3 protein disulfide isomerase family A, member 3 -0.046389
COL5A2 collagen, type V, alpha 2 -0.0455103
STC1 stanniocalcin 1 -0.0448773
MAP1B microtubule-associated protein 1B -0.0441112
HLA-C major histocompatibility complex, class I, C -0.0430393
NAV1 neuron navigator 1 -0.0424064
LDHA lactate dehydrogenase A -0.0421267
PODXL podocalyxin-like -0.0414872
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0409137
IFI16 interferon, gamma-inducible protein 16 -0.0408862
CANX calnexin -0.0407997
RPL23 ribosomal protein L23 -0.0397134
SLC38A1 solute carrier family 38, member 1 -0.0391016
COL5A1 collagen, type V, alpha 1 -0.0387619
RPS27A ribosomal protein S27a -0.0383714
HLA-E major histocompatibility complex, class I, E -0.0382303
TPT1 tumor protein, translationally-controlled 1 -0.037962
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0375753
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0371486
CSTB cystatin B (stefin B) -0.0369787
MT1X metallothionein 1X -0.0369184
PKM pyruvate kinase, muscle -0.0364516
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0349646
RNF213 ring finger protein 213 -0.0333056
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0332974
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0332104
PRSS23 protease, serine, 23 -0.0328814
FTL ferritin, light polypeptide -0.0327278
CD99 CD99 molecule -0.0322677
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0322422
ENO1 enolase 1, (alpha) -0.0310735
RPLP1 ribosomal protein, large, P1 -0.0310196
TXNIP thioredoxin interacting protein -0.0306725
RPL28 ribosomal protein L28 -0.0302661
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0294668
GNAS GNAS complex locus -0.0289137
CDK6 cyclin-dependent kinase 6 -0.0287143
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0285759
VDAC1 voltage-dependent anion channel 1 -0.0282601
PLAT plasminogen activator, tissue -0.0281164
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0279791
COL8A1 collagen, type VIII, alpha 1 -0.0279299
IFI6 interferon, alpha-inducible protein 6 -0.0278037
JUN jun proto-oncogene -0.0272871
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0269594
IFIH1 interferon induced with helicase C domain 1 -0.0268031
TM4SF1 transmembrane 4 L six family member 1 -0.0265017
CAVIN1 caveolae associated protein 1 -0.0258563
DKK3 dickkopf WNT signaling pathway inhibitor 3 -0.0256956
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0253507
PDIA4 protein disulfide isomerase family A, member 4 -0.0249838
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0245585
RPS24 ribosomal protein S24 -0.0242011
LMNA lamin A/C -0.0238694
AKAP12 A kinase (PRKA) anchor protein 12 -0.0236631
CTSB cathepsin B -0.0233309
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0233259
EIF1 eukaryotic translation initiation factor 1 -0.0231946
PRRC2C proline-rich coiled-coil 2C -0.0230099
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa -0.0226386
MYL12B myosin, light chain 12B, regulatory -0.0221307
H3-3B H3.3 histone B -0.0220664
IER3 immediate early response 3 -0.0220602
CKAP4 cytoskeleton-associated protein 4 -0.0220011
NAP1L1 nucleosome assembly protein 1-like 1 -0.0219671
SP100 SP100 nuclear antigen -0.0218249
RPL35A ribosomal protein L35a -0.0218159
S100A11 S100 calcium binding protein A11 -0.0217505
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.0216753
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0215881