| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | crizotinib perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the crizotinib_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.0387616 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0383607 |
| CCNL1 | cyclin L1 | 0.0382403 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0367383 |
| TXNRD1 | thioredoxin reductase 1 | 0.0349833 |
| NEK7 | NIMA-related kinase 7 | 0.0340407 |
| MED13L | mediator complex subunit 13-like | 0.0332071 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0291401 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0277891 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.026606 |
| MGAT4C | MGAT4 family, member C | 0.0265488 |
| OGA | O-GlcNAcase | 0.0249283 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0248148 |
| RBM39 | RNA binding motif protein 39 | 0.0242891 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0233152 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.0230295 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0223766 |
| QKI | QKI, KH domain containing, RNA binding | 0.0219246 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.0216124 |
| CPOX | coproporphyrinogen oxidase | 0.0212127 |
| RYK | receptor-like tyrosine kinase | 0.0208443 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0205582 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | 0.0204524 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0203737 |
| ZNF292 | zinc finger protein 292 | 0.0198948 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0197196 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0192772 |
| TFG | TRK-fused gene | 0.0191831 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0190911 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0188873 |
| ECT2 | epithelial cell transforming 2 | 0.0187072 |
| THOC1 | THO complex 1 | 0.0185219 |
| CDK17 | cyclin-dependent kinase 17 | 0.0182657 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0175529 |
| LMO7 | LIM domain 7 | 0.0174578 |
| WDR43 | WD repeat domain 43 | 0.0173785 |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | 0.0173056 |
| PER1 | period circadian clock 1 | 0.0169433 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0169267 |
| MEMO1 | mediator of cell motility 1 | 0.0169187 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0168544 |
| CEP95 | centrosomal protein 95kDa | 0.0168354 |
| KLHL24 | kelch-like family member 24 | 0.0165699 |
| ATL2 | atlastin GTPase 2 | 0.0165641 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0160984 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0160669 |
| NCKAP1 | NCK-associated protein 1 | 0.0160207 |
| GASK1B | golgi associated kinase 1B | 0.0156943 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.0156839 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0152212 |
| YTHDC1 | YTH domain containing 1 | 0.0149439 |
| CASC3 | cancer susceptibility candidate 3 | 0.0148501 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | 0.0147138 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0146002 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0145782 |
| ORC4 | origin recognition complex, subunit 4 | 0.014302 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0142625 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 0.0141366 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0138899 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0138783 |
| CEP192 | centrosomal protein 192kDa | 0.0137208 |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 | 0.0136744 |
| PPP4R1 | protein phosphatase 4, regulatory subunit 1 | 0.0133927 |
| CDC73 | cell division cycle 73 | 0.0133608 |
| RBM33 | RNA binding motif protein 33 | 0.0132633 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0131352 |
| RNF145 | ring finger protein 145 | 0.01313 |
| CDK19 | cyclin-dependent kinase 19 | 0.0131076 |
| TNRC6A | trinucleotide repeat containing 6A | 0.0130409 |
| USP3 | ubiquitin specific peptidase 3 | 0.0130088 |
| ARID4A | AT rich interactive domain 4A (RBP1-like) | 0.0128801 |
| AFDN | afadin, adherens junction formation factor | 0.0128526 |
| SUCO | SUN domain containing ossification factor | 0.0128259 |
| ABI1 | abl-interactor 1 | 0.0126524 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0126475 |
| CXADR | coxsackie virus and adenovirus receptor | 0.0126116 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0126019 |
| PHF3 | PHD finger protein 3 | 0.0125718 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0125387 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0125011 |
| ELP2 | elongator acetyltransferase complex subunit 2 | 0.0124941 |
| HBP1 | HMG-box transcription factor 1 | 0.0124294 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0123685 |
| SQSTM1 | sequestosome 1 | 0.0123532 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0123469 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0122947 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0122447 |
| KPNA1 | karyopherin alpha 1 (importin alpha 5) | 0.0121977 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | 0.0121495 |
| RLF | rearranged L-myc fusion | 0.0121455 |
| USP15 | ubiquitin specific peptidase 15 | 0.0120876 |
| PNN | pinin, desmosome associated protein | 0.0115752 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0115494 |
| RASA2 | RAS p21 protein activator 2 | 0.0115383 |
| ZFAND6 | zinc finger, AN1-type domain 6 | 0.0115301 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0115185 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0114997 |
| LEMD3 | LEM domain containing 3 | 0.0114361 |
| ETNK1 | ethanolamine kinase 1 | 0.0114249 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0114152 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.295483 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.277953 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.221152 |
| NLGN1 | neuroligin 1 | -0.183766 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.150322 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.115935 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.113239 |
| AREG | amphiregulin | -0.100345 |
| ACTG1 | actin gamma 1 | -0.0929463 |
| MMP12 | matrix metallopeptidase 12 | -0.0925615 |
| DST | dystonin | -0.0862747 |
| HMGA2 | high mobility group AT-hook 2 | -0.0818762 |
| TMSB10 | thymosin beta 10 | -0.0786097 |
| PCDH7 | protocadherin 7 | -0.0725165 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0722808 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0718075 |
| TPI1 | triosephosphate isomerase 1 | -0.0663205 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0611558 |
| EHBP1 | EH domain binding protein 1 | -0.061144 |
| PTMA | prothymosin, alpha | -0.0581332 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0562547 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0560699 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0560549 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0559678 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0558791 |
| EGR1 | early growth response 1 | -0.0554071 |
| TUBA1B | tubulin, alpha 1b | -0.0548759 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0529609 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0506284 |
| RASAL2 | RAS protein activator like 2 | -0.0489483 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0465621 |
| POTEF | POTE ankyrin domain family, member F | -0.0459618 |
| HMGA1 | high mobility group AT-hook 1 | -0.0451643 |
| LDHA | lactate dehydrogenase A | -0.0443339 |
| ANXA1 | annexin A1 | -0.0436268 |
| PFN1 | profilin 1 | -0.0431264 |
| MAP1B | microtubule-associated protein 1B | -0.0430085 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0416943 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0412774 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0395383 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0394144 |
| CCN2 | cellular communication network factor 2 | -0.0386822 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0377843 |
| TENM3 | teneurin transmembrane protein 3 | -0.0364178 |
| CCND1 | cyclin D1 | -0.0359979 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0355554 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0355024 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0353723 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0347685 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0346878 |
| TMEM123 | transmembrane protein 123 | -0.0346363 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0346315 |
| CANX | calnexin | -0.0339458 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | -0.0334053 |
| ENO1 | enolase 1, (alpha) | -0.0331102 |
| MKI67 | marker of proliferation Ki-67 | -0.0329551 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0328575 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0328554 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0327796 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0327033 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0326248 |
| NEBL | nebulette | -0.0322496 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0316614 |
| MTAP | methylthioadenosine phosphorylase | -0.030983 |
| PRDX1 | peroxiredoxin 1 | -0.0308967 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0307609 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0303659 |
| RPS6 | ribosomal protein S6 | -0.0300996 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0299136 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0298799 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0297939 |
| LDHB | lactate dehydrogenase B | -0.0293585 |
| RPS8 | ribosomal protein S8 | -0.0285685 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0283871 |
| RPL12 | ribosomal protein L12 | -0.0282699 |
| BPTF | bromodomain PHD finger transcription factor | -0.0281518 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | -0.028013 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0279873 |
| ADIPOR2 | adiponectin receptor 2 | -0.0276348 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0276322 |
| CLDN1 | claudin 1 | -0.0275978 |
| IPO7 | importin 7 | -0.0273774 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0273247 |
| TGM2 | transglutaminase 2 | -0.0269663 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.026788 |
| PTMS | parathymosin | -0.0267488 |
| TPM3 | tropomyosin 3 | -0.0265437 |
| RPLP0 | ribosomal protein, large, P0 | -0.0264156 |
| EXOC4 | exocyst complex component 4 | -0.0263344 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0259442 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0256298 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.025549 |
| SPATS2 | spermatogenesis associated, serine-rich 2 | -0.0249516 |
| RACK1 | receptor for activated C kinase 1 | -0.0247455 |
| RPL23 | ribosomal protein L23 | -0.024638 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | -0.0245105 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0244891 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0243858 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0242387 |
| TUBB | tubulin, beta class I | -0.0241863 |
