| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | crizotinib perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the crizotinib_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.20117 |
| ATP13A3 | ATPase type 13A3 | 0.164628 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.132159 |
| VIM | vimentin | 0.127855 |
| CADM1 | cell adhesion molecule 1 | 0.124414 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.113001 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.112162 |
| TMSB4X | thymosin beta 4, X-linked | 0.0855761 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.084894 |
| PTK2 | protein tyrosine kinase 2 | 0.0842112 |
| B2M | beta-2-microglobulin | 0.0768874 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0754043 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0742977 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0716211 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0714496 |
| RASA2 | RAS p21 protein activator 2 | 0.0713044 |
| ZNF292 | zinc finger protein 292 | 0.0708704 |
| TFG | TRK-fused gene | 0.0691025 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.062777 |
| SPAG9 | sperm associated antigen 9 | 0.0619911 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0593032 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.059229 |
| RLF | rearranged L-myc fusion | 0.0527556 |
| GOLGA4 | golgin A4 | 0.0524747 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0519963 |
| SMAD3 | SMAD family member 3 | 0.050935 |
| RNF145 | ring finger protein 145 | 0.0502237 |
| ARRDC3 | arrestin domain containing 3 | 0.0500602 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0496364 |
| VEGFA | vascular endothelial growth factor A | 0.047945 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0479306 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0478561 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0476497 |
| USP3 | ubiquitin specific peptidase 3 | 0.047531 |
| FMNL2 | formin-like 2 | 0.046477 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0458469 |
| TPM4 | tropomyosin 4 | 0.0450648 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.044646 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0444983 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0443903 |
| DSTN | destrin (actin depolymerizing factor) | 0.0438196 |
| ZNF148 | zinc finger protein 148 | 0.0419699 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0415775 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0414412 |
| ENO1 | enolase 1, (alpha) | 0.0408669 |
| POSTN | periostin, osteoblast specific factor | 0.0408486 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0406767 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.040277 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.03961 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0393509 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0392676 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0391281 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0390188 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0388792 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0387483 |
| LDHA | lactate dehydrogenase A | 0.0387344 |
| SQLE | squalene epoxidase | 0.0384323 |
| RPS6 | ribosomal protein S6 | 0.0380388 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.0379558 |
| MATR3 | matrin 3 | 0.0376029 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0374164 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0373373 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0373083 |
| FOXJ3 | forkhead box J3 | 0.037248 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0372071 |
| QKI | QKI, KH domain containing, RNA binding | 0.0369091 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.0364576 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0359276 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0353331 |
| COL1A2 | collagen, type I, alpha 2 | 0.0342966 |
| MRTFA | myocardin related transcription factor A | 0.0340318 |
| SBF2 | SET binding factor 2 | 0.0340316 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0337111 |
| SKIC3 | SKI3 subunit of superkiller complex | 0.0337109 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0337055 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0333617 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0329705 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0328213 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0324117 |
| YBX1 | Y box binding protein 1 | 0.0323452 |
| FCHSD2 | FCH and double SH3 domains 2 | 0.0319591 |
| COPA | coatomer protein complex, subunit alpha | 0.0319531 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.0317256 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | 0.0316042 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0314718 |
| SNX9 | sorting nexin 9 | 0.0313457 |
| TRAM1 | translocation associated membrane protein 1 | 0.0312605 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0310165 |
| ANXA5 | annexin A5 | 0.0308879 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0308402 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0308177 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0307167 |
| APP | amyloid beta (A4) precursor protein | 0.0306227 |
| PDE8A | phosphodiesterase 8A | 0.0303639 |
| RIPK2 | receptor-interacting serine-threonine kinase 2 | 0.0301642 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0299593 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0299536 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | 0.0298899 |
| RPS2 | ribosomal protein S2 | 0.0297826 |
| RPL3 | ribosomal protein L3 | 0.0294237 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.183232 |
| NDRG1 | N-myc downstream regulated 1 | -0.158902 |
| MT2A | metallothionein 2A | -0.151586 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.13061 |
| FN1 | fibronectin 1 | -0.112779 |
| COL5A1 | collagen, type V, alpha 1 | -0.112311 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0927328 |
| CDH13 | cadherin 13 | -0.075399 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0702723 |
| FBN1 | fibrillin 1 | -0.069067 |
| EXT1 | exostosin glycosyltransferase 1 | -0.062928 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0587026 |
| TMSB10 | thymosin beta 10 | -0.0567163 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0498163 |
| AHNAK | AHNAK nucleoprotein | -0.049616 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.049517 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0419202 |
| COL1A1 | collagen, type I, alpha 1 | -0.040674 |
| GLIS3 | GLIS family zinc finger 3 | -0.0405568 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0396362 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0384239 |
| EGR1 | early growth response 1 | -0.0378969 |
| SQSTM1 | sequestosome 1 | -0.0376115 |
| VCL | vinculin | -0.0364838 |
| PRELID2 | PRELI domain containing 2 | -0.0356895 |
| HDAC9 | histone deacetylase 9 | -0.0346451 |
| NABP1 | nucleic acid binding protein 1 | -0.0342235 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0340881 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0336544 |
| ASPH | aspartate beta-hydroxylase | -0.0331576 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0330252 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0319675 |
| EPHB1 | EPH receptor B1 | -0.0318979 |
| ATXN1 | ataxin 1 | -0.03159 |
| CNTN5 | contactin 5 | -0.0314401 |
| RIGI | RNA sensor RIG-I | -0.0310124 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0308524 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.03066 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0305262 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0295385 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0293418 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.029212 |
| IER3 | immediate early response 3 | -0.0289255 |
| NAV1 | neuron navigator 1 | -0.0285423 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0283333 |
| EXOC4 | exocyst complex component 4 | -0.0274029 |
| EGFR | epidermal growth factor receptor | -0.0273807 |
| RUNX1 | runt-related transcription factor 1 | -0.0270227 |
| INTS6 | integrator complex subunit 6 | -0.0269924 |
| ACTG1 | actin gamma 1 | -0.0265923 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0262254 |
| FTL | ferritin, light polypeptide | -0.0259521 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.0258907 |
| DGKI | diacylglycerol kinase, iota | -0.0255615 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0254597 |
| LOXL2 | lysyl oxidase-like 2 | -0.0254233 |
| MT1X | metallothionein 1X | -0.0253383 |
| COL7A1 | collagen, type VII, alpha 1 | -0.0252698 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0251052 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0248278 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0246313 |
| FOXP1 | forkhead box P1 | -0.0241733 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.024095 |
| CAVIN1 | caveolae associated protein 1 | -0.0235797 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0234214 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0233262 |
| KCTD16 | potassium channel tetramerization domain containing 16 | -0.0230983 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0228888 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0227258 |
| SMYD3 | SET and MYND domain containing 3 | -0.0225838 |
| HLA-B | major histocompatibility complex, class I, B | -0.022468 |
| RRBP1 | ribosome binding protein 1 | -0.0222632 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.0217113 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.0214805 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0212556 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0210642 |
| SETBP1 | SET binding protein 1 | -0.0207081 |
| RPL36 | ribosomal protein L36 | -0.0202211 |
| RPL35A | ribosomal protein L35a | -0.0200973 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0197549 |
| RPLP1 | ribosomal protein, large, P1 | -0.0196295 |
| LOX | lysyl oxidase | -0.0195072 |
| GPC6 | glypican 6 | -0.0193352 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0191711 |
| RPL28 | ribosomal protein L28 | -0.0191594 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.018943 |
| SEC22A | SEC22 vesicle trafficking protein homolog A (S. cerevisiae) | -0.0188823 |
| RPS19 | ribosomal protein S19 | -0.0188819 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0184232 |
| MYO1E | myosin IE | -0.0183866 |
| NCKAP5 | NCK-associated protein 5 | -0.0183463 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0181538 |
| PRSS23 | protease, serine, 23 | -0.018016 |
| H1-0 | H1.0 linker histone | -0.0179192 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0178926 |
| GANAB | glucosidase, alpha; neutral AB | -0.0178481 |
| GLIPR1 | GLI pathogenesis-related 1 | -0.0177456 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0176561 |
| FKBP10 | FK506 binding protein 10, 65 kDa | -0.0174113 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0173844 |
