| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | crizotinib perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the crizotinib_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.148864 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0981943 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0674664 |
| PCBP2 | poly(rC) binding protein 2 | 0.0628968 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0606289 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0552569 |
| SDC4 | syndecan 4 | 0.0547781 |
| AFDN | afadin, adherens junction formation factor | 0.0528753 |
| JMJD1C | jumonji domain containing 1C | 0.0528685 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0526353 |
| VEGFA | vascular endothelial growth factor A | 0.0513276 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0511149 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0504104 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.049485 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0484171 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.048099 |
| QKI | QKI, KH domain containing, RNA binding | 0.0480907 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0480453 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0480436 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | 0.0476495 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0470359 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0460385 |
| MYO6 | myosin VI | 0.0459321 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0455414 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0454319 |
| DTNA | dystrobrevin, alpha | 0.0443271 |
| B2M | beta-2-microglobulin | 0.044281 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0440916 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0432023 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0424934 |
| CCNY | cyclin Y | 0.0424546 |
| SBF2 | SET binding factor 2 | 0.0423888 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0419417 |
| INSIG2 | insulin induced gene 2 | 0.0418825 |
| TMEM123 | transmembrane protein 123 | 0.0417158 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0416085 |
| CANX | calnexin | 0.0410797 |
| HELZ | helicase with zinc finger | 0.0409454 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0407598 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0404463 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0400824 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.039265 |
| ANKRD12 | ankyrin repeat domain 12 | 0.038914 |
| RPL14 | ribosomal protein L14 | 0.0382338 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0380975 |
| PTK2 | protein tyrosine kinase 2 | 0.0380268 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0373303 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0373041 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0372655 |
| SUCO | SUN domain containing ossification factor | 0.0370855 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0369737 |
| GOLGA4 | golgin A4 | 0.0369304 |
| PLIN2 | perilipin 2 | 0.0361934 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.036068 |
| RLF | rearranged L-myc fusion | 0.0359407 |
| RBM39 | RNA binding motif protein 39 | 0.0356942 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0356459 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0356375 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.03553 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0352308 |
| IL6ST | interleukin 6 signal transducer | 0.0351575 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0350026 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0347541 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0346996 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0346869 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0344793 |
| KIF1B | kinesin family member 1B | 0.0340853 |
| DSPP | dentin sialophosphoprotein | 0.033551 |
| PHF21A | PHD finger protein 21A | 0.0334834 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0334242 |
| PAPOLA | poly(A) polymerase alpha | 0.0333834 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0328237 |
| RPL3 | ribosomal protein L3 | 0.0327766 |
| RPL5 | ribosomal protein L5 | 0.0327239 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0324151 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0323714 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0323015 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0319699 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0318887 |
| ZNF451 | zinc finger protein 451 | 0.0315316 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0315252 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | 0.0311869 |
| USP47 | ubiquitin specific peptidase 47 | 0.0311282 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.030846 |
| SMC5 | structural maintenance of chromosomes 5 | 0.030117 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0297402 |
| OLA1 | Obg-like ATPase 1 | 0.0296026 |
| RANBP9 | RAN binding protein 9 | 0.0290675 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0289917 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0288315 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0288123 |
| TOP1 | topoisomerase (DNA) I | 0.0285341 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0285095 |
| DCAF6 | DDB1 and CUL4 associated factor 6 | 0.0284961 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0283955 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0282573 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0281708 |
| KAT6A | K(lysine) acetyltransferase 6A | 0.0280962 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0279676 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0279384 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.230311 |
| FN1 | fibronectin 1 | -0.210487 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.203565 |
| APOB | apolipoprotein B | -0.147272 |
| MT2A | metallothionein 2A | -0.127997 |
| GPC3 | glypican 3 | -0.111263 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0871137 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0853119 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0820834 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.0724946 |
| GPC6 | glypican 6 | -0.071111 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0703443 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0692756 |
| TMSB10 | thymosin beta 10 | -0.0643179 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0633545 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0624196 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0590763 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0558901 |
| APOA2 | apolipoprotein A-II | -0.053648 |
| EGR1 | early growth response 1 | -0.053285 |
| C3 | complement component 3 | -0.0526464 |
| EHBP1 | EH domain binding protein 1 | -0.0510377 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0510274 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0488669 |
| RPS19 | ribosomal protein S19 | -0.0488578 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0482851 |
| RNF213 | ring finger protein 213 | -0.046469 |
| H1-0 | H1.0 linker histone | -0.0461907 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0438268 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0430968 |
| FRMD5 | FERM domain containing 5 | -0.0426936 |
| FTL | ferritin, light polypeptide | -0.0408479 |
| DNAH17 | dynein, axonemal, heavy chain 17 | -0.0401824 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.038574 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0382122 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | -0.0379895 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0377411 |
| RPS24 | ribosomal protein S24 | -0.036568 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0363282 |
| ATXN1 | ataxin 1 | -0.0358944 |
| RASGRF2 | Ras protein-specific guanine nucleotide-releasing factor 2 | -0.0356658 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0340551 |
| A2M | alpha-2-macroglobulin | -0.0326136 |
| GK | glycerol kinase | -0.0325157 |
| KLF6 | Kruppel-like factor 6 | -0.0320008 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.031574 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0313193 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0309199 |
| RPL31 | ribosomal protein L31 | -0.0305447 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0304003 |
| AHSG | alpha-2-HS-glycoprotein | -0.0298905 |
| RPL11 | ribosomal protein L11 | -0.0297253 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0294028 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0293162 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0292807 |
| TFRC | transferrin receptor | -0.0292567 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | -0.0290323 |
| RPS8 | ribosomal protein S8 | -0.0286024 |
| CTSB | cathepsin B | -0.0285154 |
| RUNX1 | runt-related transcription factor 1 | -0.0282075 |
| PTCHD4 | patched domain containing 4 | -0.0281851 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0277028 |
| ITGB5 | integrin, beta 5 | -0.0276585 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0274598 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0273968 |
| RPL35A | ribosomal protein L35a | -0.0271171 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0264615 |
| PEG3 | paternally expressed 3 | -0.0260734 |
| RPS11 | ribosomal protein S11 | -0.0257324 |
| SYN3 | synapsin III | -0.025491 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0254808 |
| ARID3A | AT rich interactive domain 3A (BRIGHT-like) | -0.0254286 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0250813 |
| ITGA1 | integrin, alpha 1 | -0.0250523 |
| RPL28 | ribosomal protein L28 | -0.0241153 |
| HMGA1 | high mobility group AT-hook 1 | -0.0239768 |
| RPS13 | ribosomal protein S13 | -0.023934 |
| RPLP2 | ribosomal protein, large, P2 | -0.0236664 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0236567 |
| DOK6 | docking protein 6 | -0.0235482 |
| RPL36 | ribosomal protein L36 | -0.0233707 |
| ACTN4 | actinin, alpha 4 | -0.0232394 |
| RPL37A | ribosomal protein L37a | -0.023208 |
| PDGFB | platelet-derived growth factor beta polypeptide | -0.0231584 |
| DOCK1 | dedicator of cytokinesis 1 | -0.0230747 |
| ESF1 | ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) | -0.0229216 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0229151 |
| NPR2 | natriuretic peptide receptor 2 | -0.0228618 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.022658 |
| IER3 | immediate early response 3 | -0.0223123 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0222953 |
| GNAS | GNAS complex locus | -0.0215918 |
| RAI14 | retinoic acid induced 14 | -0.0215419 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0214145 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | -0.0213384 |
| OSMR | oncostatin M receptor | -0.0211426 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0210646 |
| NDRG1 | N-myc downstream regulated 1 | -0.0205974 |
| APOC2 | apolipoprotein C-II | -0.0205583 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.0205277 |
