crizotinib_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description crizotinib perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the crizotinib_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FGFR2 fibroblast growth factor receptor 2 0.0754988
FNDC3B fibronectin type III domain containing 3B 0.0583121
GMDS GDP-mannose 4,6-dehydratase 0.0492453
DSPP dentin sialophosphoprotein 0.0490701
ARHGAP32 Rho GTPase activating protein 32 0.040569
ATXN1 ataxin 1 0.0403855
LMO7 LIM domain 7 0.0388654
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0376425
LPP LIM domain containing preferred translocation partner in lipoma 0.03623
EXT1 exostosin glycosyltransferase 1 0.0359706
EZR ezrin 0.0339563
MYH9 myosin, heavy chain 9, non-muscle 0.0331638
ZFAND3 zinc finger, AN1-type domain 3 0.0329
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0312644
PTPRK protein tyrosine phosphatase, receptor type, K 0.0305053
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0296867
ANXA11 annexin A11 0.0279494
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0275442
PRELID2 PRELI domain containing 2 0.0273821
BIRC6 baculoviral IAP repeat containing 6 0.0261662
SAMD12 sterile alpha motif domain containing 12 0.0258891
CTNND1 catenin (cadherin-associated protein), delta 1 0.0256378
MACF1 microtubule-actin crosslinking factor 1 0.0255023
KDM6A lysine (K)-specific demethylase 6A 0.0253805
SEPTIN9 septin 9 0.0244672
ZC3H12B zinc finger CCCH-type containing 12B 0.0234945
BTBD9 BTB (POZ) domain containing 9 0.023172
ATF7IP2 activating transcription factor 7 interacting protein 2 0.023144
GOLGB1 golgin B1 0.0228414
ANKRD10 ankyrin repeat domain 10 0.0224878
EXOC4 exocyst complex component 4 0.0222062
AFDN afadin, adherens junction formation factor 0.0221436
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0219461
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.021817
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.021741
KDM4C lysine (K)-specific demethylase 4C 0.0216913
CEMIP cell migration inducing protein, hyaluronan binding 0.0216475
USP9X ubiquitin specific peptidase 9, X-linked 0.0216454
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 0.0215078
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0214694
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0212248
STK24 serine/threonine kinase 24 0.0211487
CAPN8 calpain 8 0.0209315
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0208266
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0207187
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0207029
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0202757
SPAG9 sperm associated antigen 9 0.0202709
SMAD3 SMAD family member 3 0.0200983
VMP1 vacuole membrane protein 1 0.01979
MED13L mediator complex subunit 13-like 0.0196726
PUM2 pumilio RNA-binding family member 2 0.0196587
FNIP1 folliculin interacting protein 1 0.0196362
KDM3A lysine (K)-specific demethylase 3A 0.0195305
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0194004
AHR aryl hydrocarbon receptor 0.0191932
ANKRD11 ankyrin repeat domain 11 0.0191032
MYO6 myosin VI 0.0190483
DSCAM Down syndrome cell adhesion molecule 0.0189828
SNX9 sorting nexin 9 0.018981
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0189617
CEMIP2 cell migration inducing hyaluronidase 2 0.0187073
CTBP2 C-terminal binding protein 2 0.0186594
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0184627
KMT2C lysine (K)-specific methyltransferase 2C 0.0184334
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0183701
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.018357
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0182797
PHF3 PHD finger protein 3 0.0182332
PMM2 phosphomannomutase 2 0.018114
TRIP12 thyroid hormone receptor interactor 12 0.0178051
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0176725
OGA O-GlcNAcase 0.0175957
ZNF292 zinc finger protein 292 0.0174262
VCL vinculin 0.0172624
CDK13 cyclin-dependent kinase 13 0.0172271
RBM39 RNA binding motif protein 39 0.0171847
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0171219
EIF4B eukaryotic translation initiation factor 4B 0.0170707
ARHGAP42 Rho GTPase activating protein 42 0.0170423
EIF4A2 eukaryotic translation initiation factor 4A2 0.0170066
MYOF myoferlin 0.0170022
KIF16B kinesin family member 16B 0.016836
AVL9 AVL9 homolog (S. cerevisiase) 0.0167906
CEP95 centrosomal protein 95kDa 0.0167417
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.016598
MSI2 musashi RNA-binding protein 2 0.016557
TC2N tandem C2 domains, nuclear 0.0165286
FNDC3A fibronectin type III domain containing 3A 0.0164273
YAP1 Yes-associated protein 1 0.0163632
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0163273
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0162253
SHB Src homology 2 domain containing adaptor protein B 0.0161459
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0161366
UBE2H ubiquitin-conjugating enzyme E2H 0.0161224
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.015973
CADPS2 Ca++-dependent secretion activator 2 0.0159444
CDK19 cyclin-dependent kinase 19 0.0158714
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0157759
FGD4 FYVE, RhoGEF and PH domain containing 4 0.015741

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.202091
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.161241
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.134972
PTMA prothymosin, alpha -0.111116
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.106062
FTL ferritin, light polypeptide -0.0872035
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0857288
S100A6 S100 calcium binding protein A6 -0.082658
RPL35A ribosomal protein L35a -0.0811078
RPS6 ribosomal protein S6 -0.0795609
EIF1 eukaryotic translation initiation factor 1 -0.0760943
RPS19 ribosomal protein S19 -0.0746032
TPT1 tumor protein, translationally-controlled 1 -0.0721372
RPL23 ribosomal protein L23 -0.0710779
B2M beta-2-microglobulin -0.0708763
S100A10 S100 calcium binding protein A10 -0.0692805
PDIA3 protein disulfide isomerase family A, member 3 -0.0654261
RPS3 ribosomal protein S3 -0.0630141
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0622386
IFI27 interferon, alpha-inducible protein 27 -0.059332
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0581466
AGR2 anterior gradient 2 -0.0580555
LOC112694756 uncharaterized LOC112694756 -0.0572589
POTEF POTE ankyrin domain family, member F -0.0564999
RPLP1 ribosomal protein, large, P1 -0.055091
RPS8 ribosomal protein S8 -0.0540891
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0528454
RPS21 ribosomal protein S21 -0.0520695
CALR calreticulin -0.0508535
S100P S100 calcium binding protein P -0.05081
S100A11 S100 calcium binding protein A11 -0.0498749
S100A9 S100 calcium binding protein A9 -0.0497734
PKM pyruvate kinase, muscle -0.0488249
KRT18 keratin 18, type I -0.0481126
HLA-A major histocompatibility complex, class I, A -0.0473975
RPL12 ribosomal protein L12 -0.0461319
AGR3 anterior gradient 3 -0.0455388
CLDN7 claudin 7 -0.0444119
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0444095
RPL19 ribosomal protein L19 -0.0443923
AREG amphiregulin -0.0433227
RPL18 ribosomal protein L18 -0.0430672
PFN1 profilin 1 -0.0427614
RPS25 ribosomal protein S25 -0.0404883
HMGA1 high mobility group AT-hook 1 -0.0401445
GSTP1 glutathione S-transferase pi 1 -0.0400565
ATF5 activating transcription factor 5 -0.0397762
LCN2 lipocalin 2 -0.039721
TMC5 transmembrane channel-like 5 -0.0393769
RPS16 ribosomal protein S16 -0.0384794
RPL8 ribosomal protein L8 -0.0384619
RPL28 ribosomal protein L28 -0.0370677
PDIA6 protein disulfide isomerase family A, member 6 -0.0360635
ACTG1 actin gamma 1 -0.0358132
EMP1 epithelial membrane protein 1 -0.0355201
RPL26 ribosomal protein L26 -0.0354173
RPL34 ribosomal protein L34 -0.0351392
IFITM3 interferon induced transmembrane protein 3 -0.034801
RPL35 ribosomal protein L35 -0.0347833
IFI6 interferon, alpha-inducible protein 6 -0.0334078
NDRG1 N-myc downstream regulated 1 -0.0332592
ENO1 enolase 1, (alpha) -0.0331359
FTH1 ferritin, heavy polypeptide 1 -0.0331166
CBX3 chromobox homolog 3 -0.0331089
GNAS GNAS complex locus -0.0325957
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0324712
PDIA4 protein disulfide isomerase family A, member 4 -0.0321385
SERF2 small EDRK-rich factor 2 -0.0320802
H1-0 H1.0 linker histone -0.0315938
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0314769
EPCAM epithelial cell adhesion molecule -0.0310283
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.030977
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0306195
RPL9 ribosomal protein L9 -0.0305286
RPL11 ribosomal protein L11 -0.0302739
PGK1 phosphoglycerate kinase 1 -0.0300699
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0299588
LMNA lamin A/C -0.0299127
RPS24 ribosomal protein S24 -0.0298053
RPS12 ribosomal protein S12 -0.0295979
HLA-B major histocompatibility complex, class I, B -0.0294303
MYL12B myosin, light chain 12B, regulatory -0.0293274
KRT7 keratin 7, type II -0.0293122
RPS17 ribosomal protein S17 -0.0290015
KRT19 keratin 19, type I -0.0289047
SEC61G Sec61 gamma subunit -0.0288782
ANXA1 annexin A1 -0.0288698
RPS11 ribosomal protein S11 -0.0288566
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0285745
DEK DEK proto-oncogene -0.0284467
RPLP2 ribosomal protein, large, P2 -0.028364
RPS14 ribosomal protein S14 -0.0281454
RPL32 ribosomal protein L32 -0.0275494
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0271459
RPS27 ribosomal protein S27 -0.0268247
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0264973
ATP5F1E ATP synthase F1 subunit epsilon -0.0264609
MUC1 mucin 1, cell surface associated -0.0264344
TFF2 trefoil factor 2 -0.0264053
RPL7A ribosomal protein L7a -0.0261822