crizotinib_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description crizotinib perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the crizotinib_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EPS8 epidermal growth factor receptor pathway substrate 8 0.0585253
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0573276
ANKRD11 ankyrin repeat domain 11 0.0553008
VEGFA vascular endothelial growth factor A 0.0525341
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0509815
MUC6 mucin 6, oligomeric mucus/gel-forming 0.0490533
ZNF292 zinc finger protein 292 0.0485484
FAM13A family with sequence similarity 13, member A 0.0473782
NDRG1 N-myc downstream regulated 1 0.0472805
RNF145 ring finger protein 145 0.0452063
KDM6A lysine (K)-specific demethylase 6A 0.0450277
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0434446
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0432267
ZFAND3 zinc finger, AN1-type domain 3 0.0423541
NEBL nebulette 0.0422149
FNDC3B fibronectin type III domain containing 3B 0.0411236
WAC WW domain containing adaptor with coiled-coil 0.0391604
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0391541
GRB10 growth factor receptor-bound protein 10 0.0389744
KMT2E lysine (K)-specific methyltransferase 2E 0.038932
CD46 CD46 molecule, complement regulatory protein 0.0385766
MED13L mediator complex subunit 13-like 0.0378364
RBM39 RNA binding motif protein 39 0.0374746
INSIG1 insulin induced gene 1 0.0373453
RREB1 ras responsive element binding protein 1 0.0371962
CCNL1 cyclin L1 0.0371623
EZR ezrin 0.0356387
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0351215
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0348767
MYO5B myosin VB 0.0333618
TFG TRK-fused gene 0.0327517
LMO7 LIM domain 7 0.0324187
PRELID2 PRELI domain containing 2 0.0323013
ABHD2 abhydrolase domain containing 2 0.0314211
CCNY cyclin Y 0.0308467
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0289043
NEK7 NIMA-related kinase 7 0.0288253
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0287067
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0284949
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0284358
TRA2A transformer 2 alpha homolog (Drosophila) 0.0283827
PTBP3 polypyrimidine tract binding protein 3 0.0282853
OSBPL9 oxysterol binding protein-like 9 0.0281574
LPP LIM domain containing preferred translocation partner in lipoma 0.0277905
MARCHF6 membrane associated ring-CH-type finger 6 0.0277338
UBE2H ubiquitin-conjugating enzyme E2H 0.0277325
EREG epiregulin 0.0276133
MACF1 microtubule-actin crosslinking factor 1 0.027375
ATXN1 ataxin 1 0.0271892
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0271113
CTBP2 C-terminal binding protein 2 0.0267053
SREBF2 sterol regulatory element binding transcription factor 2 0.026119
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0256098
ANXA11 annexin A11 0.025582
MYH9 myosin, heavy chain 9, non-muscle 0.025577
NCKAP1 NCK-associated protein 1 0.0253266
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.0251773
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0251603
NAMPT nicotinamide phosphoribosyltransferase 0.0251495
DSCAM Down syndrome cell adhesion molecule 0.0245648
PDLIM5 PDZ and LIM domain 5 0.0243669
RYBP RING1 and YY1 binding protein 0.0242532
SETD5 SET domain containing 5 0.0240065
CTNND1 catenin (cadherin-associated protein), delta 1 0.0239788
PCBP2 poly(rC) binding protein 2 0.0238794
PICALM phosphatidylinositol binding clathrin assembly protein 0.0237186
SNX9 sorting nexin 9 0.0235751
PUM1 pumilio RNA-binding family member 1 0.0232469
NUP58 nucleoporin 58 0.0231434
HELZ helicase with zinc finger 0.0230665
EWSR1 EWS RNA-binding protein 1 0.0230047
COPA coatomer protein complex, subunit alpha 0.0228278
PELI1 pellino E3 ubiquitin protein ligase 1 0.0225983
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0225177
PUM2 pumilio RNA-binding family member 2 0.0222921
TSC22D2 TSC22 domain family, member 2 0.0222625
BCLAF1 BCL2-associated transcription factor 1 0.0221307
RAP1B RAP1B, member of RAS oncogene family 0.0219776
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0216436
UBA6 ubiquitin-like modifier activating enzyme 6 0.0215964
USP6NL USP6 N-terminal like 0.0215404
ADAM17 ADAM metallopeptidase domain 17 0.0214309
ARHGAP26 Rho GTPase activating protein 26 0.0214261
RNF43 ring finger protein 43 0.021359
PLAUR plasminogen activator, urokinase receptor 0.0213248
SPRED2 sprouty-related, EVH1 domain containing 2 0.02119
YME1L1 YME1-like 1 ATPase 0.0210475
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0210311
PARD3 par-3 family cell polarity regulator 0.0209724
CEMIP2 cell migration inducing hyaluronidase 2 0.0205981
USP3 ubiquitin specific peptidase 3 0.0204745
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0204385
FOXJ3 forkhead box J3 0.020395
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0203681
EIF4B eukaryotic translation initiation factor 4B 0.0203588
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.020284
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0202373
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.0200225
FDPS farnesyl diphosphate synthase 0.0200133
ERRFI1 ERBB receptor feedback inhibitor 1 0.0200123

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.25141
PTMA prothymosin, alpha -0.232484
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.141174
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.139134
TMSB10 thymosin beta 10 -0.107811
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.103765
NPSR1 neuropeptide S receptor 1 -0.0771029
NALF1 NALCN channel auxiliary factor 1 -0.0740522
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0694171
KRT18 keratin 18, type I -0.0668353
TPT1 tumor protein, translationally-controlled 1 -0.0645331
LDHA lactate dehydrogenase A -0.064068
EIF1 eukaryotic translation initiation factor 1 -0.0608679
LOC112694756 uncharaterized LOC112694756 -0.0608509
ANXA2 annexin A2 -0.0586017
RPLP1 ribosomal protein, large, P1 -0.0569232
AHNAK AHNAK nucleoprotein -0.0561809
PIGR polymeric immunoglobulin receptor -0.0558139
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0541504
FTL ferritin, light polypeptide -0.0535075
RPL12 ribosomal protein L12 -0.0526322
RPS8 ribosomal protein S8 -0.0521455
RPS6 ribosomal protein S6 -0.0502706
H1-0 H1.0 linker histone -0.0491918
EPCAM epithelial cell adhesion molecule -0.0482905
GDF15 growth differentiation factor 15 -0.0472809
S100P S100 calcium binding protein P -0.0465308
RPL35A ribosomal protein L35a -0.046391
CADPS Ca++-dependent secretion activator -0.045045
AGR2 anterior gradient 2 -0.0448402
GREB1L growth regulation by estrogen in breast cancer-like -0.0437436
RPLP0 ribosomal protein, large, P0 -0.0430455
S100A6 S100 calcium binding protein A6 -0.042594
RPL34 ribosomal protein L34 -0.0424267
RPL11 ribosomal protein L11 -0.0413314
KIF5B kinesin family member 5B -0.0413073
CANX calnexin -0.0411055
EHBP1 EH domain binding protein 1 -0.0404228
FAT1 FAT atypical cadherin 1 -0.0403745
RPS19 ribosomal protein S19 -0.0402219
RPLP2 ribosomal protein, large, P2 -0.0394007
RPS24 ribosomal protein S24 -0.0390989
S100A10 S100 calcium binding protein A10 -0.0361074
CCND1 cyclin D1 -0.0359628
ONECUT3 one cut homeobox 3 -0.0358462
GCC2 GRIP and coiled-coil domain containing 2 -0.0357979
VDAC1 voltage-dependent anion channel 1 -0.0356269
ARF1 ADP-ribosylation factor 1 -0.035423
RPL36 ribosomal protein L36 -0.035032
RPL19 ribosomal protein L19 -0.0347439
PTPRK protein tyrosine phosphatase, receptor type, K -0.0343253
RPL23 ribosomal protein L23 -0.0339734
RPL8 ribosomal protein L8 -0.0338497
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0332897
RPL32 ribosomal protein L32 -0.0331041
RPS3 ribosomal protein S3 -0.0326492
RPL26 ribosomal protein L26 -0.0321261
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0311678
MLEC malectin -0.031007
RPL13A ribosomal protein L13a -0.0308587
PERP PERP, TP53 apoptosis effector -0.0304789
EMP1 epithelial membrane protein 1 -0.0303103
RPL31 ribosomal protein L31 -0.0297499
POF1B premature ovarian failure, 1B -0.0293613
RPL27A ribosomal protein L27a -0.0291238
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0289985
RPS27A ribosomal protein S27a -0.0286321
RRBP1 ribosome binding protein 1 -0.028406
RPS29 ribosomal protein S29 -0.0283321
HMGA1 high mobility group AT-hook 1 -0.0282814
ENO1 enolase 1, (alpha) -0.0282378
HDLBP high density lipoprotein binding protein -0.0277496
FLNB filamin B, beta -0.027519
RPL18 ribosomal protein L18 -0.0272921
ACTG1 actin gamma 1 -0.0270862
RPS25 ribosomal protein S25 -0.0266594
RACK1 receptor for activated C kinase 1 -0.0265918
RPS16 ribosomal protein S16 -0.0264633
RPL7A ribosomal protein L7a -0.0263843
FERMT1 fermitin family member 1 -0.0263161
DSG2 desmoglein 2 -0.0262872
TXNIP thioredoxin interacting protein -0.0261581
TNS4 tensin 4 -0.0260698
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0257009
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0254918
RPL28 ribosomal protein L28 -0.025447
LGALS4 lectin, galactoside-binding, soluble, 4 -0.025281
RPS23 ribosomal protein S23 -0.024803
RPS13 ribosomal protein S13 -0.0247148
PATJ PATJ crumbs cell polarity complex component -0.0240591
MAML2 mastermind-like 2 (Drosophila) -0.0239114
TTC3 tetratricopeptide repeat domain 3 -0.0238
IER3 immediate early response 3 -0.0237153
NRN1 neuritin 1 -0.023448
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 -0.0232962
NAP1L1 nucleosome assembly protein 1-like 1 -0.0232016
UBC ubiquitin C -0.0230248
RPS27 ribosomal protein S27 -0.0229459
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0227708
CD44 CD44 molecule (Indian blood group) -0.0226099