| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | crizotinib perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the crizotinib_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | 0.123526 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.103553 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.083794 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0834887 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0817382 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0730741 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0668525 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0654345 |
| JMJD1C | jumonji domain containing 1C | 0.0615071 |
| CAPRIN2 | caprin family member 2 | 0.0581864 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0580666 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0564763 |
| RTN4 | reticulon 4 | 0.0557793 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.054945 |
| RCOR1 | REST corepressor 1 | 0.0545294 |
| SPAG9 | sperm associated antigen 9 | 0.0537669 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0525336 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0512089 |
| APP | amyloid beta (A4) precursor protein | 0.0509103 |
| CENPF | centromere protein F, 350/400kDa | 0.047815 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0469086 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0465459 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0460901 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0450483 |
| AHNAK | AHNAK nucleoprotein | 0.0446084 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.04347 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0434663 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0429102 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0428566 |
| USP34 | ubiquitin specific peptidase 34 | 0.0427947 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0426442 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.04118 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0410907 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0409216 |
| TMEM41B | transmembrane protein 41B | 0.0407024 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.040449 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0400241 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0387376 |
| RBM39 | RNA binding motif protein 39 | 0.0383449 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0376374 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0375895 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0375102 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0373768 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0372707 |
| OGA | O-GlcNAcase | 0.0371208 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.037088 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0370129 |
| FMNL2 | formin-like 2 | 0.036989 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0369202 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0368233 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0367294 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0366056 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0363457 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0358178 |
| MATR3 | matrin 3 | 0.0356088 |
| TOP1 | topoisomerase (DNA) I | 0.0351574 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0349754 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0348015 |
| RAPGEF6 | Rap guanine nucleotide exchange factor (GEF) 6 | 0.0346707 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0343779 |
| VCL | vinculin | 0.034314 |
| DNAJB6 | DnaJ (Hsp40) homolog, subfamily B, member 6 | 0.0342882 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0341962 |
| MKI67 | marker of proliferation Ki-67 | 0.0341782 |
| SRPK2 | SRSF protein kinase 2 | 0.0340089 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.033993 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0335499 |
| FNIP1 | folliculin interacting protein 1 | 0.0333979 |
| ERBIN | erbb2 interacting protein | 0.0333239 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | 0.0332014 |
| CUL3 | cullin 3 | 0.0331776 |
| OLA1 | Obg-like ATPase 1 | 0.0327356 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0321844 |
| ECT2 | epithelial cell transforming 2 | 0.0320327 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0319645 |
| IPO7 | importin 7 | 0.0319078 |
| EREG | epiregulin | 0.0317378 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0313495 |
| AFF4 | AF4/FMR2 family, member 4 | 0.031 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0302994 |
| KCMF1 | potassium channel modulatory factor 1 | 0.0300718 |
| TNPO1 | transportin 1 | 0.030045 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0299726 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0299461 |
| MEMO1 | mediator of cell motility 1 | 0.0299299 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | 0.0297762 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0293102 |
| QKI | QKI, KH domain containing, RNA binding | 0.0288276 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.028769 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0285977 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0283735 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0279709 |
| NCKAP1 | NCK-associated protein 1 | 0.0279634 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0272726 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0271767 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0271277 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0271172 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.0270852 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0269837 |
| RASA2 | RAS p21 protein activator 2 | 0.0267534 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.132847 |
| PTMA | prothymosin, alpha | -0.117859 |
| TMSB10 | thymosin beta 10 | -0.108368 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.100766 |
| MT2A | metallothionein 2A | -0.0906805 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0756719 |
| TP63 | tumor protein p63 | -0.0746974 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0674246 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0673745 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0634031 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0550656 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0542538 |
| POTEF | POTE ankyrin domain family, member F | -0.0505656 |
| RNF213 | ring finger protein 213 | -0.0497607 |
| EFNA5 | ephrin-A5 | -0.0485257 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0463333 |
| CD44 | CD44 molecule (Indian blood group) | -0.0451074 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0446334 |
| FTL | ferritin, light polypeptide | -0.0436733 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0436054 |
| EPHA4 | EPH receptor A4 | -0.0432522 |
| RPS6 | ribosomal protein S6 | -0.0403973 |
| HLA-B | major histocompatibility complex, class I, B | -0.0398104 |
| RPS8 | ribosomal protein S8 | -0.0393669 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0393276 |
| CADM2 | cell adhesion molecule 2 | -0.0386249 |
| RPS12 | ribosomal protein S12 | -0.0385939 |
| MT1E | metallothionein 1E | -0.038191 |
| TXNIP | thioredoxin interacting protein | -0.037789 |
| MT1X | metallothionein 1X | -0.0375617 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0367988 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0353999 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0349891 |
| RPS19 | ribosomal protein S19 | -0.0349178 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0346263 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0333331 |
| RPS3 | ribosomal protein S3 | -0.0320652 |
| RPL36 | ribosomal protein L36 | -0.0315577 |
| RPL18 | ribosomal protein L18 | -0.030876 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0306944 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | -0.0299158 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | -0.0298244 |
| TNS3 | tensin 3 | -0.0297695 |
| RPL35 | ribosomal protein L35 | -0.0297325 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.0294435 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0289597 |
| RPL12 | ribosomal protein L12 | -0.0289002 |
| HMGA1 | high mobility group AT-hook 1 | -0.0278772 |
| TGM2 | transglutaminase 2 | -0.0267319 |
| NDRG1 | N-myc downstream regulated 1 | -0.0265462 |
| RPL35A | ribosomal protein L35a | -0.0262045 |
| DNER | delta/notch-like EGF repeat containing | -0.0255698 |
| HLA-A | major histocompatibility complex, class I, A | -0.0254969 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0254211 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0250144 |
| CALR | calreticulin | -0.0242725 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0240278 |
| RPL37A | ribosomal protein L37a | -0.0240179 |
| PLIN2 | perilipin 2 | -0.0230684 |
| ANKRD26 | ankyrin repeat domain 26 | -0.0230621 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0228759 |
| GYS1 | glycogen synthase 1 (muscle) | -0.022696 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0222258 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0214939 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0214127 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0213095 |
| TRIM56 | tripartite motif containing 56 | -0.0212859 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0210187 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0206347 |
| MYOF | myoferlin | -0.0202596 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | -0.0201248 |
| RPLP2 | ribosomal protein, large, P2 | -0.0200733 |
| COL5A2 | collagen, type V, alpha 2 | -0.0200447 |
| PLOD1 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 | -0.0198335 |
| ZNF638 | zinc finger protein 638 | -0.0196957 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0196681 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0193978 |
| SLK | STE20-like kinase | -0.0193797 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | -0.0192253 |
| RIGI | RNA sensor RIG-I | -0.0187702 |
| RPL26 | ribosomal protein L26 | -0.0187112 |
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | -0.0186627 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | -0.0185787 |
| CFAP299 | cilia and flagella associated protein 299 | -0.0185589 |
| RPL34 | ribosomal protein L34 | -0.0185432 |
| GOLGA4 | golgin A4 | -0.0183031 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0182896 |
| RPS2 | ribosomal protein S2 | -0.0181893 |
| RPL19 | ribosomal protein L19 | -0.0181799 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0181308 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | -0.0179727 |
| GLG1 | golgi glycoprotein 1 | -0.0179329 |
| CBX3 | chromobox homolog 3 | -0.0177365 |
| RPL37 | ribosomal protein L37 | -0.0176755 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | -0.0175936 |
| LMNA | lamin A/C | -0.0169858 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0169572 |
| PCDH1 | protocadherin 1 | -0.0169377 |
| ECE1 | endothelin converting enzyme 1 | -0.0168747 |
| ANGPTL4 | angiopoietin-like 4 | -0.0168122 |
