| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | crizotinib perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the crizotinib_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0884534 |
| TXNRD1 | thioredoxin reductase 1 | 0.0730849 |
| FAM13A | family with sequence similarity 13, member A | 0.0730578 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0690483 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.068874 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0667841 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0628354 |
| MKI67 | marker of proliferation Ki-67 | 0.0627766 |
| LRP1B | low density lipoprotein receptor-related protein 1B | 0.0579569 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0566735 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0552502 |
| NGLY1 | N-glycanase 1 | 0.0517978 |
| ARRDC3 | arrestin domain containing 3 | 0.051054 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0506392 |
| OGA | O-GlcNAcase | 0.0504787 |
| RUNX1 | runt-related transcription factor 1 | 0.0503699 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0488285 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0483081 |
| UVRAG | UV radiation resistance associated | 0.0475418 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0469172 |
| SPAG9 | sperm associated antigen 9 | 0.0468556 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0407048 |
| FNIP1 | folliculin interacting protein 1 | 0.0397217 |
| HELZ | helicase with zinc finger | 0.0396876 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0395737 |
| SUCO | SUN domain containing ossification factor | 0.0390756 |
| ZNF292 | zinc finger protein 292 | 0.0384346 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0382884 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0380891 |
| RBM39 | RNA binding motif protein 39 | 0.0377057 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0376167 |
| TMEM165 | transmembrane protein 165 | 0.0371141 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0368095 |
| KCMF1 | potassium channel modulatory factor 1 | 0.0362232 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0360593 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | 0.0355235 |
| CES1 | carboxylesterase 1 | 0.0353633 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0343826 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0335388 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.032982 |
| ANO6 | anoctamin 6 | 0.0329014 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0328059 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0320127 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0319253 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0318312 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0316806 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0313819 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0313659 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0313219 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0312542 |
| PUM2 | pumilio RNA-binding family member 2 | 0.031246 |
| USP34 | ubiquitin specific peptidase 34 | 0.030419 |
| NPTN | neuroplastin | 0.0301056 |
| YEATS2 | YEATS domain containing 2 | 0.0295635 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0295156 |
| ATP13A3 | ATPase type 13A3 | 0.0292084 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | 0.0291909 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0288122 |
| KIAA1217 | KIAA1217 | 0.028655 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0284979 |
| TFG | TRK-fused gene | 0.0282952 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0281825 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0281111 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0280238 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0273605 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0271175 |
| DENND4A | DENN/MADD domain containing 4A | 0.0268674 |
| RPL4 | ribosomal protein L4 | 0.0266004 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0263874 |
| SMC4 | structural maintenance of chromosomes 4 | 0.026365 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.0263138 |
| ATG14 | autophagy related 14 | 0.0260122 |
| RNF145 | ring finger protein 145 | 0.0259934 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0259086 |
| UBE2O | ubiquitin-conjugating enzyme E2O | 0.0257145 |
| CEP350 | centrosomal protein 350kDa | 0.0257058 |
| KIAA1328 | KIAA1328 | 0.0256909 |
| TBK1 | TANK-binding kinase 1 | 0.0253272 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | 0.0252376 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.0251812 |
| WDR45B | WD repeat domain 45B | 0.0251022 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0245698 |
| MED13 | mediator complex subunit 13 | 0.0245512 |
| PCBP2 | poly(rC) binding protein 2 | 0.0245243 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0243385 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0241212 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0239827 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0239238 |
| MON2 | MON2 homolog (S. cerevisiae) | 0.0238043 |
| NUP58 | nucleoporin 58 | 0.0237693 |
| JMJD1C | jumonji domain containing 1C | 0.0237232 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0237012 |
| NDE1 | nudE neurodevelopment protein 1 | 0.0236344 |
| TMCO3 | transmembrane and coiled-coil domains 3 | 0.0234574 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0233598 |
| PPP1R15B | protein phosphatase 1, regulatory subunit 15B | 0.023241 |
| TENT2 | terminal nucleotidyltransferase 2 | 0.0228723 |
| DTNA | dystrobrevin, alpha | 0.0228427 |
| ZNF638 | zinc finger protein 638 | 0.0228358 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.0227429 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.180647 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.177649 |
| LAMC2 | laminin, gamma 2 | -0.113786 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.110627 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.107695 |
| ASPH | aspartate beta-hydroxylase | -0.106855 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.106129 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.102688 |
| LMO7 | LIM domain 7 | -0.0975132 |
| ACTG1 | actin gamma 1 | -0.0942246 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0896851 |
| EGR1 | early growth response 1 | -0.0890626 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.085869 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0833167 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0815841 |
| EGFR | epidermal growth factor receptor | -0.0751596 |
| NDRG1 | N-myc downstream regulated 1 | -0.0749704 |
| GRAMD1B | GRAM domain containing 1B | -0.073835 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0696056 |
| ANXA2 | annexin A2 | -0.0688103 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.066447 |
| LAMA4 | laminin, alpha 4 | -0.06411 |
| PKM | pyruvate kinase, muscle | -0.0628848 |
| RNF213 | ring finger protein 213 | -0.061991 |
| S100A10 | S100 calcium binding protein A10 | -0.0614065 |
| OSMR | oncostatin M receptor | -0.059657 |
| PTMA | prothymosin, alpha | -0.0593108 |
| SCEL | sciellin | -0.0587858 |
| CCND1 | cyclin D1 | -0.0548186 |
| EFNA5 | ephrin-A5 | -0.0531088 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0522976 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0522299 |
| FTL | ferritin, light polypeptide | -0.0493276 |
| CST3 | cystatin C | -0.048668 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.04832 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.047132 |
| STC1 | stanniocalcin 1 | -0.0457623 |
| KRT7 | keratin 7, type II | -0.0456137 |
| KRT18 | keratin 18, type I | -0.0452833 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.044977 |
| AHNAK | AHNAK nucleoprotein | -0.043788 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0428511 |
| RPS3 | ribosomal protein S3 | -0.0420321 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0417634 |
| MYO1E | myosin IE | -0.0414762 |
| AREG | amphiregulin | -0.0413023 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0403677 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0399711 |
| FOXP1 | forkhead box P1 | -0.0398384 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0395985 |
| TPM4 | tropomyosin 4 | -0.039583 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0387411 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0374372 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0360858 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0353527 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0346476 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0345267 |
| MYOF | myoferlin | -0.034505 |
| SMYD3 | SET and MYND domain containing 3 | -0.0342758 |
| LDHA | lactate dehydrogenase A | -0.0342516 |
| CAV2 | caveolin 2 | -0.0336159 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0332274 |
| S100A11 | S100 calcium binding protein A11 | -0.0325557 |
| HLA-B | major histocompatibility complex, class I, B | -0.0323459 |
| TNS3 | tensin 3 | -0.0322694 |
| VCL | vinculin | -0.0319744 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0313265 |
| CUX1 | cut-like homeobox 1 | -0.0312649 |
| SEC61G | Sec61 gamma subunit | -0.0310502 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0308466 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0307656 |
| CMIP | c-Maf inducing protein | -0.0307398 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.0306221 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0302612 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.0301578 |
| MT2A | metallothionein 2A | -0.0301578 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0297214 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0296612 |
| MYO1D | myosin ID | -0.0289591 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0288869 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0284645 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0284275 |
| RAB10 | RAB10, member RAS oncogene family | -0.027903 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0278152 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.027612 |
| PM20D1 | peptidase M20 domain containing 1 | -0.0273231 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0272186 |
| NTSR1 | neurotensin receptor 1 (high affinity) | -0.0272002 |
| FLNB | filamin B, beta | -0.0269144 |
| MCL1 | myeloid cell leukemia 1 | -0.0267568 |
| ENO1 | enolase 1, (alpha) | -0.0267313 |
| RPL35A | ribosomal protein L35a | -0.0267264 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0264526 |
| KRT19 | keratin 19, type I | -0.0263952 |
| STC2 | stanniocalcin 2 | -0.0262401 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0260431 |
| TJP1 | tight junction protein 1 | -0.0256232 |
| S100A9 | S100 calcium binding protein A9 | -0.0251526 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0251338 |
| ATP11A | ATPase, class VI, type 11A | -0.0250583 |
