| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | crizotinib perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the crizotinib_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.049943 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0446344 |
| PTK2 | protein tyrosine kinase 2 | 0.0442804 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0432434 |
| DENND4A | DENN/MADD domain containing 4A | 0.0425301 |
| USP3 | ubiquitin specific peptidase 3 | 0.0424456 |
| FAM168A | family with sequence similarity 168, member A | 0.0412527 |
| TXNRD1 | thioredoxin reductase 1 | 0.039379 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0369299 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0350496 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0345511 |
| WDR43 | WD repeat domain 43 | 0.0335523 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0318554 |
| RPL4 | ribosomal protein L4 | 0.0302505 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0296925 |
| ASPH | aspartate beta-hydroxylase | 0.0292244 |
| ZNF292 | zinc finger protein 292 | 0.0289094 |
| OSBPL9 | oxysterol binding protein-like 9 | 0.028096 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0271326 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0254535 |
| RBM39 | RNA binding motif protein 39 | 0.0254347 |
| SPAG9 | sperm associated antigen 9 | 0.025144 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.024538 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0241694 |
| CYRIB | CYFIP related Rac1 interactor B | 0.0241149 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0240685 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0232621 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0231863 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0231324 |
| OLA1 | Obg-like ATPase 1 | 0.0228589 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0225739 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0224214 |
| MTMR3 | myotubularin related protein 3 | 0.0223812 |
| TFG | TRK-fused gene | 0.0223509 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0222354 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.021342 |
| JAK1 | Janus kinase 1 | 0.0213017 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0210642 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0209681 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0208312 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0206154 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.020346 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0202775 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0200517 |
| RPL14 | ribosomal protein L14 | 0.0200004 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0197795 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0197228 |
| RTN4 | reticulon 4 | 0.0194816 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0191666 |
| RPS12 | ribosomal protein S12 | 0.0190655 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0188698 |
| RPS2 | ribosomal protein S2 | 0.018815 |
| NUDT21 | nudix (nucleoside diphosphate linked moiety X)-type motif 21 | 0.0184808 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0182708 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0181348 |
| EIF4A3 | eukaryotic translation initiation factor 4A3 | 0.0181221 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0180569 |
| RBM33 | RNA binding motif protein 33 | 0.0180569 |
| RYBP | RING1 and YY1 binding protein | 0.0180039 |
| SMG7 | SMG7 nonsense mediated mRNA decay factor | 0.0179574 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.0178673 |
| CYTH1 | cytohesin 1 | 0.0176871 |
| KPNA1 | karyopherin alpha 1 (importin alpha 5) | 0.0175122 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.01728 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0171123 |
| MAPK8 | mitogen-activated protein kinase 8 | 0.0165333 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.0165062 |
| YAP1 | Yes-associated protein 1 | 0.0164431 |
| IST1 | increased sodium tolerance 1 homolog (yeast) | 0.0163406 |
| PPME1 | protein phosphatase methylesterase 1 | 0.0162325 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.0161332 |
| APP | amyloid beta (A4) precursor protein | 0.0161234 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0160326 |
| IFRD1 | interferon-related developmental regulator 1 | 0.0160033 |
| NCKAP1 | NCK-associated protein 1 | 0.0157053 |
| USP15 | ubiquitin specific peptidase 15 | 0.0156918 |
| SMAP1 | small ArfGAP 1 | 0.0155692 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0154279 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0152827 |
| ATP6V1H | ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H | 0.0151978 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0151804 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0151273 |
| WIPF2 | WAS/WASL interacting protein family, member 2 | 0.0151252 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0150117 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0149911 |
| HBP1 | HMG-box transcription factor 1 | 0.0149771 |
| EWSR1 | EWS RNA-binding protein 1 | 0.0148724 |
| NEK7 | NIMA-related kinase 7 | 0.0148524 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0148427 |
| TMSB4X | thymosin beta 4, X-linked | 0.0146296 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0145829 |
| SMAD2 | SMAD family member 2 | 0.0144572 |
| RBM8A | RNA binding motif protein 8A | 0.0144161 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.014355 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0142926 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.014264 |
| RHEB | Ras homolog enriched in brain | 0.0142406 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0141955 |
| YBX3 | Y box binding protein 3 | 0.0139054 |
| RASAL2 | RAS protein activator like 2 | 0.0138987 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.318652 |
| MT2A | metallothionein 2A | -0.245774 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.182274 |
| FTL | ferritin, light polypeptide | -0.131716 |
| VIM | vimentin | -0.122269 |
| TMSB10 | thymosin beta 10 | -0.0845799 |
| POTEF | POTE ankyrin domain family, member F | -0.0843456 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0779206 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0577768 |
| CMIP | c-Maf inducing protein | -0.0544094 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0480437 |
| PFN1 | profilin 1 | -0.0473625 |
| ACTG1 | actin gamma 1 | -0.0468798 |
| RPLP0 | ribosomal protein, large, P0 | -0.0462156 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0438943 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.042421 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0401252 |
| STC1 | stanniocalcin 1 | -0.0386453 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0365189 |
| EGR1 | early growth response 1 | -0.0346044 |
| IGF2 | insulin-like growth factor 2 | -0.0345397 |
| PYGL | phosphorylase, glycogen, liver | -0.0343177 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0340032 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0338923 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0332733 |
| HMGA1 | high mobility group AT-hook 1 | -0.0329613 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0322949 |
| LDHA | lactate dehydrogenase A | -0.0321631 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0318935 |
| RPLP1 | ribosomal protein, large, P1 | -0.030232 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0286349 |
| PKM | pyruvate kinase, muscle | -0.0273 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0269542 |
| S100A6 | S100 calcium binding protein A6 | -0.0263037 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0262887 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0262426 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0261561 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0250739 |
| FLNB | filamin B, beta | -0.0243551 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0243461 |
| WWOX | WW domain containing oxidoreductase | -0.0241805 |
| ERBIN | erbb2 interacting protein | -0.0240621 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0234513 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0233539 |
| PARD3 | par-3 family cell polarity regulator | -0.0232098 |
| TPI1 | triosephosphate isomerase 1 | -0.023132 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0231189 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0225043 |
| KIF5B | kinesin family member 5B | -0.0221066 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0218714 |
| RPL19 | ribosomal protein L19 | -0.0216367 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.021353 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.021296 |
| IL6 | interleukin 6 | -0.0212187 |
| FMNL2 | formin-like 2 | -0.0203052 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0202446 |
| TAGLN2 | transgelin 2 | -0.0201185 |
| PLS3 | plastin 3 | -0.0197194 |
| ACTN1 | actinin, alpha 1 | -0.0195951 |
| S100A11 | S100 calcium binding protein A11 | -0.0193997 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | -0.0193312 |
| UBC | ubiquitin C | -0.0192082 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0191386 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0190492 |
| RPS5 | ribosomal protein S5 | -0.0189498 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0188943 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0187259 |
| EGFR | epidermal growth factor receptor | -0.0187169 |
| MCL1 | myeloid cell leukemia 1 | -0.0186932 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0184668 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0183015 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0181229 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.0180306 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0178963 |
| BICC1 | BicC family RNA binding protein 1 | -0.0176672 |
| FGB | fibrinogen beta chain | -0.0176635 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0175836 |
| LDHB | lactate dehydrogenase B | -0.0175527 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0174556 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0172998 |
| S100A10 | S100 calcium binding protein A10 | -0.0172619 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0169265 |
| PTMA | prothymosin, alpha | -0.0167357 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0165795 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0165608 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0164094 |
| RPS15 | ribosomal protein S15 | -0.016396 |
| RPS19 | ribosomal protein S19 | -0.0163594 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0163171 |
| TMEM87A | transmembrane protein 87A | -0.0162881 |
| RPS6 | ribosomal protein S6 | -0.0162183 |
| DDX24 | DEAD (Asp-Glu-Ala-Asp) box helicase 24 | -0.0161794 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | -0.0161556 |
| RPL8 | ribosomal protein L8 | -0.0160592 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0160172 |
| YY1 | YY1 transcription factor | -0.015975 |
| RAD51B | RAD51 paralog B | -0.0159214 |
| FGG | fibrinogen gamma chain | -0.0157253 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0156307 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0155607 |
