| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | crizotinib perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the crizotinib_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0900172 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0611504 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0558735 |
| PDE10A | phosphodiesterase 10A | 0.0541952 |
| RPS6 | ribosomal protein S6 | 0.0524274 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0522176 |
| SRPK2 | SRSF protein kinase 2 | 0.0520934 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0490968 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0460904 |
| RIGI | RNA sensor RIG-I | 0.0458373 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0448893 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0433599 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.041897 |
| RPL37A | ribosomal protein L37a | 0.0409892 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0401068 |
| ZNF292 | zinc finger protein 292 | 0.0389768 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0387103 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0371887 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0365124 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0361887 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0352803 |
| NEK7 | NIMA-related kinase 7 | 0.03474 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0346189 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | 0.0339382 |
| RPS19 | ribosomal protein S19 | 0.0328936 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0325709 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0320397 |
| KIF5B | kinesin family member 5B | 0.0318433 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | 0.0316092 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0311648 |
| RPS12 | ribosomal protein S12 | 0.0306039 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0292578 |
| HDAC4 | histone deacetylase 4 | 0.029144 |
| HELZ | helicase with zinc finger | 0.0291153 |
| AGO3 | argonaute RISC catalytic component 3 | 0.0286777 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.028661 |
| KLF6 | Kruppel-like factor 6 | 0.02826 |
| NCKAP1 | NCK-associated protein 1 | 0.0282011 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.0281561 |
| TFG | TRK-fused gene | 0.0273499 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0268537 |
| FNDC3A | fibronectin type III domain containing 3A | 0.026694 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0263114 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0259854 |
| RPLP1 | ribosomal protein, large, P1 | 0.0251991 |
| PTK2 | protein tyrosine kinase 2 | 0.0245993 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0243811 |
| IFRD1 | interferon-related developmental regulator 1 | 0.0243741 |
| CPNE8 | copine VIII | 0.0243477 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0242968 |
| TIAL1 | TIA1 cytotoxic granule-associated RNA binding protein-like 1 | 0.024012 |
| RPS25 | ribosomal protein S25 | 0.0239863 |
| PTMA | prothymosin, alpha | 0.0237634 |
| H2AC6 | H2A clustered histone 6 | 0.0233875 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0233667 |
| RNF149 | ring finger protein 149 | 0.0233399 |
| RPL8 | ribosomal protein L8 | 0.0230234 |
| COPB1 | coatomer protein complex, subunit beta 1 | 0.0229976 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0229732 |
| MXD1 | MAX dimerization protein 1 | 0.0229231 |
| FOXJ3 | forkhead box J3 | 0.0226478 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.022142 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0219456 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0215052 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0213028 |
| NPTN | neuroplastin | 0.0211492 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0210455 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0209075 |
| GOLGA4 | golgin A4 | 0.0208933 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | 0.0206266 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0204045 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | 0.0201959 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0199365 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0197934 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0197744 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | 0.0196461 |
| CLINT1 | clathrin interactor 1 | 0.0196358 |
| SEPTIN7 | septin 7 | 0.0195898 |
| MAGI3 | membrane associated guanylate kinase, WW and PDZ domain containing 3 | 0.0195818 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0195182 |
| CHD1L | chromodomain helicase DNA binding protein 1-like | 0.0194498 |
| ZNRF2 | zinc and ring finger 2, E3 ubiquitin protein ligase | 0.0192818 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0188696 |
| HBP1 | HMG-box transcription factor 1 | 0.0188353 |
| RPS5 | ribosomal protein S5 | 0.0187591 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.0186747 |
| RPS17 | ribosomal protein S17 | 0.0185014 |
| CDK17 | cyclin-dependent kinase 17 | 0.0184461 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0184381 |
| YBX1 | Y box binding protein 1 | 0.0184202 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0183645 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0183452 |
| DST | dystonin | 0.018254 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0180198 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | 0.0179777 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0179365 |
| LMAN1 | lectin, mannose-binding, 1 | 0.0179048 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | 0.0177396 |
| EFNA5 | ephrin-A5 | 0.0176193 |
| PGK1 | phosphoglycerate kinase 1 | 0.0175821 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | -0.0898572 |
| MYO1E | myosin IE | -0.0852276 |
| LAMC2 | laminin, gamma 2 | -0.0588141 |
| LAMB3 | laminin, beta 3 | -0.0583524 |
| TJP1 | tight junction protein 1 | -0.0549234 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0477422 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0467283 |
| PARD3 | par-3 family cell polarity regulator | -0.0463548 |
| MUC16 | mucin 16, cell surface associated | -0.0442558 |
| LMO7 | LIM domain 7 | -0.0430062 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0424738 |
| EGR1 | early growth response 1 | -0.042136 |
| ASPH | aspartate beta-hydroxylase | -0.040611 |
| KIF13B | kinesin family member 13B | -0.0393675 |
| STC1 | stanniocalcin 1 | -0.0387075 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0378679 |
| ATOSA | atos homolog A | -0.0376913 |
| LSAMP | limbic system-associated membrane protein | -0.0374646 |
| MED13 | mediator complex subunit 13 | -0.0369544 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | -0.0358862 |
| INTS6 | integrator complex subunit 6 | -0.0348419 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0342789 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0333131 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0332143 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0324424 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0318456 |
| NDRG1 | N-myc downstream regulated 1 | -0.0296138 |
| CUX1 | cut-like homeobox 1 | -0.0289435 |
| INHBA | inhibin, beta A | -0.0285166 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0283332 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0276808 |
| PATJ | PATJ crumbs cell polarity complex component | -0.027489 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.0271143 |
| SVIL | supervillin | -0.0270716 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.027008 |
| TGFA | transforming growth factor, alpha | -0.0266612 |
| SSH2 | slingshot protein phosphatase 2 | -0.0263637 |
| KYNU | kynureninase | -0.0262133 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0258964 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0250658 |
| ANKRD36C | ankyrin repeat domain 36C | -0.0249926 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0247473 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0240261 |
| ANXA2 | annexin A2 | -0.0239396 |
| VMP1 | vacuole membrane protein 1 | -0.0237132 |
| NCOA3 | nuclear receptor coactivator 3 | -0.0236754 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.0232531 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0230152 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0228928 |
| SPNS2 | spinster homolog 2 (Drosophila) | -0.022746 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0226443 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.0223146 |
| MORF4L2 | mortality factor 4 like 2 | -0.0221905 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.0220455 |
| SQSTM1 | sequestosome 1 | -0.0219664 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0219032 |
| TUFT1 | tuftelin 1 | -0.0218514 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0213689 |
| EGFR | epidermal growth factor receptor | -0.0212599 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0211903 |
| PRKCA | protein kinase C, alpha | -0.0211749 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0211618 |
| MT2A | metallothionein 2A | -0.0208977 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0208425 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0207713 |
| NCOR2 | nuclear receptor corepressor 2 | -0.0205692 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0205568 |
| SEPTIN9 | septin 9 | -0.0204783 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0201212 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0198747 |
| RRBP1 | ribosome binding protein 1 | -0.0196954 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0196872 |
| CANX | calnexin | -0.019536 |
| ARHGAP21 | Rho GTPase activating protein 21 | -0.0194989 |
| ACTG1 | actin gamma 1 | -0.0194982 |
| TNRC18 | trinucleotide repeat containing 18 | -0.0194078 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0193476 |
| ERBIN | erbb2 interacting protein | -0.0193153 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0190533 |
| RBM47 | RNA binding motif protein 47 | -0.0189111 |
| TPM4 | tropomyosin 4 | -0.0187963 |
| ABHD17C | abhydrolase domain containing 17C | -0.0187247 |
| UBC | ubiquitin C | -0.0187165 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0186557 |
| RREB1 | ras responsive element binding protein 1 | -0.018634 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | -0.0186316 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0186235 |
| FTL | ferritin, light polypeptide | -0.0186078 |
| MSN | moesin | -0.0186038 |
| CD44 | CD44 molecule (Indian blood group) | -0.0184181 |
| SHB | Src homology 2 domain containing adaptor protein B | -0.0183712 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0181147 |
| SRP54 | signal recognition particle 54kDa | -0.0180943 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0179274 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0178467 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.017517 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0174973 |
| PPP2R2C | protein phosphatase 2, regulatory subunit B, gamma | -0.017471 |
| SCEL | sciellin | -0.0174332 |
| DUSP5 | dual specificity phosphatase 5 | -0.0173486 |
