| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | crizotinib perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the crizotinib_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.133052 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0893489 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0856329 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0785844 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0768534 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.076528 |
| MCL1 | myeloid cell leukemia 1 | 0.0760474 |
| PCBP2 | poly(rC) binding protein 2 | 0.075412 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0740895 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0708089 |
| PTK2 | protein tyrosine kinase 2 | 0.070724 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0684177 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0660811 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0634068 |
| JMJD1C | jumonji domain containing 1C | 0.0625225 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0625048 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0620898 |
| TPM3 | tropomyosin 3 | 0.060015 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.058969 |
| FMNL2 | formin-like 2 | 0.0576841 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0554243 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0551079 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0540143 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0528842 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0522141 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.051229 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0511826 |
| COPA | coatomer protein complex, subunit alpha | 0.0503747 |
| RBM39 | RNA binding motif protein 39 | 0.0503011 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0496114 |
| TPM2 | tropomyosin 2 (beta) | 0.0490462 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0486307 |
| BRD2 | bromodomain containing 2 | 0.048581 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0485601 |
| OGA | O-GlcNAcase | 0.0459165 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.045812 |
| SETD5 | SET domain containing 5 | 0.045491 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0450509 |
| CCNL1 | cyclin L1 | 0.0450486 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0448935 |
| TXNRD1 | thioredoxin reductase 1 | 0.0445057 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0443191 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0443 |
| SNX9 | sorting nexin 9 | 0.0438224 |
| ACTN1 | actinin, alpha 1 | 0.0430655 |
| YBX3 | Y box binding protein 3 | 0.0429862 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0427834 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0419477 |
| RSF1 | remodeling and spacing factor 1 | 0.0413712 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0408201 |
| MED13L | mediator complex subunit 13-like | 0.0407714 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0407525 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0397905 |
| CUL3 | cullin 3 | 0.0395152 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0394232 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0391148 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0385702 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0378327 |
| USP34 | ubiquitin specific peptidase 34 | 0.0373924 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.036805 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0363868 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | 0.0363511 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0355995 |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 | 0.0353015 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0349773 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0342332 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0340469 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0338578 |
| FNIP1 | folliculin interacting protein 1 | 0.0333984 |
| PHF21A | PHD finger protein 21A | 0.033381 |
| NUP58 | nucleoporin 58 | 0.03324 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0328058 |
| PUM1 | pumilio RNA-binding family member 1 | 0.032786 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0327448 |
| GATAD2B | GATA zinc finger domain containing 2B | 0.0326114 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0322122 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.031842 |
| MMP12 | matrix metallopeptidase 12 | 0.0317919 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0317707 |
| MSN | moesin | 0.0317636 |
| ANO6 | anoctamin 6 | 0.031408 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0313348 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0312143 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | 0.0310427 |
| BRD4 | bromodomain containing 4 | 0.0307285 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0307097 |
| RBM25 | RNA binding motif protein 25 | 0.0305215 |
| NBAS | neuroblastoma amplified sequence | 0.0303839 |
| RHEB | Ras homolog enriched in brain | 0.0302771 |
| NLGN1 | neuroligin 1 | 0.0301774 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | 0.0301772 |
| TBK1 | TANK-binding kinase 1 | 0.029788 |
| HELZ | helicase with zinc finger | 0.0293001 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0292346 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0291429 |
| FOXJ3 | forkhead box J3 | 0.0288171 |
| NCKAP1 | NCK-associated protein 1 | 0.0287207 |
| ZNF644 | zinc finger protein 644 | 0.0286815 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0286547 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0286113 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.224404 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.126381 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.1242 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0766795 |
| PTMA | prothymosin, alpha | -0.0722241 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0707315 |
| RAD51B | RAD51 paralog B | -0.0651975 |
| GRAMD1B | GRAM domain containing 1B | -0.0651347 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0502888 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0501677 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0501013 |
| RPLP1 | ribosomal protein, large, P1 | -0.0488273 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0460519 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0438788 |
| PLSCR1 | phospholipid scramblase 1 | -0.0433859 |
| VDAC1 | voltage-dependent anion channel 1 | -0.042235 |
| RPL12 | ribosomal protein L12 | -0.0409602 |
| RPL26 | ribosomal protein L26 | -0.0394111 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.039342 |
| ACTG1 | actin gamma 1 | -0.0388827 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0380358 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0378496 |
| ZNF217 | zinc finger protein 217 | -0.0378172 |
| H1-0 | H1.0 linker histone | -0.0378012 |
| RPS8 | ribosomal protein S8 | -0.0377073 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0374712 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0372396 |
| RIGI | RNA sensor RIG-I | -0.035971 |
| ATP11A | ATPase, class VI, type 11A | -0.0342191 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.0336528 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0333911 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0330276 |
| RPLP0 | ribosomal protein, large, P0 | -0.0325817 |
| UBB | ubiquitin B | -0.0319616 |
| GNAS | GNAS complex locus | -0.0318985 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | -0.0318627 |
| PMP22 | peripheral myelin protein 22 | -0.0309888 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0308361 |
| RPL35A | ribosomal protein L35a | -0.0306701 |
| RACK1 | receptor for activated C kinase 1 | -0.0304802 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0304003 |
| PREPL | prolyl endopeptidase-like | -0.0303056 |
| RPS24 | ribosomal protein S24 | -0.028181 |
| ADAR | adenosine deaminase, RNA-specific | -0.0281725 |
| CAVIN1 | caveolae associated protein 1 | -0.028125 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.027482 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0268009 |
| RPS4X | ribosomal protein S4, X-linked | -0.0266869 |
| RPL38 | ribosomal protein L38 | -0.026593 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0264825 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0258558 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0258235 |
| RPS27A | ribosomal protein S27a | -0.0258183 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0256117 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0254971 |
| HELZ2 | helicase with zinc finger 2, transcriptional coactivator | -0.0252196 |
| RPL34 | ribosomal protein L34 | -0.0251159 |
| EIF2S1 | eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa | -0.0247878 |
| PAICS | phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase | -0.0244809 |
| BSG | basigin (Ok blood group) | -0.0244322 |
| RPS29 | ribosomal protein S29 | -0.0240398 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0240228 |
| STAT2 | signal transducer and activator of transcription 2, 113kDa | -0.0236741 |
| TRIM56 | tripartite motif containing 56 | -0.0236037 |
| TPI1 | triosephosphate isomerase 1 | -0.0232878 |
| RPS15 | ribosomal protein S15 | -0.0231511 |
| TUBB | tubulin, beta class I | -0.0228748 |
| GSTP1 | glutathione S-transferase pi 1 | -0.0228733 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0224345 |
| CCND2 | cyclin D2 | -0.0223409 |
| RPL32 | ribosomal protein L32 | -0.0221416 |
| CLSPN | claspin | -0.0219776 |
| AHNAK | AHNAK nucleoprotein | -0.0218712 |
| SRP72 | signal recognition particle 72kDa | -0.0218329 |
| RBL1 | retinoblastoma-like 1 | -0.0215287 |
| PARP9 | poly (ADP-ribose) polymerase family, member 9 | -0.0213719 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0211924 |
| RNF213 | ring finger protein 213 | -0.0211339 |
| PRKCE | protein kinase C, epsilon | -0.021108 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.020467 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0204619 |
| H1-3 | H1.3 linker histone, cluster member | -0.0204059 |
| HLA-E | major histocompatibility complex, class I, E | -0.0203344 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0202276 |
| KNTC1 | kinetochore associated 1 | -0.0200937 |
| CALU | calumenin | -0.0200839 |
| WWOX | WW domain containing oxidoreductase | -0.0199769 |
| CCND1 | cyclin D1 | -0.0199477 |
| BRCA1 | breast cancer 1, early onset | -0.0197924 |
| KLF6 | Kruppel-like factor 6 | -0.0197309 |
| FOXP1 | forkhead box P1 | -0.0196739 |
| WDHD1 | WD repeat and HMG-box DNA binding protein 1 | -0.0195983 |
| TGIF1 | TGFB-induced factor homeobox 1 | -0.0193374 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0193016 |
| ATAD2 | ATPase family, AAA domain containing 2 | -0.019283 |
| RRBP1 | ribosome binding protein 1 | -0.0192517 |
| CCDC47 | coiled-coil domain containing 47 | -0.0191875 |
| ZFR | zinc finger RNA binding protein | -0.0191785 |
| ANKRD36C | ankyrin repeat domain 36C | -0.019168 |
| DEK | DEK proto-oncogene | -0.019154 |
