crizotinib_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description crizotinib perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the crizotinib_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.143751
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.1291
CXCL8 chemokine (C-X-C motif) ligand 8 0.102571
EFNA5 ephrin-A5 0.10209
GDA guanine deaminase 0.0791286
ELL2 elongation factor, RNA polymerase II, 2 0.0741395
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0638561
TXNRD1 thioredoxin reductase 1 0.0596729
RTN4 reticulon 4 0.0583664
SPAG9 sperm associated antigen 9 0.0579161
AGFG1 ArfGAP with FG repeats 1 0.0562166
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.055957
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0530841
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0516814
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0500079
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0491654
NEK7 NIMA-related kinase 7 0.047255
ERRFI1 ERBB receptor feedback inhibitor 1 0.0472217
TFPI2 tissue factor pathway inhibitor 2 0.0415208
OGA O-GlcNAcase 0.0412973
TRIO trio Rho guanine nucleotide exchange factor 0.0409817
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0404318
JMJD1C jumonji domain containing 1C 0.0391305
RBM39 RNA binding motif protein 39 0.0387695
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 0.0378457
CD109 CD109 molecule 0.0369654
USP3 ubiquitin specific peptidase 3 0.0359747
BIRC6 baculoviral IAP repeat containing 6 0.035551
RICTOR RPTOR independent companion of MTOR, complex 2 0.0349041
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0347639
EZR ezrin 0.0347471
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0344217
BZW1 basic leucine zipper and W2 domains 1 0.0340764
PGK1 phosphoglycerate kinase 1 0.0338244
BMERB1 bMERB domain containing 1 0.0337382
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0332889
ZEB2 zinc finger E-box binding homeobox 2 0.032235
KMT2E lysine (K)-specific methyltransferase 2E 0.0322025
AKAP13 A kinase (PRKA) anchor protein 13 0.0316087
KMT2C lysine (K)-specific methyltransferase 2C 0.0308778
DOCK4 dedicator of cytokinesis 4 0.0306319
NUP58 nucleoporin 58 0.0302595
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0301845
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0300831
ITPRID2 ITPR interacting domain containing 2 0.0299
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0294457
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0293919
SNX9 sorting nexin 9 0.0292272
WDR43 WD repeat domain 43 0.0289257
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0287331
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0287329
NRCAM neuronal cell adhesion molecule 0.0286447
FAM13A family with sequence similarity 13, member A 0.0284846
KDM6A lysine (K)-specific demethylase 6A 0.0284033
PTK2 protein tyrosine kinase 2 0.0283185
SOD2 superoxide dismutase 2, mitochondrial 0.0282126
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0278497
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0275931
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0274344
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0268271
DGKD diacylglycerol kinase, delta 130kDa 0.0266107
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0265951
NPAS2 neuronal PAS domain protein 2 0.0260008
ESYT2 extended synaptotagmin-like protein 2 0.0259817
ZNF292 zinc finger protein 292 0.0259431
ANKRD28 ankyrin repeat domain 28 0.0258155
FN1 fibronectin 1 0.0257817
MXI1 MAX interactor 1, dimerization protein 0.0257446
AFF4 AF4/FMR2 family, member 4 0.0257008
ATP13A3 ATPase type 13A3 0.0256016
TSC22D2 TSC22 domain family, member 2 0.0255577
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0254238
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0252986
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0252941
B2M beta-2-microglobulin 0.025264
FTH1 ferritin, heavy polypeptide 1 0.0252293
WDR45B WD repeat domain 45B 0.0251227
BRWD3 bromodomain and WD repeat domain containing 3 0.0250858
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0243256
ZFAND3 zinc finger, AN1-type domain 3 0.0237438
MARCHF6 membrane associated ring-CH-type finger 6 0.0237289
NCAM1 neural cell adhesion molecule 1 0.0237224
AVL9 AVL9 homolog (S. cerevisiase) 0.0227041
TMSB4X thymosin beta 4, X-linked 0.0225796
KDM3A lysine (K)-specific demethylase 3A 0.0221304
WAC WW domain containing adaptor with coiled-coil 0.0220697
UGCG UDP-glucose ceramide glucosyltransferase 0.0220426
ANKRD11 ankyrin repeat domain 11 0.0219656
NCKAP1 NCK-associated protein 1 0.0218281
SLK STE20-like kinase 0.0216601
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0216594
FNDC3A fibronectin type III domain containing 3A 0.0215576
ANXA5 annexin A5 0.0214971
KPNB1 karyopherin (importin) beta 1 0.0214343
NRG1 neuregulin 1 0.021419
CDC73 cell division cycle 73 0.0213992
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0211743
GOLGA4 golgin A4 0.0208912
RNF145 ring finger protein 145 0.0208798
CDK17 cyclin-dependent kinase 17 0.0207566

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.1549
PDE10A phosphodiesterase 10A -0.132986
PDE4D phosphodiesterase 4D, cAMP-specific -0.113366
TMSB10 thymosin beta 10 -0.113044
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0963639
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0894397
COL5A2 collagen, type V, alpha 2 -0.0807427
PTMA prothymosin, alpha -0.0796023
UBC ubiquitin C -0.0758284
RPS27A ribosomal protein S27a -0.0747118
VIM vimentin -0.0651722
RPL23 ribosomal protein L23 -0.0621142
VCL vinculin -0.0614827
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0614335
PRKN parkin RBR E3 ubiquitin protein ligase -0.0585273
DST dystonin -0.0504948
FTL ferritin, light polypeptide -0.0491432
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0487172
RPS8 ribosomal protein S8 -0.0471208
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0470069
RAD51B RAD51 paralog B -0.0453362
EEF2 eukaryotic translation elongation factor 2 -0.0445892
INTS6 integrator complex subunit 6 -0.0442958
PM20D1 peptidase M20 domain containing 1 -0.0440838
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0431707
LSAMP limbic system-associated membrane protein -0.043078
RPL37A ribosomal protein L37a -0.0429432
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0424252
POTEF POTE ankyrin domain family, member F -0.0421758
PCBP2 poly(rC) binding protein 2 -0.0419532
PKM pyruvate kinase, muscle -0.0417517
MCL1 myeloid cell leukemia 1 -0.0407922
ENO1 enolase 1, (alpha) -0.0402167
CTIF CBP80/20-dependent translation initiation factor -0.0401411
PRELID2 PRELI domain containing 2 -0.039525
RPL12 ribosomal protein L12 -0.0391229
RPS3 ribosomal protein S3 -0.039098
MAML3 mastermind-like 3 (Drosophila) -0.0388976
RPS12 ribosomal protein S12 -0.0388887
MT2A metallothionein 2A -0.0377854
RPL31 ribosomal protein L31 -0.0371966
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0370807
P3H2 prolyl 3-hydroxylase 2 -0.0369828
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0365284
ASPH aspartate beta-hydroxylase -0.0349161
ACTG1 actin gamma 1 -0.0344633
CADM2 cell adhesion molecule 2 -0.0343745
PDIA4 protein disulfide isomerase family A, member 4 -0.0341195
AHNAK AHNAK nucleoprotein -0.033125
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0322853
SMOC1 SPARC related modular calcium binding 1 -0.0320578
FLNA filamin A, alpha -0.0318703
RPL26 ribosomal protein L26 -0.0312204
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0311629
LOC112694756 uncharaterized LOC112694756 -0.0288816
GPC6 glypican 6 -0.0286677
RPS19 ribosomal protein S19 -0.0282391
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0281153
BASP1 brain abundant, membrane attached signal protein 1 -0.0279683
PALLD palladin, cytoskeletal associated protein -0.0277402
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0274683
CALR calreticulin -0.0272749
RPLP2 ribosomal protein, large, P2 -0.0272007
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0271793
LAMA5 laminin, alpha 5 -0.0265567
LIMCH1 LIM and calponin homology domains 1 -0.0264101
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0262774
RPL9 ribosomal protein L9 -0.0261642
RPL19 ribosomal protein L19 -0.0259717
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.025884
PCDH15 protocadherin-related 15 -0.025685
NCOR2 nuclear receptor corepressor 2 -0.0256456
HDAC4 histone deacetylase 4 -0.025391
RPLP1 ribosomal protein, large, P1 -0.0253512
RPS29 ribosomal protein S29 -0.0253032
RPS4X ribosomal protein S4, X-linked -0.0245126
PRDX1 peroxiredoxin 1 -0.0243899
SET SET nuclear proto-oncogene -0.0240371
AUTS2 autism susceptibility candidate 2 -0.0240147
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0233998
RPS23 ribosomal protein S23 -0.0232519
ADGRD1 adhesion G protein-coupled receptor D1 -0.0230566
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.022916
RPS6 ribosomal protein S6 -0.0228648
RPS27 ribosomal protein S27 -0.0224331
PDLIM5 PDZ and LIM domain 5 -0.022346
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0220381
NAP1L1 nucleosome assembly protein 1-like 1 -0.0219398
AGTPBP1 ATP/GTP binding protein 1 -0.0219198
ANTXR1 anthrax toxin receptor 1 -0.0216006
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0215216
PTPRM protein tyrosine phosphatase, receptor type, M -0.0212276
PFN1 profilin 1 -0.021096
RPL28 ribosomal protein L28 -0.0210663
ZNF638 zinc finger protein 638 -0.0210257
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0208315
PDE7B phosphodiesterase 7B -0.020806
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0207274
VMP1 vacuole membrane protein 1 -0.0205591
SMYD3 SET and MYND domain containing 3 -0.0205428