crizotinib_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description crizotinib perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

104 genes differentially expressed following the crizotinib_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GOLGA4 golgin A4 0.175476
TRIO trio Rho guanine nucleotide exchange factor 0.166236
AKAP12 A kinase (PRKA) anchor protein 12 0.162024
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.147831
SBF2 SET binding factor 2 0.142696
OGA O-GlcNAcase 0.136297
PRRC2C proline-rich coiled-coil 2C 0.127749
FMNL2 formin-like 2 0.121331
ENO1 enolase 1, (alpha) 0.120146
FNDC3B fibronectin type III domain containing 3B 0.117101
RPS8 ribosomal protein S8 0.113877
DST dystonin 0.106466
TMSB10 thymosin beta 10 0.0989398
TTC3 tetratricopeptide repeat domain 3 0.0965076
DLG1 discs, large homolog 1 (Drosophila) 0.0958407
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0908953
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0847172
TPT1 tumor protein, translationally-controlled 1 0.0760018
HELZ helicase with zinc finger 0.0748913
EXT1 exostosin glycosyltransferase 1 0.0746898
PGK1 phosphoglycerate kinase 1 0.0744568
NKTR natural killer cell triggering receptor 0.072462
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0712503
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0680128
MACF1 microtubule-actin crosslinking factor 1 0.0667356
DSCAM Down syndrome cell adhesion molecule 0.0640739
FXR1 fragile X mental retardation, autosomal homolog 1 0.062341
RPLP1 ribosomal protein, large, P1 0.0622567
WAC WW domain containing adaptor with coiled-coil 0.0620709
ERRFI1 ERBB receptor feedback inhibitor 1 0.0601649
BBX bobby sox homolog (Drosophila) 0.059579
RUNX1 runt-related transcription factor 1 0.0566172
GLS2 glutaminase 2 (liver, mitochondrial) 0.0557648
TBC1D22A TBC1 domain family, member 22A 0.0489852
NF1 neurofibromin 1 0.0487493
VCL vinculin 0.0485029
RPS3 ribosomal protein S3 0.0463278
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0441945
ZNF292 zinc finger protein 292 0.0422526
MED13 mediator complex subunit 13 0.042106
ARHGAP32 Rho GTPase activating protein 32 0.0414403
EZR ezrin 0.0410349
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0378669
RPS6 ribosomal protein S6 0.0349238
ASPH aspartate beta-hydroxylase 0.0289559
GCLC glutamate-cysteine ligase, catalytic subunit 0.0270887
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0247222
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0245945
SPAG9 sperm associated antigen 9 0.0206326
ATXN1 ataxin 1 0.0146973
ELL2 elongation factor, RNA polymerase II, 2 0.0109256
EIF1 eukaryotic translation initiation factor 1 0.00814327
RAD51B RAD51 paralog B 0.00727333
NAMPT nicotinamide phosphoribosyltransferase 0.00373682
RPL23 ribosomal protein L23 0.00345159
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.00227955
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 3.02684E-4

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.204863
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.173977
FNDC3A fibronectin type III domain containing 3A -0.166469
PDE10A phosphodiesterase 10A -0.15657
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.15109
PTMA prothymosin, alpha -0.147716
PSD3 pleckstrin and Sec7 domain containing 3 -0.146878
NKD1 naked cuticle homolog 1 (Drosophila) -0.135669
RORA RAR-related orphan receptor A -0.135388
UBC ubiquitin C -0.123568
FN1 fibronectin 1 -0.110889
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.108815
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.10272
LAMA4 laminin, alpha 4 -0.100703
CCNI cyclin I -0.0939122
GPC6 glypican 6 -0.0933985
ACTN4 actinin, alpha 4 -0.083406
EGFR epidermal growth factor receptor -0.0808784
PTPRM protein tyrosine phosphatase, receptor type, M -0.0807314
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0783249
EFNA5 ephrin-A5 -0.0783183
ANXA2 annexin A2 -0.0783037
RLF rearranged L-myc fusion -0.0736785
NUP58 nucleoporin 58 -0.0717539
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0664893
SETD5 SET domain containing 5 -0.0612232
CDH13 cadherin 13 -0.057666
NHSL1 NHS-like 1 -0.0541929
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0503112
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0470387
LDHA lactate dehydrogenase A -0.0468045
RTN4 reticulon 4 -0.0414644
MAML2 mastermind-like 2 (Drosophila) -0.0379785
NDRG1 N-myc downstream regulated 1 -0.0358981
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0357732
SMYD3 SET and MYND domain containing 3 -0.0327579
RPS27A ribosomal protein S27a -0.0312263
MYO1E myosin IE -0.0294322
VIM vimentin -0.0233997
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0223928
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0184332
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0153962
PARD3 par-3 family cell polarity regulator -0.0126117
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0119754
PRKCA protein kinase C, alpha -0.00506252
PKM pyruvate kinase, muscle -0.00425631
ZBTB20 zinc finger and BTB domain containing 20 -0.00236138