| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | crizotinib perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the crizotinib_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.120721 |
| TMSB4X | thymosin beta 4, X-linked | 0.0946699 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0888169 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | 0.0841651 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0704832 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0620198 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0526888 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0481849 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | 0.0477284 |
| B2M | beta-2-microglobulin | 0.0458962 |
| ITGAV | integrin, alpha V | 0.044836 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0443676 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | 0.0442574 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0441381 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0428356 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0427735 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0410317 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0406291 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0402888 |
| MKI67 | marker of proliferation Ki-67 | 0.0389766 |
| COL3A1 | collagen, type III, alpha 1 | 0.0389534 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | 0.0388419 |
| RHEB | Ras homolog enriched in brain | 0.0382745 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0369154 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0364457 |
| TJP1 | tight junction protein 1 | 0.0359773 |
| ACTN4 | actinin, alpha 4 | 0.0359674 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0349205 |
| MATR3 | matrin 3 | 0.0340189 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0339907 |
| RYBP | RING1 and YY1 binding protein | 0.0331497 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0326561 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0322137 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0315031 |
| PDGFC | platelet derived growth factor C | 0.0313904 |
| CDK6 | cyclin-dependent kinase 6 | 0.0308609 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0308041 |
| SUCO | SUN domain containing ossification factor | 0.0307604 |
| NFIA | nuclear factor I/A | 0.0305306 |
| THBS1 | thrombospondin 1 | 0.0304928 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0302018 |
| ETV1 | ets variant 1 | 0.0300659 |
| TPR | translocated promoter region, nuclear basket protein | 0.0300109 |
| KIF5B | kinesin family member 5B | 0.0298269 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0290811 |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | 0.0290119 |
| APP | amyloid beta (A4) precursor protein | 0.028984 |
| MBIP | MAP3K12 binding inhibitory protein 1 | 0.0289831 |
| TPX2 | TPX2, microtubule-associated | 0.028469 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0278963 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | 0.0278059 |
| TPM3 | tropomyosin 3 | 0.0277743 |
| OSBPL9 | oxysterol binding protein-like 9 | 0.0274837 |
| FUS | FUS RNA binding protein | 0.0273132 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0268307 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0267113 |
| ELOVL5 | ELOVL fatty acid elongase 5 | 0.026654 |
| ANXA1 | annexin A1 | 0.026498 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0262365 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0262247 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.02582 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0258012 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0256781 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.0256699 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0255991 |
| LBR | lamin B receptor | 0.0255173 |
| ANLN | anillin, actin binding protein | 0.0254347 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0254081 |
| CCNY | cyclin Y | 0.0249122 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0247589 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0246665 |
| VMP1 | vacuole membrane protein 1 | 0.0246525 |
| RHOA | ras homolog family member A | 0.0245889 |
| COL5A2 | collagen, type V, alpha 2 | 0.0244923 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0244529 |
| OLA1 | Obg-like ATPase 1 | 0.0244116 |
| ZNF292 | zinc finger protein 292 | 0.02441 |
| OGA | O-GlcNAcase | 0.0243732 |
| JMJD1C | jumonji domain containing 1C | 0.0240433 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0239857 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0238694 |
| XPO1 | exportin 1 | 0.023683 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.023647 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0236141 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0235469 |
| NEK7 | NIMA-related kinase 7 | 0.0234951 |
| ANXA5 | annexin A5 | 0.0232596 |
| SLC16A1 | solute carrier family 16 (monocarboxylate transporter), member 1 | 0.0229773 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0229657 |
| PHF21A | PHD finger protein 21A | 0.0226762 |
| SBNO1 | strawberry notch homolog 1 (Drosophila) | 0.0226736 |
| CCNA2 | cyclin A2 | 0.022612 |
| SNX4 | sorting nexin 4 | 0.0226 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.022591 |
| IPO11 | importin 11 | 0.0225625 |
| ABI2 | abl-interactor 2 | 0.0225223 |
| USP14 | ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) | 0.0224264 |
| FAR1 | fatty acyl CoA reductase 1 | 0.0224053 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0223391 |
| PLEKHB2 | pleckstrin homology domain containing, family B (evectins) member 2 | 0.0221824 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.139691 |
| GPC3 | glypican 3 | -0.111999 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.104905 |
| COL11A1 | collagen, type XI, alpha 1 | -0.0914531 |
| PTMA | prothymosin, alpha | -0.084876 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | -0.0838117 |
| PCDH9 | protocadherin 9 | -0.0787499 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.0768212 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0582946 |
| PFN1 | profilin 1 | -0.0557944 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0540835 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | -0.0538559 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | -0.0535595 |
| PGAP1 | post-GPI attachment to proteins 1 | -0.0530062 |
| MPG | N-methylpurine-DNA glycosylase | -0.0499052 |
| NTM | neurotrimin | -0.0470765 |
| TMSB10 | thymosin beta 10 | -0.0462619 |
| ANKRD33B | ankyrin repeat domain 33B | -0.0460085 |
| RPS16 | ribosomal protein S16 | -0.0456979 |
| RAD51B | RAD51 paralog B | -0.043749 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0419456 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0404979 |
| CADM2 | cell adhesion molecule 2 | -0.0402589 |
| PRR16 | proline rich 16 | -0.0400713 |
| NPAS3 | neuronal PAS domain protein 3 | -0.0392683 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.038194 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | -0.0381025 |
| GALNTL6 | polypeptide N-acetylgalactosaminyltransferase-like 6 | -0.0379326 |
| HDAC9 | histone deacetylase 9 | -0.036839 |
| LATS2 | large tumor suppressor kinase 2 | -0.035506 |
| GNAS | GNAS complex locus | -0.0339486 |
| MYO10 | myosin X | -0.0324918 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0323808 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0321901 |
| BMPR1A | bone morphogenetic protein receptor, type IA | -0.0318722 |
| LHFPL6 | LHFPL tetraspan subfamily member 6 | -0.0315651 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0313866 |
| WWC2 | WW and C2 domain containing 2 | -0.0310757 |
| NRG1 | neuregulin 1 | -0.0307971 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0298324 |
| PLEKHG1 | pleckstrin homology domain containing, family G (with RhoGef domain) member 1 | -0.0286167 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0285187 |
| MRPS30 | mitochondrial ribosomal protein S30 | -0.0283769 |
| RPL23 | ribosomal protein L23 | -0.0274307 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0261669 |
| PHIP | pleckstrin homology domain interacting protein | -0.0260158 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0259637 |
| SMC3 | structural maintenance of chromosomes 3 | -0.0259126 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.0256827 |
| JUN | jun proto-oncogene | -0.0256819 |
| CRISPLD1 | cysteine-rich secretory protein LCCL domain containing 1 | -0.0252885 |
| PRELID2 | PRELI domain containing 2 | -0.0252746 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0251052 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0250506 |
| TENM2 | teneurin transmembrane protein 2 | -0.0246152 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.0245457 |
| PEG10 | paternally expressed 10 | -0.0245113 |
| RPS3 | ribosomal protein S3 | -0.0244432 |
| POTEF | POTE ankyrin domain family, member F | -0.0235149 |
| GPC4 | glypican 4 | -0.0234933 |
| LYST | lysosomal trafficking regulator | -0.0234775 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0231358 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0227735 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.022718 |
| FRY | furry homolog (Drosophila) | -0.0226292 |
| NEBL | nebulette | -0.0225644 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.0224701 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | -0.0224356 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0224174 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0223249 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | -0.022214 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0220998 |
| HMGA1 | high mobility group AT-hook 1 | -0.0217261 |
| TCEAL9 | transcription elongation factor A like 9 | -0.0216792 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0215045 |
| MECP2 | methyl CpG binding protein 2 | -0.0214205 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | -0.0213385 |
| FN1 | fibronectin 1 | -0.0212192 |
| TUBA1A | tubulin, alpha 1a | -0.0211216 |
| NR6A1 | nuclear receptor subfamily 6, group A, member 1 | -0.0210531 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0210414 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0209738 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0205973 |
| RPLP0 | ribosomal protein, large, P0 | -0.0205221 |
| RASAL2 | RAS protein activator like 2 | -0.0204538 |
| RPL35A | ribosomal protein L35a | -0.0203206 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.0202635 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.0201747 |
| SCAF11 | SR-related CTD-associated factor 11 | -0.0200696 |
| NELL2 | NEL-like 2 (chicken) | -0.0199092 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0197426 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0196461 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0194077 |
| MAP4 | microtubule-associated protein 4 | -0.0193759 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0193379 |
| ID3 | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein | -0.0193375 |
| SHROOM3 | shroom family member 3 | -0.0193253 |
| CDH19 | cadherin 19, type 2 | -0.018711 |
| TRAPPC9 | trafficking protein particle complex 9 | -0.0186974 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0184405 |
