crizotinib_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description crizotinib perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the crizotinib_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TMSB4X thymosin beta 4, X-linked 0.107025
SSBP2 single-stranded DNA binding protein 2 0.104366
PDE4D phosphodiesterase 4D, cAMP-specific 0.0838835
ECT2 epithelial cell transforming 2 0.0722961
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0692067
ADAM10 ADAM metallopeptidase domain 10 0.0687007
EML4 echinoderm microtubule associated protein like 4 0.0678314
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0665308
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0656202
PDE4B phosphodiesterase 4B, cAMP-specific 0.0612528
VCL vinculin 0.0600889
ZFAND3 zinc finger, AN1-type domain 3 0.0570165
RBM39 RNA binding motif protein 39 0.0559256
KDM3A lysine (K)-specific demethylase 3A 0.0549934
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0534134
SOX6 SRY (sex determining region Y)-box 6 0.0514062
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0506928
PDGFC platelet derived growth factor C 0.0475525
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0472688
LPP LIM domain containing preferred translocation partner in lipoma 0.0465472
QKI QKI, KH domain containing, RNA binding 0.0464656
HDAC9 histone deacetylase 9 0.0459472
NAMPT nicotinamide phosphoribosyltransferase 0.0458322
ZEB1 zinc finger E-box binding homeobox 1 0.0452752
PTK2 protein tyrosine kinase 2 0.0434719
ZNF292 zinc finger protein 292 0.0431319
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0428877
PUM2 pumilio RNA-binding family member 2 0.0427174
EXT1 exostosin glycosyltransferase 1 0.0419856
EZR ezrin 0.0398872
ANKRD11 ankyrin repeat domain 11 0.0390033
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0378381
KMT2E lysine (K)-specific methyltransferase 2E 0.0366803
PICALM phosphatidylinositol binding clathrin assembly protein 0.0357822
RNF145 ring finger protein 145 0.0357503
MATR3 matrin 3 0.0356863
ZMYM2 zinc finger, MYM-type 2 0.0353522
NF1 neurofibromin 1 0.0351394
NCKAP1 NCK-associated protein 1 0.0348716
WAC WW domain containing adaptor with coiled-coil 0.0346089
NBAS neuroblastoma amplified sequence 0.0342866
EIF4A2 eukaryotic translation initiation factor 4A2 0.0339656
TJP1 tight junction protein 1 0.0332864
CDC73 cell division cycle 73 0.0330034
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0329768
DSCAM Down syndrome cell adhesion molecule 0.0323385
RTN4 reticulon 4 0.0321178
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0319965
ZNF644 zinc finger protein 644 0.0311943
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0308719
CPED1 cadherin-like and PC-esterase domain containing 1 0.0307805
CAMTA1 calmodulin binding transcription activator 1 0.0303357
NBEA neurobeachin 0.0302932
APP amyloid beta (A4) precursor protein 0.0302623
OGA O-GlcNAcase 0.0300514
ELOVL5 ELOVL fatty acid elongase 5 0.0283442
AHNAK AHNAK nucleoprotein 0.0283437
TFG TRK-fused gene 0.0282221
RLF rearranged L-myc fusion 0.0281379
ZNF608 zinc finger protein 608 0.0277487
EFNA5 ephrin-A5 0.0276699
BIRC6 baculoviral IAP repeat containing 6 0.0275514
SLMAP sarcolemma associated protein 0.027271
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0267516
NFIA nuclear factor I/A 0.0264234
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0261658
TOP2B topoisomerase (DNA) II beta 180kDa 0.0260764
PRELID2 PRELI domain containing 2 0.026024
DLG1 discs, large homolog 1 (Drosophila) 0.0259637
GSK3B glycogen synthase kinase 3 beta 0.02595
JMJD1C jumonji domain containing 1C 0.0256483
NCOR1 nuclear receptor corepressor 1 0.025537
SLC38A2 solute carrier family 38, member 2 0.0254347
SPAG9 sperm associated antigen 9 0.0253312
MARCHF6 membrane associated ring-CH-type finger 6 0.0251143
ASXL1 additional sex combs like transcriptional regulator 1 0.0250919
FBXO11 F-box protein 11 0.0250654
RHEB Ras homolog enriched in brain 0.0250134
TRA2A transformer 2 alpha homolog (Drosophila) 0.0248864
PTBP2 polypyrimidine tract binding protein 2 0.0248107
SRPK2 SRSF protein kinase 2 0.0247485
FOXJ3 forkhead box J3 0.0246343
NCOA3 nuclear receptor coactivator 3 0.0244315
TNRC6B trinucleotide repeat containing 6B 0.0244021
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0242644
MSI2 musashi RNA-binding protein 2 0.024227
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0242139
ADAM9 ADAM metallopeptidase domain 9 0.0240239
PRPF38B pre-mRNA processing factor 38B 0.0236572
UBA6 ubiquitin-like modifier activating enzyme 6 0.0236399
RAB1A RAB1A, member RAS oncogene family 0.023527
USP3 ubiquitin specific peptidase 3 0.0233036
MBNL1 muscleblind-like splicing regulator 1 0.0231579
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0231429
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0228999
TGFBR3 transforming growth factor, beta receptor III 0.0228801
FNDC3B fibronectin type III domain containing 3B 0.0227919
FLNB filamin B, beta 0.0227407
FXR1 fragile X mental retardation, autosomal homolog 1 0.0226894
ANKRD17 ankyrin repeat domain 17 0.0225479

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.200819
PTMA prothymosin, alpha -0.191969
RPS6 ribosomal protein S6 -0.0945486
RPS8 ribosomal protein S8 -0.0863914
RPL35A ribosomal protein L35a -0.0736489
RPS19 ribosomal protein S19 -0.0681704
RPL37A ribosomal protein L37a -0.0603721
RPS3 ribosomal protein S3 -0.0600331
RPL31 ribosomal protein L31 -0.0594155
RPL34 ribosomal protein L34 -0.0589557
RPL23 ribosomal protein L23 -0.0569476
TPT1 tumor protein, translationally-controlled 1 -0.0562902
RPL12 ribosomal protein L12 -0.0547336
RPLP2 ribosomal protein, large, P2 -0.0527824
RPL19 ribosomal protein L19 -0.0518189
RPS12 ribosomal protein S12 -0.0508827
RPS23 ribosomal protein S23 -0.0503511
RPL26 ribosomal protein L26 -0.0500057
RPL36 ribosomal protein L36 -0.0466511
RPS29 ribosomal protein S29 -0.045656
RPS13 ribosomal protein S13 -0.045627
ACTG1 actin gamma 1 -0.0454819
RPL9 ribosomal protein L9 -0.0452825
RPLP1 ribosomal protein, large, P1 -0.0445525
TMSB10 thymosin beta 10 -0.0409763
FTL ferritin, light polypeptide -0.0394201
PRDX2 peroxiredoxin 2 -0.039332
PFN1 profilin 1 -0.0392659
RPS25 ribosomal protein S25 -0.0383597
RPS27A ribosomal protein S27a -0.0355033
S100A9 S100 calcium binding protein A9 -0.03437
RPS16 ribosomal protein S16 -0.0340656
ENO2 enolase 2 (gamma, neuronal) -0.0336767
RPL30 ribosomal protein L30 -0.0335697
RPS27 ribosomal protein S27 -0.0334798
RPL8 ribosomal protein L8 -0.0331355
RPL32 ribosomal protein L32 -0.0312908
RACK1 receptor for activated C kinase 1 -0.0293846
RPL7A ribosomal protein L7a -0.0288217
HSPB1 heat shock 27kDa protein 1 -0.0286028
RPS14 ribosomal protein S14 -0.0283815
RPL28 ribosomal protein L28 -0.0282922
RPL5 ribosomal protein L5 -0.0282157
POTEF POTE ankyrin domain family, member F -0.0278492
RPS11 ribosomal protein S11 -0.0275062
RPL13A ribosomal protein L13a -0.0273516
PKM pyruvate kinase, muscle -0.0271833
RPS21 ribosomal protein S21 -0.0269286
RPLP0 ribosomal protein, large, P0 -0.0259866
LOC112694756 uncharaterized LOC112694756 -0.0258726
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0249646
EIF1 eukaryotic translation initiation factor 1 -0.0246788
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0244227
S100A6 S100 calcium binding protein A6 -0.023942
RPL11 ribosomal protein L11 -0.0235542
RPL18 ribosomal protein L18 -0.0233559
RPS17 ribosomal protein S17 -0.0232333
RPL37 ribosomal protein L37 -0.0229029
RPL27 ribosomal protein L27 -0.0225623
RPS10 ribosomal protein S10 -0.0219814
HMGA1 high mobility group AT-hook 1 -0.0216782
RPL36A ribosomal protein L36a -0.0213518
RPS2 ribosomal protein S2 -0.0212562
ARL4C ADP-ribosylation factor-like 4C -0.020735
EEF1G eukaryotic translation elongation factor 1 gamma -0.0203519
RPS4X ribosomal protein S4, X-linked -0.0202875
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0200388
RPL27A ribosomal protein L27a -0.0197564
RPS24 ribosomal protein S24 -0.019531
IFI6 interferon, alpha-inducible protein 6 -0.0190576
RPL10A ribosomal protein L10a -0.0186929
RPS5 ribosomal protein S5 -0.0186916
NACA nascent polypeptide-associated complex alpha subunit -0.0183619
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0182938
LOC102724023 ES1 protein homolog, mitochondrial -0.0182605
IFITM3 interferon induced transmembrane protein 3 -0.0173958
MT2A metallothionein 2A -0.0170805
MYL12B myosin, light chain 12B, regulatory -0.016828
S100A10 S100 calcium binding protein A10 -0.0167051
LDHB lactate dehydrogenase B -0.016618
RPL38 ribosomal protein L38 -0.0166029
S100A4 S100 calcium binding protein A4 -0.0165857
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0163735
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0161152
ASTN2 astrotactin 2 -0.015673
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0153171
RPS15 ribosomal protein S15 -0.0152042
UBXN4 UBX domain protein 4 -0.0149692
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0146838
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0143793
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa -0.0143351
VIM vimentin -0.0142074
ATF4 activating transcription factor 4 -0.0141491
RPL35 ribosomal protein L35 -0.0140416
SERF2 small EDRK-rich factor 2 -0.0139707
TPI1 triosephosphate isomerase 1 -0.0139127
HLA-B major histocompatibility complex, class I, B -0.0138027
DDX18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 -0.0136148
RPL15 ribosomal protein L15 -0.013174
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.013106