crizotinib_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description crizotinib perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the crizotinib_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.131165
ELL2 elongation factor, RNA polymerase II, 2 0.0774738
ERRFI1 ERBB receptor feedback inhibitor 1 0.0394172
SOD2 superoxide dismutase 2, mitochondrial 0.0391219
FAM13A family with sequence similarity 13, member A 0.0375801
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0361892
RTN4 reticulon 4 0.0327003
DSCAM Down syndrome cell adhesion molecule 0.0323926
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0322386
TRIO trio Rho guanine nucleotide exchange factor 0.031929
RAB8B RAB8B, member RAS oncogene family 0.0317366
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.031446
ZNF292 zinc finger protein 292 0.0303421
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0286951
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0284985
MEF2A myocyte enhancer factor 2A 0.0282511
FNDC3B fibronectin type III domain containing 3B 0.0273774
RLF rearranged L-myc fusion 0.0273685
MED13L mediator complex subunit 13-like 0.0261449
KDM6A lysine (K)-specific demethylase 6A 0.0258691
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0256159
MATR3 matrin 3 0.0252901
TRA2A transformer 2 alpha homolog (Drosophila) 0.0249146
ACSL3 acyl-CoA synthetase long-chain family member 3 0.024497
ARRDC3 arrestin domain containing 3 0.0240218
SMAD3 SMAD family member 3 0.0234663
AVL9 AVL9 homolog (S. cerevisiase) 0.0226602
ATP13A3 ATPase type 13A3 0.022647
RICTOR RPTOR independent companion of MTOR, complex 2 0.0224599
ANTXR2 anthrax toxin receptor 2 0.0223953
AFF4 AF4/FMR2 family, member 4 0.0220167
HELZ helicase with zinc finger 0.0210175
NPEPPS aminopeptidase puromycin sensitive 0.0209431
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0208811
WTAP Wilms tumor 1 associated protein 0.0206516
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0204838
TMEM123 transmembrane protein 123 0.0203954
USP9X ubiquitin specific peptidase 9, X-linked 0.0203247
PCBP2 poly(rC) binding protein 2 0.020265
CCDC14 coiled-coil domain containing 14 0.0198639
FNDC3A fibronectin type III domain containing 3A 0.0197835
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0196557
HOOK2 hook microtubule-tethering protein 2 0.019534
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0191028
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.018912
NPTN neuroplastin 0.0186847
SUCO SUN domain containing ossification factor 0.0182248
RAP1B RAP1B, member of RAS oncogene family 0.0180646
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.017952
SPAG9 sperm associated antigen 9 0.0179177
SNX9 sorting nexin 9 0.0178871
MARCHF6 membrane associated ring-CH-type finger 6 0.0178815
SFPQ splicing factor proline/glutamine-rich 0.0177775
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.017686
PUM2 pumilio RNA-binding family member 2 0.0176638
FRMD6 FERM domain containing 6 0.0175518
CCNL1 cyclin L1 0.0174918
UGCG UDP-glucose ceramide glucosyltransferase 0.0172985
NCKAP1 NCK-associated protein 1 0.0172838
ANLN anillin, actin binding protein 0.0170913
COPA coatomer protein complex, subunit alpha 0.0170603
SDC4 syndecan 4 0.017012
KMT2E lysine (K)-specific methyltransferase 2E 0.0164001
FAT1 FAT atypical cadherin 1 0.0163194
RASA2 RAS p21 protein activator 2 0.0162203
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0162016
IGF2R insulin-like growth factor 2 receptor 0.0159593
ANKRD10 ankyrin repeat domain 10 0.0159144
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0158623
FXR1 fragile X mental retardation, autosomal homolog 1 0.0156641
DPY19L1 dpy-19-like 1 (C. elegans) 0.0156517
ANXA5 annexin A5 0.0156269
PCM1 pericentriolar material 1 0.0154744
BHLHE40 basic helix-loop-helix family, member e40 0.01537
TMSB4X thymosin beta 4, X-linked 0.0153541
TNIP1 TNFAIP3 interacting protein 1 0.015295
PTBP2 polypyrimidine tract binding protein 2 0.0152924
CENPF centromere protein F, 350/400kDa 0.0152924
GNG12 guanine nucleotide binding protein (G protein), gamma 12 0.0152726
RSRC2 arginine/serine-rich coiled-coil 2 0.0152176
RSF1 remodeling and spacing factor 1 0.0150555
RBM25 RNA binding motif protein 25 0.0148562
CADM1 cell adhesion molecule 1 0.0148109
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0147439
SGO2 shugoshin 2 0.0147423
GRB10 growth factor receptor-bound protein 10 0.0147029
BRWD3 bromodomain and WD repeat domain containing 3 0.0146576
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0145404
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0145341
AUTS2 autism susceptibility candidate 2 0.0144543
KDM3A lysine (K)-specific demethylase 3A 0.014408
SCAF8 SR-related CTD-associated factor 8 0.0143292
ZFC3H1 zinc finger, C3H1-type containing 0.0142588
CD109 CD109 molecule 0.0141528
IWS1 IWS1 homolog (S. cerevisiae) 0.0141496
CD46 CD46 molecule, complement regulatory protein 0.01407
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0139303
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0139086
DMTF1 cyclin D binding myb-like transcription factor 1 0.0138698
SFXN1 sideroflexin 1 0.0138364

decreased expression

Symbol Name Standardized Value
TGFBI transforming growth factor, beta-induced, 68kDa -0.217591
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.181474
IGFBP3 insulin-like growth factor binding protein 3 -0.178925
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.174414
VIM vimentin -0.14586
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.128496
HLA-B major histocompatibility complex, class I, B -0.101826
TMSB10 thymosin beta 10 -0.100389
FN1 fibronectin 1 -0.0849125
FTL ferritin, light polypeptide -0.0738148
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0713666
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0692041
TPT1 tumor protein, translationally-controlled 1 -0.0607219
F3 coagulation factor III (thromboplastin, tissue factor) -0.0606718
PTMA prothymosin, alpha -0.0563103
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0525763
COL1A1 collagen, type I, alpha 1 -0.0507806
POTEF POTE ankyrin domain family, member F -0.0480244
ENO1 enolase 1, (alpha) -0.0464405
HLA-C major histocompatibility complex, class I, C -0.045983
MT2A metallothionein 2A -0.0430826
COL5A1 collagen, type V, alpha 1 -0.0427158
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0426631
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0401564
CALR calreticulin -0.037885
EGFR epidermal growth factor receptor -0.0374623
TPM4 tropomyosin 4 -0.0358845
VDAC1 voltage-dependent anion channel 1 -0.0354286
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0349533
HLA-A major histocompatibility complex, class I, A -0.0338773
PRSS23 protease, serine, 23 -0.033827
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0329013
VCL vinculin -0.0324809
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0321293
RPL37A ribosomal protein L37a -0.0304495
NDRG1 N-myc downstream regulated 1 -0.0299747
CANX calnexin -0.029939
KTN1 kinectin 1 (kinesin receptor) -0.0296988
RRBP1 ribosome binding protein 1 -0.0295528
RPL35A ribosomal protein L35a -0.0290802
CAVIN1 caveolae associated protein 1 -0.0284305
PSD3 pleckstrin and Sec7 domain containing 3 -0.0276671
RPL34 ribosomal protein L34 -0.0276549
S100A6 S100 calcium binding protein A6 -0.0274293
HM13 histocompatibility (minor) 13 -0.0273111
RPLP1 ribosomal protein, large, P1 -0.0272344
RPS8 ribosomal protein S8 -0.0272138
PKM pyruvate kinase, muscle -0.0270249
PGK1 phosphoglycerate kinase 1 -0.0268266
COPB1 coatomer protein complex, subunit beta 1 -0.0264875
EIF1 eukaryotic translation initiation factor 1 -0.0259259
RPS23 ribosomal protein S23 -0.0254287
RPL37 ribosomal protein L37 -0.0249674
PDIA3 protein disulfide isomerase family A, member 3 -0.0249271
DSTN destrin (actin depolymerizing factor) -0.0244492
LMAN1 lectin, mannose-binding, 1 -0.0243825
CDH13 cadherin 13 -0.0242598
COL6A1 collagen, type VI, alpha 1 -0.0239168
GLIS3 GLIS family zinc finger 3 -0.0238916
LDHA lactate dehydrogenase A -0.0238377
S100A10 S100 calcium binding protein A10 -0.0228476
ADM adrenomedullin -0.0226734
RPL15 ribosomal protein L15 -0.0221787
RPL23 ribosomal protein L23 -0.0219767
CSNK1A1 casein kinase 1, alpha 1 -0.0217932
CALU calumenin -0.0216413
ENO2 enolase 2 (gamma, neuronal) -0.0213996
WSB1 WD repeat and SOCS box containing 1 -0.0213882
RPL11 ribosomal protein L11 -0.0211527
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0210314
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0209342
RPS6 ribosomal protein S6 -0.0209213
DPYD dihydropyrimidine dehydrogenase -0.0209144
VEGFA vascular endothelial growth factor A -0.0208938
TGFB1 transforming growth factor, beta 1 -0.0205441
SPDYA speedy/RINGO cell cycle regulator family member A -0.0203459
GCC2 GRIP and coiled-coil domain containing 2 -0.0202513
FLOT1 flotillin 1 -0.0200939
EXT1 exostosin glycosyltransferase 1 -0.0200872
RPL31 ribosomal protein L31 -0.0199007
RPLP2 ribosomal protein, large, P2 -0.0198991
STC1 stanniocalcin 1 -0.0194384
S100A9 S100 calcium binding protein A9 -0.0193575
UBC ubiquitin C -0.0192732
LOX lysyl oxidase -0.0191129
ACTG1 actin gamma 1 -0.0191077
NAV1 neuron navigator 1 -0.0189442
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0189214
EGR1 early growth response 1 -0.018839
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0187216
LMNA lamin A/C -0.0186882
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 -0.0185507
YIPF5 Yip1 domain family, member 5 -0.0185114
TBCA tubulin folding cofactor A -0.0185026
DDIT4 DNA-damage-inducible transcript 4 -0.0184394
TRIM56 tripartite motif containing 56 -0.0184191
COL7A1 collagen, type VII, alpha 1 -0.0182291
STC2 stanniocalcin 2 -0.0178096
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) -0.0177301
RPS13 ribosomal protein S13 -0.0176102