v-crk avian sarcoma virus CT10 oncogene homolog|This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1398)
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22 genes co-occuring with the biological term crk in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
