crkl Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description v-crk avian sarcoma virus CT10 oncogene homolog-like|This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009] (NCBI Entrez Gene Database, 1399)
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Genes

26 genes co-occuring with the biological term crkl in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
BCR breakpoint cluster region
CASP8 caspase 8, apoptosis-related cysteine peptidase
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CD200R1 CD200 receptor 1
CD34 CD34 molecule
CR2 complement component (3d/Epstein Barr virus) receptor 2
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
DOCK2 dedicator of cytokinesis 2
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DOK2 docking protein 2, 56kDa
ESR1 estrogen receptor 1
GRB2 growth factor receptor-bound protein 2
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
KLRK1 killer cell lectin-like receptor subfamily K, member 1
MAPK1 mitogen-activated protein kinase 1
MIR126 microRNA 126
NEWENTRY Record to support submission of GeneRIFs for a gene not in Gene (human; man).
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STMN1 stathmin 1
SYK spleen tyrosine kinase
VAV1 vav 1 guanine nucleotide exchange factor