crypt Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A crypt is a deep pit that protrudes down into the connective tissue surrounding the small intestine. The epithelium at the base of the crypt is the site of stem cell proliferation and the differentiated cells move upwards and are shed 3-5 days later at the tips of the villi. (BRENDA Tissue and Enzyme Source Ontology, BTO_0000305)
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Genes

34 genes co-occuring with the biological term crypt in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ALPK2 alpha-kinase 2
APC adenomatous polyposis coli
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BRAF B-Raf proto-oncogene, serine/threonine kinase
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDKN2A cyclin-dependent kinase inhibitor 2A
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
E2F4 E2F transcription factor 4, p107/p130-binding
ESR1 estrogen receptor 1
HES1 hes family bHLH transcription factor 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
IGF2 insulin-like growth factor 2
IGFBP3 insulin-like growth factor binding protein 3
ITGA8 integrin, alpha 8
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
KRAS Kirsten rat sarcoma viral oncogene homolog
LGALS1 lectin, galactoside-binding, soluble, 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MLH1 mutL homolog 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTX3 pentraxin 3, long
REG1A regenerating islet-derived 1 alpha
RHOA ras homolog family member A
RSPO1 R-spondin 1
SLC43A2 solute carrier family 43 (amino acid system L transporter), member 2
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8
SOX9 SRY (sex determining region Y)-box 9
TGFA transforming growth factor, alpha
TP53 tumor protein p53