crypt Gene Set

Dataset TISSUES Text-mining Tissue Protein Expression Evidence Scores
Category structural or functional annotations
Type tissue
Description A crypt is a deep pit that protrudes down into the connective tissue surrounding the small intestine. The epithelium at the base of the crypt is the site of stem cell proliferation and the differentiated cells move upwards and are shed 3-5 days later at the tips of the villi. (BRENDA Tissue and Enzyme Source Ontology, BTO_0000305)
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Genes

718 proteins co-occuring with the tissue crypt in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.

Symbol Name Standardized Value
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 2.53126
LCT lactase 2.26852
SI sucrase-isomaltase (alpha-glucosidase) 2.10005
DEFA5 defensin, alpha 5, Paneth cell-specific 1.99056
PCNA proliferating cell nuclear antigen 1.9736
LYZ lysozyme 1.83631
MUC2 mucin 2, oligomeric mucus/gel-forming 1.82196
DCLK1 doublecortin-like kinase 1 1.7753
NOD2 nucleotide-binding oligomerization domain containing 2 1.64306
APC adenomatous polyposis coli 1.63856
ALPPL2 alkaline phosphatase, placental-like 2 1.62257
ALPL alkaline phosphatase, liver/bone/kidney 1.62207
ALPP alkaline phosphatase, placental 1.62108
ODC1 ornithine decarboxylase 1 1.57601
CDX2 caudal type homeobox 2 1.56915
CD79A CD79a molecule, immunoglobulin-associated alpha 1.56525
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) 1.55067
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 1.52999
TP53 tumor protein p53 1.52331
GCG glucagon 1.51237
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.50953
GAST gastrin 1.42599
DEFA6 defensin, alpha 6, Paneth cell-specific 1.42183
CDX1 caudal type homeobox 1 1.41215
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 1.39651
CCND1 cyclin D1 1.38734
KRAS Kirsten rat sarcoma viral oncogene homolog 1.38367
PYY peptide YY 1.37636
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.36313
ANPEP alanyl (membrane) aminopeptidase 1.32596
HRAS Harvey rat sarcoma viral oncogene homolog 1.28547
ALPI alkaline phosphatase, intestinal 1.28412
BAX BCL2-associated X protein 1.2662
OLFM4 olfactomedin 4 1.25592
EPHB2 EPH receptor B2 1.24253
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.23851
GLP2R glucagon-like peptide 2 receptor 1.22648
IGF1 insulin-like growth factor 1 (somatomedin C) 1.22514
TFF3 trefoil factor 3 (intestinal) 1.22469
IRGM immunity-related GTPase family, M 1.2149
GPX2 glutathione peroxidase 2 1.20111
SOX9 SRY (sex determining region Y)-box 9 1.19889
HNF4A hepatocyte nuclear factor 4, alpha 1.19489
HFE hemochromatosis 1.17491
FABP1 fatty acid binding protein 1, liver 1.16205
IL11 interleukin 11 1.15761
MPO myeloperoxidase 1.15628
MMP7 matrix metallopeptidase 7 1.15096
ATOH1 atonal homolog 1 (Drosophila) 1.1421
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 1.13767
CLDN7 claudin 7 1.13412
DPP4 dipeptidyl-peptidase 4 1.12305
OCLN occludin 1.11818
FGF7 fibroblast growth factor 7 1.1142
DNTT DNA nucleotidylexotransferase 1.11331
GSTA3 glutathione S-transferase alpha 3 1.10889
GSTA4 glutathione S-transferase alpha 4 1.10668
GSTA2 glutathione S-transferase alpha 2 1.10624
CSN1S1 casein alpha s1 1.10181
GSTA1 glutathione S-transferase alpha 1 1.10137
CD4 CD4 molecule 1.09739
MLH1 mutL homolog 1 1.09562
DEFA1B defensin, alpha 1B 1.09341
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.08501
CHGA chromogranin A 1.0806
SST somatostatin 1.07927
DEFA1 defensin, alpha 1 1.07618
MUC3A mucin 3A, cell surface associated 1.07529
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 1.07441
KLF5 Kruppel-like factor 5 (intestinal) 1.07397
RSPO1 R-spondin 1 1.07132
SLC26A3 solute carrier family 26 (anion exchanger), member 3 1.06956
NOTCH1 notch 1 1.05897
LAP3 leucine aminopeptidase 3 1.05589
TLR4 toll-like receptor 4 1.05457
CLDN1 claudin 1 1.05281
CLDN15 claudin 15 1.05237
TGFB1 transforming growth factor, beta 1 1.02776
MSI1 musashi RNA-binding protein 1 1.01637
BMI1 BMI1 proto-oncogene, polycomb ring finger 1.01418
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 1.00545
CLDN3 claudin 3 1.00196
TREH trehalase (brush-border membrane glycoprotein) 0.998473
MSH2 mutS homolog 2 0.984122
MUC5B mucin 5B, oligomeric mucus/gel-forming 0.984122
CD44 CD44 molecule (Indian blood group) 0.981084
VIL1 villin 1 0.973716
NEUROG3 neurogenin 3 0.971984
KRT20 keratin 20, type I 0.966793
DEFA4 defensin, alpha 4, corticostatin 0.965928
SOBP sine oculis binding protein homolog (Drosophila) 0.961175
PLA2G1B phospholipase A2, group IB (pancreas) 0.961175
GANAB glucosidase, alpha; neutral AB 0.961175
PTCH1 patched 1 0.956859
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7 0.946087
MUC6 mucin 6, oligomeric mucus/gel-forming 0.939206
TNF tumor necrosis factor 0.932337
VIP vasoactive intestinal peptide 0.930193
DEFA3 defensin, alpha 3, neutrophil-specific 0.928478
MKI67 marker of proliferation Ki-67 0.920344
EPHB3 EPH receptor B3 0.918206
INS insulin 0.911373
IHH indian hedgehog 0.90924
ASCL2 achaete-scute family bHLH transcription factor 2 0.900296
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 0.894346
MYD88 myeloid differentiation primary response 88 0.893921
LTF lactotransferrin 0.888829
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.887133
MIB1 mindbomb E3 ubiquitin protein ligase 1 0.879512
TJP1 tight junction protein 1 0.878666
TFRC transferrin receptor 0.873172
ADSL adenylosuccinate lyase 0.869373
SOD2 superoxide dismutase 2, mitochondrial 0.862627
GPX1 glutathione peroxidase 1 0.85505
CASR calcium-sensing receptor 0.851686
WNT5A wingless-type MMTV integration site family, member 5A 0.839091
GANC glucosidase, alpha; neutral C 0.835737
DNAH8 dynein, axonemal, heavy chain 8 0.833642
BCL2 B-cell CLL/lymphoma 2 0.832385
FZD5 frizzled class receptor 5 0.828197
TFF2 trefoil factor 2 0.824849
EGFR epidermal growth factor receptor 0.821502
REG3A regenerating islet-derived 3 alpha 0.818576
KCNE3 potassium channel, voltage gated subfamily E regulatory beta subunit 3 0.816068
ISX intestine-specific homeobox 0.814397
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 0.813979
IL1B interleukin 1, beta 0.811891
CAT catalase 0.809386
KLF4 Kruppel-like factor 4 (gut) 0.807716
GPX4 glutathione peroxidase 4 0.802293
NTS neurotensin 0.797291
GPX5 glutathione peroxidase 5 0.791044
BBS2 Bardet-Biedl syndrome 2 0.786468
CCK cholecystokinin 0.783557
HOPX HOP homeobox 0.773589
SFRP5 secreted frizzled-related protein 5 0.769027
ACPP acid phosphatase, prostate 0.769027
TF transferrin 0.766539
ORMDL3 ORMDL sphingolipid biosynthesis regulator 3 0.762397
ALB albumin 0.760328
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 0.759914
TGM2 transglutaminase 2 0.759086
FABP2 fatty acid binding protein 2, intestinal 0.757432
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.757018
BIRC5 baculoviral IAP repeat containing 5 0.752057
LRP6 low density lipoprotein receptor-related protein 6 0.751645
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 0.74009
CD68 CD68 molecule 0.735971
CLDN4 claudin 4 0.724453
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 0.719934
MCM2 minichromosome maintenance complex component 2 0.719524
GRP gastrin-releasing peptide 0.717472
PPY pancreatic polypeptide 0.71583
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 0.71501
DEFB113 defensin, beta 113 0.70968
CDKN2A cyclin-dependent kinase inhibitor 2A 0.70927
GUSB glucuronidase, beta 0.706812
IGFBP3 insulin-like growth factor binding protein 3 0.705583
AK6 adenylate kinase 6 0.70108
SLC26A6 solute carrier family 26 (anion exchanger), member 6 0.700671
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 0.699444
AGR2 anterior gradient 2 0.691676
SFRP2 secreted frizzled-related protein 2 0.690859
FOS FBJ murine osteosarcoma viral oncogene homolog 0.689634
AXIN2 axin 2 0.684327
EFNB1 ephrin-B1 0.67821
ZNRF3 zinc and ring finger 3 0.673321
FTL ferritin, light polypeptide 0.672506
RNF43 ring finger protein 43 0.671692
TAC1 tachykinin, precursor 1 0.667215
HEPH hephaestin 0.666809
FTH1 ferritin, heavy polypeptide 1 0.664775
GUCY2C guanylate cyclase 2C 0.663555
TLR5 toll-like receptor 5 0.660304
TLR2 toll-like receptor 2 0.659897
WNT3A wingless-type MMTV integration site family, member 3A 0.658272
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.656648
IL6 interleukin 6 0.654618
PPARG peroxisome proliferator-activated receptor gamma 0.653807
MUC4 mucin 4, cell surface associated 0.6461
FASLG Fas ligand (TNF superfamily, member 6) 0.640023
REG1A regenerating islet-derived 1 alpha 0.640023
ANGPT4 angiopoietin 4 0.635572
CXCL8 chemokine (C-X-C motif) ligand 8 0.633549
MCM7 minichromosome maintenance complex component 7 0.63274
SFRP1 secreted frizzled-related protein 1 0.631527
SSUH2 ssu-2 homolog (C. elegans) 0.625465
ALPK2 alpha-kinase 2 0.623043
TCF7 transcription factor 7 (T-cell specific, HMG-box) 0.619007
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.61699
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 0.614974
EXOSC10 exosome component 10 0.613361
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.612958
JUN jun proto-oncogene 0.610943
IGHV1-2 immunoglobulin heavy variable 1-2 0.607722
SPDEF SAM pointed domain containing ETS transcription factor 0.606112
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.605709
LEP leptin 0.603697
MOGAT2 monoacylglycerol O-acyltransferase 2 0.600077
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.598067
HNF1A HNF1 homeobox A 0.596058
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.593649
PROM1 prominin 1 0.59124
BCL2L1 BCL2-like 1 0.590839
GSAP gamma-secretase activating protein 0.587228
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 0.586026
FN1 fibronectin 1 0.58242
TELO2 telomere maintenance 2 0.581618
IER5L immediate early response 5-like 0.581618
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 0.581218
FAM53B family with sequence similarity 53, member B 0.580818
ACTB actin, beta 0.580017
TMPRSS15 transmembrane protease, serine 15 0.579216
GLB1 galactosidase, beta 1 0.574017
KRT7 keratin 7, type II 0.572818
ICAM1 intercellular adhesion molecule 1 0.569622
TNC tenascin C 0.566828
NONO non-POU domain containing, octamer-binding 0.565232
CLDN10 claudin 10 0.564434
KRT8 keratin 8, type II 0.564434
ACTG1 actin gamma 1 0.562441
DKK1 dickkopf WNT signaling pathway inhibitor 1 0.559652
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.552093
LZTFL1 leucine zipper transcription factor-like 1 0.550503
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1 0.549709
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2 0.548914
ENO2 enolase 2 (gamma, neuronal) 0.546136
CDK4 cyclin-dependent kinase 4 0.545739
TRAC T cell receptor alpha constant 0.543756
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.543756
GSR glutathione reductase 0.54217
MGAM maltase-glucoamylase 0.541377
FABP6 fatty acid binding protein 6, ileal 0.539396
FZD6 frizzled class receptor 6 0.539396
SOAT2 sterol O-acyltransferase 2 0.539
EREG epiregulin 0.537416
FFAR2 free fatty acid receptor 2 0.535042
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10 0.534251
CA7 carbonic anhydrase VII 0.533065
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.529113
ELMO3 engulfment and cell motility 3 0.521223
HIST2H3PS2 histone cluster 2, H3, pseudogene 2 0.516104
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 0.514136
SPINK1 serine peptidase inhibitor, Kazal type 1 0.51335
UBE2D1 ubiquitin-conjugating enzyme E2D 1 0.51335
MUC13 mucin 13, cell surface associated 0.512564
H3F3A H3 histone, family 3A 0.511384
XBP1 X-box binding protein 1 0.511384
H3F3B H3 histone, family 3B (H3.3B) 0.511384
FZD7 frizzled class receptor 7 0.510992
S100G S100 calcium binding protein G 0.50275
PARP1 poly (ADP-ribose) polymerase 1 0.502357
RBP1 retinol binding protein 1, cellular 0.501574
DEFB104B defensin, beta 104B 0.495701
RIPK3 receptor-interacting serine-threonine kinase 3 0.489838
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 0.489057
APOA4 apolipoprotein A-IV 0.487886
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7 0.487496
SAP30L SAP30-like 0.486326
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 0.485545
CCL20 chemokine (C-C motif) ligand 20 0.485156
AREG amphiregulin 0.484766
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 0.484376
CLDN8 claudin 8 0.483596
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 0.482038
UGT1A5 UDP glucuronosyltransferase 1 family, polypeptide A5 0.482038
WNT3 wingless-type MMTV integration site family, member 3 0.48087
KRT18 keratin 18, type I 0.48087
TICAM2 toll-like receptor adaptor molecule 2 0.479702
SMAD4 SMAD family member 4 0.479312
UGT1A4 UDP glucuronosyltransferase 1 family, polypeptide A4 0.479312
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.476979
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.476589
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.475423
GATA4 GATA binding protein 4 0.475423
TBCE tubulin folding cofactor E 0.474646
BANF2 barrier to autointegration factor 2 0.472704
IL15 interleukin 15 0.472704
MYB v-myb avian myeloblastosis viral oncogene homolog 0.471927
PDZK1 PDZ domain containing 1 0.469599
CPA5 carboxypeptidase A5 0.469211
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.468436
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.468048
UGT1A3 UDP glucuronosyltransferase 1 family, polypeptide A3 0.466498
GAA glucosidase, alpha; acid 0.464561
BBC3 BCL2 binding component 3 0.4634
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 0.462626
PLA2G10 phospholipase A2, group X 0.462239
UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9 0.460692
CYBRD1 cytochrome b reductase 1 0.455284
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.454126
E2F4 E2F transcription factor 4, p107/p130-binding 0.454126
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain 0.453355
RAB3D RAB3D, member RAS oncogene family 0.452198
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 0.451428
IL17A interleukin 17A 0.449116
ENPEP glutamyl aminopeptidase (aminopeptidase A) 0.448346
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 0.447576
BMPR1A bone morphogenetic protein receptor, type IA 0.447192
SMOC2 SPARC related modular calcium binding 2 0.443731
LAMB2 laminin, beta 2 (laminin S) 0.44181
FAM3D family with sequence similarity 3, member D 0.441426
FCGBP Fc fragment of IgG binding protein 0.440658
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.43989
GLS glutaminase 0.436822
PGLYRP1 peptidoglycan recognition protein 1 0.436822
IGF2 insulin-like growth factor 2 0.436055
IL10 interleukin 10 0.436055
CCL25 chemokine (C-C motif) ligand 25 0.435289
REG1B regenerating islet-derived 1 beta 0.434906
RNASEH2A ribonuclease H2, subunit A 0.434523
CA1 carbonic anhydrase I 0.432225
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 0.430312
FZD1 frizzled class receptor 1 0.428401
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) 0.425726
CAMP cathelicidin antimicrobial peptide 0.425726
CCNE1 cyclin E1 0.425344
ZNF830 zinc finger protein 830 0.423436
SLC6A19 solute carrier family 6 (neutral amino acid transporter), member 19 0.423436
TFF1 trefoil factor 1 0.423054
PAQR7 progestin and adipoQ receptor family member VII 0.422673
KIAA1456 KIAA1456 0.42191
IFT54 intraflagellar transport 54 0.421529
NR3C2 nuclear receptor subfamily 3, group C, member 2 0.421148
ERN2 endoplasmic reticulum to nucleus signaling 2 0.419623
LGR6 leucine-rich repeat containing G protein-coupled receptor 6 0.418861
FOXF2 forkhead box F2 0.416195
ILK integrin-linked kinase 0.415434
ERCC1 excision repair cross-complementation group 1 0.414293
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent) 0.414293
EID2B EP300 interacting inhibitor of differentiation 2B 0.413532
SND1 staphylococcal nuclease and tudor domain containing 1 0.412011
CXCL5 chemokine (C-X-C motif) ligand 5 0.408212
STK11 serine/threonine kinase 11 0.404797
NFE2L2 nuclear factor, erythroid 2-like 2 0.40366
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 0.402901
HBEGF heparin-binding EGF-like growth factor 0.402144
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.401765
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 0.401386
NKX2-3 NK2 homeobox 3 0.399871
REG4 regenerating islet-derived family, member 4 0.3976
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 0.396465
IL1A interleukin 1, alpha 0.395709
NEUROD1 neuronal differentiation 1 0.395331
HAMP hepcidin antimicrobial peptide 0.394953
ACSL5 acyl-CoA synthetase long-chain family member 5 0.391931
ZNF382 zinc finger protein 382 0.391176
FGFR2 fibroblast growth factor receptor 2 0.390799
GIP gastric inhibitory polypeptide 0.390799
RBP2 retinol binding protein 2, cellular 0.389289
GLS2 glutaminase 2 (liver, mitochondrial) 0.384766
CELF2 CUGBP, Elav-like family member 2 0.384766
SYP synaptophysin 0.38439
CASD1 CAS1 domain containing 1 0.38326
REG3G regenerating islet-derived 3 gamma 0.381379
HLA-B major histocompatibility complex, class I, B 0.379499
UCK1 uridine-cytidine kinase 1 0.379499
GLI1 GLI family zinc finger 1 0.377621
EPGN epithelial mitogen 0.377245
UCKL1 uridine-cytidine kinase 1-like 1 0.377245
ESR2 estrogen receptor 2 (ER beta) 0.376119
TLR9 toll-like receptor 9 0.375743
SHH sonic hedgehog 0.373868
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) 0.371619
SPINK4 serine peptidase inhibitor, Kazal type 4 0.371245
RSPO2 R-spondin 2 0.37087
VIMP VCP-interacting membrane selenoprotein 0.370121
DLL1 delta-like 1 (Drosophila) 0.369373
TOP1 topoisomerase (DNA) I 0.368998
CARD17 caspase recruitment domain family, member 17 0.368998
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.367129
PPARD peroxisome proliferator-activated receptor delta 0.366754
H2AFX H2A histone family, member X 0.366381
GGT2 gamma-glutamyltransferase 2 0.366381
MUC17 mucin 17, cell surface associated 0.363393
SLC38A5 solute carrier family 38, member 5 0.360036
C1GALT1C1 C1GALT1-specific chaperone 1 0.360036
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 0.359664
TERT telomerase reverse transcriptase 0.358919
DMBT1 deleted in malignant brain tumors 1 0.35743
MNX1 motor neuron and pancreas homeobox 1 0.357058
CCND2 cyclin D2 0.356686
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 0.356314
TMTC1 transmembrane and tetratricopeptide repeat containing 1 0.35557
DLL4 delta-like 4 (Drosophila) 0.355198
DTX3 deltex 3, E3 ubiquitin ligase 0.355198
CLDN14 claudin 14 0.354826
IGF1R insulin-like growth factor 1 receptor 0.354455
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 0.354084
NOX1 NADPH oxidase 1 0.352598
BTC betacellulin 0.351114
PRG1 p53-responsive gene 1 0.350001
IER3 immediate early response 3 0.34963
JAG2 jagged 2 0.34926
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.348889
GFI1 growth factor independent 1 transcription repressor 0.348889
CALB1 calbindin 1, 28kDa 0.348148
UCK2 uridine-cytidine kinase 2 0.347778
NRG4 neuregulin 4 0.347038
NEU2 sialidase 2 (cytosolic sialidase) 0.346668
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase) 0.34334
AXIN1 axin 1 0.341126
TSPO translocator protein (18kDa) 0.340757
LGALS7 lectin, galactoside-binding, soluble, 7 0.340019
AHCTF1 AT hook containing transcription factor 1 0.338914
MS4A8 membrane-spanning 4-domains, subfamily A, member 8 0.338177
SMAD3 SMAD family member 3 0.337808
SLC5A11 solute carrier family 5 (sodium/inositol cotransporter), member 11 0.336336
CRIP1 cysteine-rich protein 1 (intestinal) 0.335968
MLN motilin 0.335968
GGT1 gamma-glutamyltransferase 1 0.334865
PAOX polyamine oxidase (exo-N4-amino) 0.334498
NOG noggin 0.333396
JAG1 jagged 1 0.333396
RAB2B RAB2B, member RAS oncogene family 0.333396
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 0.330094
NPR1 natriuretic peptide receptor 1 0.329361
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.326432
NIN ninein (GSK3B interacting protein) 0.325335
PIGR polymeric immunoglobulin receptor 0.323874
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.322779
MOGAT3 monoacylglycerol O-acyltransferase 3 0.320227
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 0.320227
GATA6 GATA binding protein 6 0.319863
CDK2 cyclin-dependent kinase 2 0.316951
CHODL chondrolectin 0.316224
FGF1 fibroblast growth factor 1 (acidic) 0.315498
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 0.314772
TTC7A tetratricopeptide repeat domain 7A 0.314772
ICK intestinal cell (MAK-like) kinase 0.308612
FZD4 frizzled class receptor 4 0.308251
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 0.307889
G6PD glucose-6-phosphate dehydrogenase 0.303919
PRKG2 protein kinase, cGMP-dependent, type II 0.298524
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.297806
CRIPT cysteine-rich PDZ-binding protein 0.297447
CSF1R colony stimulating factor 1 receptor 0.297447
APOLD1 apolipoprotein L domain containing 1 0.297447
PTGER4 prostaglandin E receptor 4 (subtype EP4) 0.296372
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.291365
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.289582
TUSC2 tumor suppressor candidate 2 0.288514
FRZB frizzled-related protein 0.288158
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.284962
TGFB3 transforming growth factor, beta 3 0.284962
PTEN phosphatase and tensin homolog 0.28213
SLC19A1 solute carrier family 19 (folate transporter), member 1 0.280364
EZR ezrin 0.280012
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 0.279659
PNLIP pancreatic lipase 0.279307
TGFA transforming growth factor, alpha 0.2779
SLC44A4 solute carrier family 44, member 4 0.277314
LCMT2 leucine carboxyl methyltransferase 2 0.277197
XPR1 xenotropic and polytropic retrovirus receptor 1 0.276495
ADA adenosine deaminase 0.274394
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 0.269521
MAPK14 mitogen-activated protein kinase 14 0.269521
CEP55 centrosomal protein 55kDa 0.267446
RPS29 ribosomal protein S29 0.266757
MYO1A myosin IA 0.266413
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 0.266413
GSTM2 glutathione S-transferase mu 2 (muscle) 0.265381
STAG1 stromal antigen 1 0.263327
HSPA4 heat shock 70kDa protein 4 0.262304
TFR2 transferrin receptor 2 0.262304
MET MET proto-oncogene, receptor tyrosine kinase 0.261624
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.261284
LAYN layilin 0.260945
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 0.259254
CAPN9 calpain 9 0.257572
TLR3 toll-like receptor 3 0.257572
LTB4R2 leukotriene B4 receptor 2 0.257572
FZD8 frizzled class receptor 8 0.256234
HDAC3 histone deacetylase 3 0.255567
NPY neuropeptide Y 0.255567
GSTP1 glutathione S-transferase pi 1 0.255567
DCC DCC netrin 1 receptor 0.255234
CD34 CD34 molecule 0.252261
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 0.251279
PPIC peptidylprolyl isomerase C (cyclophilin C) 0.250627
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.249653
AMACR alpha-methylacyl-CoA racemase 0.248361
POR P450 (cytochrome) oxidoreductase 0.24804
MUC1 mucin 1, cell surface associated 0.247399
MIRLET7A3 microRNA let-7a-3 0.246442
BARX1 BARX homeobox 1 0.246124
CACTIN cactin, spliceosome C complex subunit 0.244232
LGALS1 lectin, galactoside-binding, soluble, 1 0.243918
WIF1 WNT inhibitory factor 1 0.243918
MAPK11 mitogen-activated protein kinase 11 0.243605
ITLN2 intelectin 2 0.240216
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 0.239913
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 0.238406
RPLP0 ribosomal protein, large, P0 0.238108
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 0.238108
FGGY FGGY carbohydrate kinase domain containing 0.23781
TFIP11 tuftelin interacting protein 11 0.235943
ESR1 estrogen receptor 1 0.234016
AQP8 aquaporin 8 0.234016
PITRM1 pitrilysin metallopeptidase 1 0.234016
CYHR1 cysteine/histidine-rich 1 0.233731
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 0.233446
DEFB4A defensin, beta 4A 0.233446
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.232599
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.23176
APOC3 apolipoprotein C-III 0.231206
GLI3 GLI family zinc finger 3 0.231206
CD24 CD24 molecule 0.229839
C19ORF33 chromosome 19 open reading frame 33 0.229299
CDC25A cell division cycle 25A 0.228497
GHRL ghrelin/obestatin prepropeptide 0.228234
SLFN12 schlafen family member 12 0.227707
SLC39A4 solute carrier family 39 (zinc transporter), member 4 0.226926
CA2 carbonic anhydrase II 0.226667
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 0.2259
DEFB103A defensin, beta 103A 0.225395
CLDN6 claudin 6 0.224398
SAP30 Sin3A-associated protein, 30kDa 0.223177
NOS2 nitric oxide synthase 2, inducible 0.22246
ADAMTSL3 ADAMTS-like 3 0.22246
LIPF lipase, gastric 0.22246
PTHLH parathyroid hormone-like hormone 0.220831
NAALADL1 N-acetylated alpha-linked acidic dipeptidase-like 1 0.220831
LPA lipoprotein, Lp(a) 0.220604
TIPRL TOR signaling pathway regulator 0.219707
TBXAS1 thromboxane A synthase 1 (platelet) 0.219264
CDC25B cell division cycle 25B 0.218613
XRN2 5'-3' exoribonuclease 2 0.218398
B2M beta-2-microglobulin 0.218398
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 0.217974
HES1 hes family bHLH transcription factor 1 0.217762
RAB21 RAB21, member RAS oncogene family 0.217554
GINS4 GINS complex subunit 4 (Sld5 homolog) 0.217346
PTAFR platelet-activating factor receptor 0.216528
LDB2 LIM domain binding 2 0.216325
RHBG Rh family, B glycoprotein (gene/pseudogene) 0.215928
PRAMEF10 PRAME family member 10 0.21573
IL4R interleukin 4 receptor 0.215147
CCNB1 cyclin B1 0.214954
GREM2 gremlin 2, DAN family BMP antagonist 0.214954
PTPN3 protein tyrosine phosphatase, non-receptor type 3 0.214576
HHIP hedgehog interacting protein 0.214388
HMOX1 heme oxygenase 1 0.214202
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.21365
EPCAM epithelial cell adhesion molecule 0.213471
MOGAT1 monoacylglycerol O-acyltransferase 1 0.212936
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) 0.212413
GPR39 G protein-coupled receptor 39 0.206202
RPS11 ribosomal protein S11 0.20586
MS4A12 membrane-spanning 4-domains, subfamily A, member 12 0.20387
C1RL complement component 1, r subcomponent-like 0.200467
HIBCH 3-hydroxyisobutyryl-CoA hydrolase 0.19913
NIT2 nitrilase family, member 2 0.197505
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 0.197471
PTPN2 protein tyrosine phosphatase, non-receptor type 2 0.19696
RPL27A ribosomal protein L27a 0.196698
TACR1 tachykinin receptor 1 0.196685
F2RL1 coagulation factor II (thrombin) receptor-like 1 0.196685
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.196566
PLB1 phospholipase B1 0.19654
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 0.19634
HIBADH 3-hydroxyisobutyrate dehydrogenase 0.196177
HDAC9 histone deacetylase 9 0.196177
DEFB1 defensin, beta 1 0.196177
MPST mercaptopyruvate sulfurtransferase 0.196095
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.196026
PCCB propionyl CoA carboxylase, beta polypeptide 0.195801
MUC19 mucin 19, oligomeric 0.195686
CORO1C coronin, actin binding protein, 1C 0.195679
PDE5A phosphodiesterase 5A, cGMP-specific 0.195422
SLC39A1 solute carrier family 39 (zinc transporter), member 1 0.195385
ZNF410 zinc finger protein 410 0.195302
RSPO3 R-spondin 3 0.195279
ATG7 autophagy related 7 0.195024
ENHO energy homeostasis associated 0.194809
PMEPA1 prostate transmembrane protein, androgen induced 1 0.194711
RXFP4 relaxin/insulin-like family peptide receptor 4 0.194487
ITLN1 intelectin 1 (galactofuranose binding) 0.194462
ATG4B autophagy related 4B, cysteine peptidase 0.194462
LYNX1 Ly6/neurotoxin 1 0.193748
INSL5 insulin-like 5 0.193702
ATG5 autophagy related 5 0.193675
DDIT3 DNA-damage-inducible transcript 3 0.193119
GSTM5 glutathione S-transferase mu 5 0.192518
RHOU ras homolog family member U 0.19239
FOXL1 forkhead box L1 0.192326
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.192098
SLC39A2 solute carrier family 39 (zinc transporter), member 2 0.192065
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene) 0.191987
SLC30A5 solute carrier family 30 (zinc transporter), member 5 0.191774
IL34 interleukin 34 0.191762
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene) 0.191751
ANG angiogenin, ribonuclease, RNase A family, 5 0.191716
CIDEB cell death-inducing DFFA-like effector b 0.191716
PXN paxillin 0.191213
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1 0.191141
KLK3 kallikrein-related peptidase 3 0.191104
TST thiosulfate sulfurtransferase (rhodanese) 0.19092
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 0.190821
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.190784
PDLIM1 PDZ and LIM domain 1 0.190645
WNT9A wingless-type MMTV integration site family, member 9A 0.190594
MIR21 microRNA 21 0.190569
GABPB1 GA binding protein transcription factor, beta subunit 1 0.19031
CLDN2 claudin 2 0.190245
SLC16A4 solute carrier family 16, member 4 0.190179
FOLR1 folate receptor 1 (adult) 0.189978
MIR137 microRNA 137 0.189856
SON SON DNA binding protein 0.189801
SYVN1 synovial apoptosis inhibitor 1, synoviolin 0.189788
CLDN18 claudin 18 0.189593
CXCL2 chemokine (C-X-C motif) ligand 2 0.189424
BCL10 B-cell CLL/lymphoma 10 0.189382
SHMT1 serine hydroxymethyltransferase 1 (soluble) 0.189325
MIR17 microRNA 17 0.189267
FAS Fas cell surface death receptor 0.189151
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.189093
LIN28B lin-28 homolog B (C. elegans) 0.189005
SLC19A2 solute carrier family 19 (thiamine transporter), member 2 0.188975
MECOM MDS1 and EVI1 complex locus 0.188796
RERE arginine-glutamic acid dipeptide (RE) repeats 0.188736
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.188706
PLCB2 phospholipase C, beta 2 0.18866
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.188538
LECT2 leukocyte cell-derived chemotaxin 2 0.188492
HPGDS hematopoietic prostaglandin D synthase 0.18843
CLNK cytokine-dependent hematopoietic cell linker 0.188352
KLF10 Kruppel-like factor 10 0.188336
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 0.188336
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.188273
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 0.188242
PORCN porcupine homolog (Drosophila) 0.188162
CASP5 caspase 5, apoptosis-related cysteine peptidase 0.188131
ECE1 endothelin converting enzyme 1 0.187986
ORM1 orosomucoid 1 0.187954
NPC1 Niemann-Pick disease, type C1 0.187921
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide 0.187888
CYLD cylindromatosis (turban tumor syndrome) 0.187724
CD109 CD109 molecule 0.187724
IL27 interleukin 27 0.187524
LRG1 leucine-rich alpha-2-glycoprotein 1 0.18749
CALCOCO2 calcium binding and coiled-coil domain 2 0.187474
RDH5 retinol dehydrogenase 5 (11-cis/9-cis) 0.187406
NTSR1 neurotensin receptor 1 (high affinity) 0.187372
NEK2 NIMA-related kinase 2 0.187337
MIR96 microRNA 96 0.187095
CRHR2 corticotropin releasing hormone receptor 2 0.187008
XDH xanthine dehydrogenase 0.186937
ARRB1 arrestin, beta 1 0.186848
IRF7 interferon regulatory factor 7 0.18674
MIR183 microRNA 183 0.18674
SLC30A4 solute carrier family 30 (zinc transporter), member 4 0.186318
CIRBP cold inducible RNA binding protein 0.186299
SLPI secretory leukocyte peptidase inhibitor 0.186149
GJB1 gap junction protein, beta 1, 32kDa 0.18613
MIR214 microRNA 214 0.185977
ACAT1 acetyl-CoA acetyltransferase 1 0.185977
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.185919
CDC42 cell division cycle 42 0.18588
NCBP1 nuclear cap binding protein subunit 1, 80kDa 0.18588
XCR1 chemokine (C motif) receptor 1 0.185782
PTGES2 prostaglandin E synthase 2 0.185485
CANX calnexin 0.185221
OTC ornithine carbamoyltransferase 0.18518
HMX2 H6 family homeobox 2 0.185159
TLR10 toll-like receptor 10 0.185034
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4 0.18493
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain 0.184909
CPS1 carbamoyl-phosphate synthase 1, mitochondrial 0.184653
BIRC2 baculoviral IAP repeat containing 2 0.18461
HOXB13 homeobox B13 0.184566
KLF9 Kruppel-like factor 9 0.184544
DEFB103B defensin, beta 103B 0.184544
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.184258
ADAM15 ADAM metallopeptidase domain 15 0.184056
ATF4 activating transcription factor 4 0.183712
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 0.183524
TES testin LIM domain protein 0.183453
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.18343
CHIA chitinase, acidic 0.183189
HOXA13 homeobox A13 0.182593
EGLN3 egl-9 family hypoxia-inducible factor 3 0.182567
BIRC3 baculoviral IAP repeat containing 3 0.182491
RGMB repulsive guidance molecule family member b 0.182206
MTO1 mitochondrial tRNA translation optimization 1 0.182153
DSP desmoplakin 0.1821
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.182047
HCAR2 hydroxycarboxylic acid receptor 2 0.181994
RETNLB resistin like beta 0.181967
ATP2A3 ATPase, Ca++ transporting, ubiquitous 0.181941
DR1 down-regulator of transcription 1, TBP-binding (negative cofactor 2) 0.181914
GADD45A growth arrest and DNA-damage-inducible, alpha 0.181833
AQP3 aquaporin 3 (Gill blood group) 0.181724
EGR1 early growth response 1 0.181588
DPEP1 dipeptidase 1 (renal) 0.181421
SLC2A12 solute carrier family 2 (facilitated glucose transporter), member 12 0.181225
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.18114
ATG12 autophagy related 12 0.18114
RRBP1 ribosome binding protein 1 0.180852
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.180587
JAK2 Janus kinase 2 0.180527
RIPK2 receptor-interacting serine-threonine kinase 2 0.180498
PDHX pyruvate dehydrogenase complex, component X 0.180468
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.180134
HIST2H4B histone cluster 2, H4b 0.179633
HIST1H4D histone cluster 1, H4d 0.179633
HIST1H4C histone cluster 1, H4c 0.179633
HIST1H4H histone cluster 1, H4h 0.179633
HIST1H4I histone cluster 1, H4i 0.179633
HIST1H4J histone cluster 1, H4j 0.179633
HIST1H4K histone cluster 1, H4k 0.179633
HIST1H4E histone cluster 1, H4e 0.179633
HIST1H4F histone cluster 1, H4f 0.179633
HIST1H4A histone cluster 1, H4a 0.179633
HIST1H4B histone cluster 1, H4b 0.179633
HIST2H4A histone cluster 2, H4a 0.179601
HIST4H4 histone cluster 4, H4 0.179505
HIST1H4L histone cluster 1, H4l 0.179505