cryptorchidism Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description Cryptorchidism (derived from the Greek κρυπτός, kryptos, meaning hidden and ὄρχις, orchis, meaning testicle) is the absence of one or both testes from the scrotum. It is the most common birth defect regarding male genitalia. In unique cases, cryptorchidism can develop later in life, often as late as young adulthood. About 3% of full-term and 30% of premature infant boys are born with at least one undescended testis. However, about 80% of cryptorchid testes descend by the first year of life (the majority within three months), making the true incidence of cryptorchidism around 1% overall. Cryptorchidism is distinct from monorchism the condition of having only one testicle. (Experimental Factor Ontology, EFO_0004562)
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Genes

294 genes co-occuring with the disease cryptorchidism in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
INSL3 insulin-like 3 (Leydig cell) 2.91757
RXFP2 relaxin/insulin-like family peptide receptor 2 2.24471
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 2.0338
AMH anti-Mullerian hormone 1.64218
AR androgen receptor 1.63904
DNAJB13 DnaJ (Hsp40) homolog, subfamily B, member 13 1.51457
NPBWR2 neuropeptides B/W receptor 2 1.50623
HOXA10 homeobox A10 1.49569
ANOS1 anosmin 1 1.41402
SPATA4 spermatogenesis associated 4 1.37861
ZNF215 zinc finger protein 215 1.36945
SRY sex determining region Y 1.36727
INSL6 insulin-like 6 1.36553
PROKR2 prokineticin receptor 2 1.29396
GNRHR gonadotropin-releasing hormone receptor 1.24341
ZNF214 zinc finger protein 214 1.22735
NR5A1 nuclear receptor subfamily 5, group A, member 1 1.17679
SHOC2 soc-2 suppressor of clear homolog (C. elegans) 1.16692
SHBG sex hormone-binding globulin 1.11477
INSL5 insulin-like 5 1.10931
CIRBP cold inducible RNA binding protein 1.09965
SPATA3 spermatogenesis associated 3 1.04798
TCP11L1 t-complex 11, testis-specific-like 1 1.04125
CCDC73 coiled-coil domain containing 73 1.04125
DEPDC7 DEP domain containing 7 1.04125
PROK2 prokineticin 2 1.03662
QSER1 glutamine and serine rich 1 1.0168
PTPN11 protein tyrosine phosphatase, non-receptor type 11 1.01259
MBTPS2 membrane-bound transcription factor peptidase, site 2 0.996127
CHD7 chromodomain helicase DNA binding protein 7 0.987271
STS steroid sulfatase (microsomal), isozyme S 0.974221
RTCB RNA 2',3'-cyclic phosphate and 5'-OH ligase 0.974221
WT1 Wilms tumor 1 0.966663
MID1IP1 MID1 interacting protein 1 0.961634
SOS1 son of sevenless homolog 1 (Drosophila) 0.959542
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa 0.955779
COX16 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) 0.954525
DMRT1 doublesex and mab-3 related transcription factor 1 0.93207
RXFP4 relaxin/insulin-like family peptide receptor 4 0.927519
INS insulin 0.909787
GGN gametogenetin 0.901567
RXFP3 relaxin/insulin-like family peptide receptor 3 0.88434
RLN1 relaxin 1 0.88393
FGFR1 fibroblast growth factor receptor 1 0.868777
TADA2A transcriptional adaptor 2A 0.866731
ESR1 estrogen receptor 1 0.864274
SPATA17 spermatogenesis associated 17 0.856087
PTER phosphotriesterase related 0.855268
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 0.847898
HDGFRP3 hepatoma-derived growth factor, related protein 3 0.842163
SPATA12 spermatogenesis associated 12 0.841753
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 0.836427
EXD2 exonuclease 3'-5' domain containing 2 0.835198
AP3B2 adaptor-related protein complex 3, beta 2 subunit 0.826178
MAMLD1 mastermind-like domain containing 1 0.820847
TAC3 tachykinin 3 0.812232
AMHR2 anti-Mullerian hormone receptor, type II 0.808949
MEGF8 multiple EGF-like-domains 8 0.807308
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 0.801974
RLN3 relaxin 3 0.799923
CENPL centromere protein L 0.796642
ADAM21 ADAM metallopeptidase domain 21 0.774932
SUSD6 sushi domain containing 6 0.772887
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 0.767576
STAR steroidogenic acute regulatory protein 0.761862
SLC39A9 solute carrier family 39, member 9 0.758193
DAZ1 deleted in azoospermia 1 0.757786
METAP1 methionyl aminopeptidase 1 0.753713
MYH1 myosin, heavy chain 1, skeletal muscle, adult 0.739894
SRPK3 SRSF protein kinase 3 0.726524
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3 0.724502
UBC ubiquitin C 0.716828
CALCA calcitonin-related polypeptide alpha 0.714005
DAZ2 deleted in azoospermia 2 0.712392
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4 0.710378
RPS27A ribosomal protein S27a 0.707157
ARMC4 armadillo repeat containing 4 0.703134
TACR3 tachykinin receptor 3 0.701526
NFYC nuclear transcription factor Y, gamma 0.674713
DCAF5 DDB1 and CUL4 associated factor 5 0.670333
MKX mohawk homeobox 0.668742
SLC8A3 solute carrier family 8 (sodium/calcium exchanger), member 3 0.666358
KISS1R KISS1 receptor 0.665166
RXFP1 relaxin/insulin-like family peptide receptor 1 0.663975
UBB ubiquitin B 0.65763
SRSF10 serine/arginine-rich splicing factor 10 0.648138
FSHR follicle stimulating hormone receptor 0.643797
XAGE2 X antigen family, member 2 0.636315
AFP alpha-fetoprotein 0.634742
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit 0.633169
ADAL adenosine deaminase-like 0.629635
INSL4 insulin-like 4 (placenta) 0.626888
SPRY4 sprouty homolog 4 (Drosophila) 0.615921
ARID5B AT rich interactive domain 5B (MRF1-like) 0.613183
GALNT16 polypeptide N-acetylgalactosaminyltransferase 16 0.610057
ZNF569 zinc finger protein 569 0.60264
ZNF629 zinc finger protein 629 0.60264
ZNF501 zinc finger protein 501 0.60264
ZNF763 zinc finger protein 763 0.60264
SYNJ2BP synaptojanin 2 binding protein 0.60147
NANOS2 nanos homolog 2 (Drosophila) 0.60108
TBX3 T-box 3 0.60069
NPBWR1 neuropeptides B/W receptor 1 0.6003
DNTT DNA nucleotidylexotransferase 0.59952
PARP4 poly (ADP-ribose) polymerase family, member 4 0.594843
ESR2 estrogen receptor 2 (ER beta) 0.593674
ZNF44 zinc finger protein 44 0.58939
XG Xg blood group 0.583941
SSR4 signal sequence receptor, delta 0.583552
BICC1 BicC family RNA binding protein 1 0.576939
BCL6B B-cell CLL/lymphoma 6, member B 0.57305
EIF3M eukaryotic translation initiation factor 3, subunit M 0.571495
ATF7IP activating transcription factor 7 interacting protein 0.565666
TESC tescalcin 0.563723
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane) 0.560227
NR0B1 nuclear receptor subfamily 0, group B, member 1 0.559839
PLXNB3 plexin B3 0.55712
DMRT2 doublesex and mab-3 related transcription factor 2 0.556732
IHH indian hedgehog 0.556344
HOXA11 homeobox A11 0.555568
FLRT3 fibronectin leucine rich transmembrane protein 3 0.548971
PRDM9 PR domain containing 9 0.548195
SHROOM3 shroom family member 3 0.547032
PEX26 peroxisomal biogenesis factor 26 0.541992
DAZL deleted in azoospermia-like 0.534635
SNRPE small nuclear ribonucleoprotein polypeptide E 0.532701
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 0.513802
STRBP spermatid perinuclear RNA binding protein 0.509576
EGR4 early growth response 4 0.503058
LDOC1 leucine zipper, down-regulated in cancer 1 0.501909
HOMER2 homer scaffolding protein 2 0.499231
IFT122 intraflagellar transport 122 0.492359
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20 0.490454
ZFY zinc finger protein, Y-linked 0.489691
ZNF436 zinc finger protein 436 0.489691
FBXW8 F-box and WD repeat domain containing 8 0.487788
NALCN sodium leak channel, non selective 0.487027
METAP2 methionyl aminopeptidase 2 0.479427
SPAG5 sperm associated antigen 5 0.476393
PAX6 paired box 6 0.476393
GSC2 goosecoid homeobox 2 0.471846
MCM8 minichromosome maintenance complex component 8 0.46655
SALL1 spalt-like transcription factor 1 0.46655
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.459373
PRKG2 protein kinase, cGMP-dependent, type II 0.455224
MAP2K1 mitogen-activated protein kinase kinase 1 0.453339
SOX3 SRY (sex determining region Y)-box 3 0.448441
FGF8 fibroblast growth factor 8 (androgen-induced) 0.445429
CDY1 chromodomain protein, Y-linked, 1 0.437154
DGCR2 DiGeorge syndrome critical region gene 2 0.436778
POMC proopiomelanocortin 0.430768
HIPK3 homeodomain interacting protein kinase 3 0.42589
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 0.425139
PSG5 pregnancy specific beta-1-glycoprotein 5 0.424014
HS6ST1 heparan sulfate 6-O-sulfotransferase 1 0.418394
HRAS Harvey rat sarcoma viral oncogene homolog 0.415773
NAA10 N(alpha)-acetyltransferase 10, NatA catalytic subunit 0.413153
SMOC1 SPARC related modular calcium binding 1 0.412031
ZFP57 ZFP57 zinc finger protein 0.410909
DNM3 dynamin 3 0.410161
CRYM crystallin, mu 0.408292
CHRNG cholinergic receptor, nicotinic, gamma (muscle) 0.405678
LAX1 lymphocyte transmembrane adaptor 1 0.404557
ALDH18A1 aldehyde dehydrogenase 18 family, member A1 0.398216
UTF1 undifferentiated embryonic cell transcription factor 1 0.397471
SOX9 SRY (sex determining region Y)-box 9 0.389653
FGF19 fibroblast growth factor 19 0.385193
BCAP31 B-cell receptor-associated protein 31 0.380368
STRA8 stimulated by retinoic acid 8 0.370368
PTGDS prostaglandin D2 synthase 21kDa (brain) 0.365562
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 0.360026
ERH enhancer of rudimentary homolog (Drosophila) 0.353395
PROP1 PROP paired-like homeobox 1 0.351555
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) 0.35082
TMEM70 transmembrane protein 70 0.350084
IGF1 insulin-like growth factor 1 (somatomedin C) 0.348981
AKAP5 A kinase (PRKA) anchor protein 5 0.348246
EBP emopamil binding protein (sterol isomerase) 0.344207
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.34384
KANK1 KN motif and ankyrin repeat domains 1 0.342372
RXRG retinoid X receptor, gamma 0.340173
RBM3 RNA binding motif (RNP1, RRM) protein 3 0.338341
BBS9 Bardet-Biedl syndrome 9 0.335778
BAX BCL2-associated X protein 0.331391
CDY1B chromodomain protein, Y-linked, 1B 0.328105
ERCC8 excision repair cross-complementation group 8 0.326281
RBM10 RNA binding motif protein 10 0.325552
ARSI arylsulfatase family, member I 0.324823
SRSF5 serine/arginine-rich splicing factor 5 0.320817
ZKSCAN7 zinc finger with KRAB and SCAN domains 7 0.315366
HSPH1 heat shock 105kDa/110kDa protein 1 0.311377
ZIC3 Zic family member 3 0.311014
RXRB retinoid X receptor, beta 0.30848
FZD10 frizzled class receptor 10 0.30848
UCKL1 uridine-cytidine kinase 1-like 1 0.307757
ALPP alkaline phosphatase, placental 0.305948
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor 0.304864
UCK1 uridine-cytidine kinase 1 0.301254
OCRL oculocerebrorenal syndrome of Lowe 0.299092
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.295492
FGF17 fibroblast growth factor 17 0.291898
DAAM1 dishevelled associated activator of morphogenesis 1 0.291539
HSF2 heat shock transcription factor 2 0.287952
OTX1 orthodenticle homeobox 1 0.286877
ACTN1 actinin, alpha 1 0.28294
TTC8 tetratricopeptide repeat domain 8 0.282225
PRL prolactin 0.279724
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.277227
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma 0.27687
ADM2 adrenomedullin 2 0.275801
PDZD4 PDZ domain containing 4 0.275445
ARID4A AT rich interactive domain 4A (RBP1-like) 0.274376
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.272953
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.272953
ADCY4 adenylate cyclase 4 0.272597
SHFM1 split hand/foot malformation (ectrodactyly) type 1 0.272597
MAX MYC associated factor X 0.271886
KRT18 keratin 18, type I 0.269753
BBS12 Bardet-Biedl syndrome 12 0.267977
NCOR2 nuclear receptor corepressor 2 0.266913
NCR3 natural cytotoxicity triggering receptor 3 0.266558
RPS17 ribosomal protein S17 0.265849
ALPPL2 alkaline phosphatase, placental-like 2 0.264431
BBS10 Bardet-Biedl syndrome 10 0.264077
ALPL alkaline phosphatase, liver/bone/kidney 0.263368
RAB23 RAB23, member RAS oncogene family 0.262306
GRB2 growth factor receptor-bound protein 2 0.260184
BBS7 Bardet-Biedl syndrome 7 0.259124
PFAS phosphoribosylformylglycinamidine synthase 0.25877
CNTN1 contactin 1 0.257711
MYH2 myosin, heavy chain 2, skeletal muscle, adult 0.257005
UCK2 uridine-cytidine kinase 2 0.253479
ADCY7 adenylate cyclase 7 0.253127
MSX2 msh homeobox 2 0.251366
SORD sorbitol dehydrogenase 0.248554
KITLG KIT ligand 0.246448
HIRA histone cell cycle regulator 0.245396
MEMO1 mediator of cell motility 1 0.243295
HOXA9 homeobox A9 0.242595
BBS5 Bardet-Biedl syndrome 5 0.239799
MIER1 mesoderm induction early response 1, transcriptional regulator 0.238752
MYH7 myosin, heavy chain 7, cardiac muscle, beta 0.227297
EMX2 empty spiracles homeobox 2 0.226262
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 0.226262
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1 0.225573
CHRND cholinergic receptor, nicotinic, delta (muscle) 0.222136
TSPO translocator protein (18kDa) 0.220424
SPTB spectrin, beta, erythrocytic 0.21974
HOXA13 homeobox A13 0.216672
IGFBP3 insulin-like growth factor binding protein 3 0.214636
MNX1 motor neuron and pancreas homeobox 1 0.212945
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3 0.211597
BMP3 bone morphogenetic protein 3 0.208914
ADCY1 adenylate cyclase 1 (brain) 0.207912
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 0.207578
PEX1 peroxisomal biogenesis factor 1 0.206913
ADCY3 adenylate cyclase 3 0.206248
PQBP1 polyglutamine binding protein 1 0.205585
PRM1 protamine 1 0.203275
PARG poly (ADP-ribose) glycohydrolase 0.201962
GFRA1 GDNF family receptor alpha 1 0.199033
SLC25A18 solute carrier family 25 (glutamate carrier), member 18 0.196459
HSD17B1P1 hydroxysteroid (17-beta) dehydrogenase 1 pseudogene 1 0.196459
PNMA2 paraneoplastic Ma antigen 2 0.196139
WNT5A wingless-type MMTV integration site family, member 5A 0.192031
CTNND2 catenin (cadherin-associated protein), delta 2 0.190476
DKKL1 dickkopf-like 1 0.188938
MMP11 matrix metallopeptidase 11 0.187415
ADCY10 adenylate cyclase 10 (soluble) 0.18621
CDT1 chromatin licensing and DNA replication factor 1 0.183541
ALX4 ALX homeobox 4 0.182957
AATF apoptosis antagonizing transcription factor 0.182666
FLNA filamin A, alpha 0.180367
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 0.176215
ATF3 activating transcription factor 3 0.173832
CPEB1 cytoplasmic polyadenylation element binding protein 1 0.172544
ADCY9 adenylate cyclase 9 0.170544
C1QBP complement component 1, q subcomponent binding protein 0.168617
GNPAT glyceronephosphate O-acyltransferase 0.168381
ADCY2 adenylate cyclase 2 (brain) 0.165435
UBR1 ubiquitin protein ligase E3 component n-recognin 1 0.165217
PRDX4 peroxiredoxin 4 0.164359
ADCY6 adenylate cyclase 6 0.164149
CSH2 chorionic somatomammotropin hormone 2 0.163317
DOK7 docking protein 7 0.163111
DIRAS3 DIRAS family, GTP-binding RAS-like 3 0.163111
G6PC3 glucose 6 phosphatase, catalytic, 3 0.163111
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.162707
ADCY5 adenylate cyclase 5 0.162505
INSC inscuteable homolog (Drosophila) 0.162109
TCOF1 Treacher Collins-Franceschetti syndrome 1 0.161523
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 0.160203
CREM cAMP responsive element modulator 0.15948
PLK4 polo-like kinase 4 0.15948