ctcf Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description CCCTC-binding factor (zinc finger protein)|This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010] (NCBI Entrez Gene Database, 10664)
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Genes

57 genes co-occuring with the biological term ctcf in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACTB actin, beta
BAX BCL2-associated X protein
BCL3 B-cell CLL/lymphoma 3
CBX5 chromobox homolog 5
CDKN2A cyclin-dependent kinase inhibitor 2A
CTAG1B cancer/testis antigen 1B
CTCF CCCTC-binding factor (zinc finger protein)
CTCFL CCCTC-binding factor (zinc finger protein)-like
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
EGF epidermal growth factor
EGFR epidermal growth factor receptor
ERCC4 excision repair cross-complementation group 4
ERCC5 excision repair cross-complementation group 5
FMR1 fragile X mental retardation 1
FXN frataxin
H19 H19, imprinted maternally expressed transcript (non-protein coding)
HBB hemoglobin, beta
HDLBP high density lipoprotein binding protein
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
IFNG interferon, gamma
IGF2 insulin-like growth factor 2
IGF2R insulin-like growth factor 2 receptor
IPO13 importin 13
IRAK2 interleukin-1 receptor-associated kinase 2
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5
LMNA lamin A/C
MIR34A microRNA 34a
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NIPBL Nipped-B homolog (Drosophila)
NNAT neuronatin
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
RAD21 RAD21 homolog (S. pombe)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RB1 retinoblastoma 1
RBL2 retinoblastoma-like 2
RUNX1 runt-related transcription factor 1
SIRT6 sirtuin 6
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
SPI1 Spi-1 proto-oncogene
SRA1 steroid receptor RNA activator 1
STAG1 stromal antigen 1
STAG2 stromal antigen 2
SUMO1 small ubiquitin-like modifier 1
SUMO2 small ubiquitin-like modifier 2
SUMO3 small ubiquitin-like modifier 3
TBX21 T-box 21
TERT telomerase reverse transcriptase
TP53 tumor protein p53
TSIX TSIX transcript, XIST antisense RNA
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)
ZBTB33 zinc finger and BTB domain containing 33
ZMYND10 zinc finger, MYND-type containing 10