ctla4 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description cytotoxic T-lymphocyte-associated protein 4|This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1493)
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Genes

67 genes co-occuring with the biological term ctla4 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ARF1 ADP-ribosylation factor 1
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CD14 CD14 molecule
CD1D CD1d molecule
CD274 CD274 molecule
CD28 CD28 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD52 CD52 molecule
CD80 CD80 molecule
CD86 CD86 molecule
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FOXP3 forkhead box P3
GATA3 GATA binding protein 3
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HAVCR2 hepatitis A virus cellular receptor 2
HLA-A major histocompatibility complex, class I, A
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-DRB3 major histocompatibility complex, class II, DR beta 3
HLA-DRB4 major histocompatibility complex, class II, DR beta 4
ICOS inducible T-cell co-stimulator
IDO1 indoleamine 2,3-dioxygenase 1
IFNA1 interferon, alpha 1
IFNB1 interferon, beta 1, fibroblast
IFNG interferon, gamma
IL10 interleukin 10
IL13 interleukin 13
IL13RA1 interleukin 13 receptor, alpha 1
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL21 interleukin 21
IL2RA interleukin 2 receptor, alpha
IL4R interleukin 4 receptor
IL7R interleukin 7 receptor
INS insulin
KLRK1 killer cell lectin-like receptor subfamily K, member 1
LAX1 lymphocyte transmembrane adaptor 1
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
MGAT1 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
MMEL1 membrane metallo-endopeptidase-like 1
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
PDCD1 programmed cell death 1
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
RAB8A RAB8A, member RAS oncogene family
RHOBTB2 Rho-related BTB domain containing 2
S100B S100 calcium binding protein B
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC38A8 solute carrier family 38, member 8
SLC4A2 solute carrier family 4 (anion exchanger), member 2
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT4 signal transducer and activator of transcription 4
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TG thyroglobulin
TGFB1 transforming growth factor, beta 1
TNF tumor necrosis factor
TNFRSF18 tumor necrosis factor receptor superfamily, member 18
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18
TP53 tumor protein p53
TPO thyroid peroxidase
TRAT1 T cell receptor associated transmembrane adaptor 1
WNT3 wingless-type MMTV integration site family, member 3
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa