ctnnb1 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description catenin (cadherin-associated protein), beta 1, 88kDa|The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Oct 2009] (NCBI Entrez Gene Database, 1499)
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Genes

50 genes co-occuring with the biological term ctnnb1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
AMACR alpha-methylacyl-CoA racemase
AMER1 APC membrane recruitment protein 1
APC adenomatous polyposis coli
AXIN1 axin 1
BCL6 B-cell CLL/lymphoma 6
BRAF B-Raf proto-oncogene, serine/threonine kinase
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
CASP4 caspase 4, apoptosis-related cysteine peptidase
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNNBIP1 catenin, beta interacting protein 1
EGFR epidermal growth factor receptor
FGF19 fibroblast growth factor 19
FGFR2 fibroblast growth factor receptor 2
GLI1 GLI family zinc finger 1
GPC3 glypican 3
GSK3B glycogen synthase kinase 3 beta
HESX1 HESX homeobox 1
HNF1A HNF1 homeobox A
HRAS Harvey rat sarcoma viral oncogene homolog
IGF2 insulin-like growth factor 2
IL6ST interleukin 6 signal transducer
KHSRP KH-type splicing regulatory protein
KRAS Kirsten rat sarcoma viral oncogene homolog
MIR150 microRNA 150
MIR200A microRNA 200a
MIR214 microRNA 214
MLH1 mutL homolog 1
NOTCH1 notch 1
NOTCH2 notch 2
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
POU1F1 POU class 1 homeobox 1
PROP1 PROP paired-like homeobox 1
PTEN phosphatase and tensin homolog
RET ret proto-oncogene
SFRP1 secreted frizzled-related protein 1
SLCO1B3 solute carrier organic anion transporter family, member 1B3
TERT telomerase reverse transcriptase
TP53 tumor protein p53
WNT1 wingless-type MMTV integration site family, member 1
WNT2B wingless-type MMTV integration site family, member 2B
WNT3A wingless-type MMTV integration site family, member 3A
WNT9B wingless-type MMTV integration site family, member 9B
WT1 Wilms tumor 1
ZEB2 zinc finger E-box binding homeobox 2
ZNF24 zinc finger protein 24