cullin-RING ubiquitin ligase complex Gene Set

Dataset GO Cellular Component Annotations 2025
Category structural or functional annotations
Type cellular component
Description Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity. (Gene Ontology, GO_0031461)
External Link http://amigo.geneontology.org/amigo/term/GO:0031461
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Genes

220 proteins localized to the cullin-RING ubiquitin ligase complex cellular component from the curated GO Cellular Component Annotations 2025 dataset.

Symbol Name
AMBRA1 autophagy/beclin-1 regulator 1
AMN1 antagonist of mitotic exit network 1 homolog (S. cerevisiae)
ANAPC1 anaphase promoting complex subunit 1
ANAPC10 anaphase promoting complex subunit 10
ANAPC11 anaphase promoting complex subunit 11
ANAPC13 anaphase promoting complex subunit 13
ANAPC15 anaphase promoting complex subunit 15
ANAPC16 anaphase promoting complex subunit 16
ANAPC2 anaphase promoting complex subunit 2
ANAPC4 anaphase promoting complex subunit 4
ANAPC5 anaphase promoting complex subunit 5
ANAPC7 anaphase promoting complex subunit 7
ANKRD9 ankyrin repeat domain 9
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2
ASB11 ankyrin repeat and SOCS box containing 11, E3 ubiquitin protein ligase
ASB4 ankyrin repeat and SOCS box containing 4
ASB9 ankyrin repeat and SOCS box containing 9
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CAND1 cullin-associated and neddylation-dissociated 1
CCIN calicin
CCNF cyclin F
CDC16 cell division cycle 16
CDC20 cell division cycle 20
CDC20B cell division cycle 20B
CDC23 cell division cycle 23
CDC26 cell division cycle 26
CDC27 cell division cycle 27
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
COMMD1 copper metabolism (Murr1) domain containing 1
CUL1 cullin 1
CUL2 cullin 2
CUL3 cullin 3
CUL4A cullin 4A
CUL4B cullin 4B
CUL5 cullin 5
CUL7 cullin 7
CUL9 cullin 9
DAW1 dynein assembly factor with WDR repeat domains 1
DCAF1 DDB1 and CUL4 associated factor 1
DCAF10 DDB1 and CUL4 associated factor 10
DCAF11 DDB1 and CUL4 associated factor 11
DCAF12 DDB1 and CUL4 associated factor 12
DCAF12L1 DDB1 and CUL4 associated factor 12-like 1
DCAF12L2 DDB1 and CUL4 associated factor 12-like 2
DCAF13 DDB1 and CUL4 associated factor 13
DCAF15 DDB1 and CUL4 associated factor 15
DCAF16 DDB1 and CUL4 associated factor 16
DCAF17 DDB1 and CUL4 associated factor 17
DCAF4 DDB1 and CUL4 associated factor 4
DCAF4L1 DDB1 and CUL4 associated factor 4-like 1
DCAF4L2 DDB1 and CUL4 associated factor 4-like 2
DCAF5 DDB1 and CUL4 associated factor 5
DCAF6 DDB1 and CUL4 associated factor 6
DCAF7 DDB1 and CUL4 associated factor 7
DCAF8 DDB1 and CUL4 associated factor 8
DCAF8L1 DDB1 and CUL4 associated factor 8-like 1
DCAF8L2 DDB1 and CUL4 associated factor 8-like 2
DDA1 DET1 and DDB1 associated 1
DDB1 damage-specific DNA binding protein 1, 127kDa
DDB2 damage-specific DNA binding protein 2, 48kDa
DEPDC5 DEP domain containing 5
DET1 de-etiolated homolog 1 (Arabidopsis)
DMAC2 distal membrane arm assembly component 2
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ELOB elongin B
ELOC elongin C
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ERCC8 excision repair cross-complementation group 8
FBH1 F-box DNA helicase 1
FBXL13 F-box and leucine-rich repeat protein 13
FBXL14 F-box and leucine-rich repeat protein 14
FBXL15 F-box and leucine-rich repeat protein 15
FBXL16 F-box and leucine-rich repeat protein 16
FBXL17 F-box and leucine-rich repeat protein 17
FBXL19 F-box and leucine-rich repeat protein 19
FBXL2 F-box and leucine-rich repeat protein 2
FBXL20 F-box and leucine-rich repeat protein 20
FBXL3 F-box and leucine-rich repeat protein 3
FBXL4 F-box and leucine-rich repeat protein 4
FBXL5 F-box and leucine-rich repeat protein 5
FBXL6 F-box and leucine-rich repeat protein 6
FBXL7 F-box and leucine-rich repeat protein 7
FBXO15 F-box protein 15
FBXO17 F-box protein 17
FBXO2 F-box protein 2
FBXO25 F-box protein 25
FBXO27 F-box protein 27
FBXO3 F-box protein 3
FBXO31 F-box protein 31
FBXO32 F-box protein 32
FBXO38 F-box protein 38
FBXO39 F-box protein 39
FBXO4 F-box protein 4
FBXO42 F-box protein 42
FBXO44 F-box protein 44
FBXO45 F-box protein 45
FBXO48 F-box protein 48
FBXO6 F-box protein 6
FBXO7 F-box protein 7
FBXO9 F-box protein 9
FBXW11 F-box and WD repeat domain containing 11
FBXW4 F-box and WD repeat domain containing 4
FBXW5 F-box and WD repeat domain containing 5
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FBXW8 F-box and WD repeat domain containing 8
FEM1B fem-1 homolog b (C. elegans)
FEM1C fem-1 homolog c (C. elegans)
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GAN gigaxonin
GLMN glomulin, FKBP associated protein
IPP intracisternal A particle-promoted polypeptide
IVNS1ABP influenza virus NS1A binding protein
KBTBD12 kelch repeat and BTB (POZ) domain containing 12
KBTBD2 kelch repeat and BTB (POZ) domain containing 2
KBTBD3 kelch repeat and BTB (POZ) domain containing 3
KBTBD6 kelch repeat and BTB (POZ) domain containing 6
KBTBD7 kelch repeat and BTB (POZ) domain containing 7
KBTBD8 kelch repeat and BTB (POZ) domain containing 8
KCTD10 potassium channel tetramerization domain containing 10
KCTD13 potassium channel tetramerization domain containing 13
KCTD17 potassium channel tetramerization domain containing 17
KCTD2 potassium channel tetramerization domain containing 2
KCTD5 potassium channel tetramerization domain containing 5
KEAP1 kelch-like ECH-associated protein 1
KLHDC1 kelch domain containing 1
KLHDC10 kelch domain containing 10
KLHDC2 kelch domain containing 2
KLHDC3 kelch domain containing 3
KLHL1 kelch-like family member 1
KLHL10 kelch-like family member 10
KLHL11 kelch-like family member 11
KLHL12 kelch-like family member 12
KLHL13 kelch-like family member 13
KLHL15 kelch-like family member 15
KLHL17 kelch-like family member 17
KLHL18 kelch-like family member 18
KLHL2 kelch-like family member 2
KLHL20 kelch-like family member 20
KLHL21 kelch-like family member 21
KLHL22 kelch-like family member 22
KLHL23 kelch-like family member 23
KLHL24 kelch-like family member 24
KLHL25 kelch-like family member 25
KLHL28 kelch-like family member 28
KLHL29 kelch-like family member 29
KLHL3 kelch-like family member 3
KLHL30 kelch-like family member 30
KLHL35 kelch-like family member 35
KLHL38 kelch-like family member 38
KLHL4 kelch-like family member 4
KLHL40 kelch-like family member 40
KLHL41 kelch-like family member 41
KLHL42 kelch-like family member 42
KLHL5 kelch-like family member 5
KLHL6 kelch-like family member 6
KLHL7 kelch-like family member 7
KLHL8 kelch-like family member 8
KLHL9 kelch-like family member 9
LRRC75A leucine rich repeat containing 75A
LZTR1 leucine-zipper-like transcription regulator 1
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast)
NCCRP1 non-specific cytotoxic cell receptor protein 1 homolog (zebrafish)
OTULIN-DT OTULIN divergent transcript
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1
PDCD6 programmed cell death 6
PEF1 penta-EF-hand domain containing 1
PRAME preferentially expressed antigen in melanoma
PRAMEF1 PRAME family member 1
PRAMEF10 PRAME family member 10
PRAMEF11 PRAME family member 11
PRAMEF12 PRAME family member 12
PRAMEF13 PRAME family member 13
PRAMEF14 PRAME family member 14
PRAMEF15 PRAME family member 15
PRAMEF17 PRAME family member 17
PRAMEF18 PRAME family member 18
PRAMEF19 PRAME family member 19
PRAMEF2 PRAME family member 2
PRAMEF20 PRAME family member 20
PRAMEF22 PRAME family member 22
PRAMEF26 PRAME family member 26
PRAMEF33 PRAME family member 33
PRAMEF4 PRAME family member 4
PRAMEF5 PRAME family member 5
PRAMEF6 PRAME family member 6
PRAMEF7 PRAME family member 7
PRAMEF8 PRAME family member 8
PRAMEF9 PRAME family member 9
PRKN parkin RBR E3 ubiquitin protein ligase
RBX1 ring-box 1, E3 ubiquitin protein ligase
RNF7 ring finger protein 7
SKP1 S-phase kinase-associated protein 1
SOCS2 suppressor of cytokine signaling 2
SOCS4 suppressor of cytokine signaling 4
SPOP speckle-type POZ protein
SPOPL speckle-type POZ protein-like
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
SPSB2 splA/ryanodine receptor domain and SOCS box containing 2
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
SPSB4 splA/ryanodine receptor domain and SOCS box containing 4
TMEM183A transmembrane protein 183A
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)
TRIM21 tripartite motif containing 21
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
USP47 ubiquitin specific peptidase 47
UXT ubiquitously-expressed, prefoldin-like chaperone
WDTC1 WD and tetratricopeptide repeats 1
ZER1 zyg-11 related, cell cycle regulator
ZSWIM4 zinc finger, SWIM-type containing 4
ZSWIM5 zinc finger, SWIM-type containing 5
ZSWIM6 zinc finger, SWIM-type containing 6
ZSWIM8 zinc finger, SWIM-type containing 8
ZYG11A zyg-11 family member A, cell cycle regulator
ZYG11B zyg-11 family member B, cell cycle regulator