cxcl12 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description chemokine (C-X-C motif) ligand 12|This antimicrobial gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. The encoded protein functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4, and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014] (NCBI Entrez Gene Database, 6387)
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Genes

110 genes co-occuring with the biological term cxcl12 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACKR3 atypical chemokine receptor 3
AKT1 v-akt murine thymoma viral oncogene homolog 1
ANO1 anoctamin 1, calcium activated chloride channel
AR androgen receptor
AREG amphiregulin
ARRB2 arrestin, beta 2
ATF3 activating transcription factor 3
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
C3 complement component 3
CCL17 chemokine (C-C motif) ligand 17
CCL19 chemokine (C-C motif) ligand 19
CCL2 chemokine (C-C motif) ligand 2
CCL27 chemokine (C-C motif) ligand 27
CCL5 chemokine (C-C motif) ligand 5
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD34 CD34 molecule
CD82 CD82 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CIITA class II, major histocompatibility complex, transactivator
COL1A1 collagen, type I, alpha 1
CTSB cathepsin B
CX3CL1 chemokine (C-X3-C motif) ligand 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR2 chemokine (C-X-C motif) receptor 2
CXCR3 chemokine (C-X-C motif) receptor 3
CXCR4 chemokine (C-X-C motif) receptor 4
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DPP4 dipeptidyl-peptidase 4
DPP8 dipeptidyl-peptidase 8
EGFR epidermal growth factor receptor
EPAS1 endothelial PAS domain protein 1
EPS8 epidermal growth factor receptor pathway substrate 8
ESR1 estrogen receptor 1
FLT3 fms-related tyrosine kinase 3
FOXM1 forkhead box M1
FOXP3 forkhead box P3
GATA2 GATA binding protein 2
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
HAVCR2 hepatitis A virus cellular receptor 2
HMGB1 high mobility group box 1
HRH4 histamine receptor H4
ICAM1 intercellular adhesion molecule 1
IFNG interferon, gamma
IL18 interleukin 18
IRF8 interferon regulatory factor 8
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITK IL2-inducible T-cell kinase
JAK2 Janus kinase 2
JAK3 Janus kinase 3
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LRP1 low density lipoprotein receptor-related protein 1
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MARCO macrophage receptor with collagenous structure
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MMP13 matrix metallopeptidase 13
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP9 matrix metallopeptidase 9
MYD88 myeloid differentiation primary response 88
NCOA1 nuclear receptor coactivator 1
NCOA2 nuclear receptor coactivator 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NGF nerve growth factor (beta polypeptide)
NGFR nerve growth factor receptor
NOS2 nitric oxide synthase 2, inducible
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NR2F1 nuclear receptor subfamily 2, group F, member 1
PF4 platelet factor 4
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PTEN phosphatase and tensin homolog
RACGAP1 Rac GTPase activating protein 1
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
SDC4 syndecan 4
SH2D2A SH2 domain containing 2A
SNAI2 snail family zinc finger 2
THBS1 thrombospondin 1
THOC5 THO complex 5
TICAM2 toll-like receptor adaptor molecule 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TP53 tumor protein p53
TPBG trophoblast glycoprotein
VAV1 vav 1 guanine nucleotide exchange factor
VEGFA vascular endothelial growth factor A
VTRNA2-1 vault RNA 2-1
WAS Wiskott-Aldrich syndrome
WWP1 WW domain containing E3 ubiquitin protein ligase 1
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa