cxcr4 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description chemokine (C-X-C motif) receptor 4|This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7852)
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Genes

238 genes co-occuring with the biological term cxcr4 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACKR3 atypical chemokine receptor 3
ADRB2 adrenoceptor beta 2, surface
ADRBK1 adrenergic, beta, receptor kinase 1
ADRBK2 adrenergic, beta, receptor kinase 2
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALOX15 arachidonate 15-lipoxygenase
AR androgen receptor
ARRB1 arrestin, beta 1
ARRB2 arrestin, beta 2
ATM ATM serine/threonine kinase
BAK1 BCL2-antagonist/killer 1
BCL10 B-cell CLL/lymphoma 10
BCL2L1 BCL2-like 1
BMP4 bone morphogenetic protein 4
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
BRMS1 breast cancer metastasis suppressor 1
C4ORF32 chromosome 4 open reading frame 32
CA9 carbonic anhydrase IX
CARD10 caspase recruitment domain family, member 10
CAV1 caveolin 1, caveolae protein, 22kDa
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCL5 chemokine (C-C motif) ligand 5
CCR1 chemokine (C-C motif) receptor 1
CCR2 chemokine (C-C motif) receptor 2
CCR3 chemokine (C-C motif) receptor 3
CCR4 chemokine (C-C motif) receptor 4
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR6 chemokine (C-C motif) receptor 6
CCR7 chemokine (C-C motif) receptor 7
CD14 CD14 molecule
CD164 CD164 molecule, sialomucin
CD34 CD34 molecule
CD4 CD4 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD44 CD44 molecule (Indian blood group)
CD63 CD63 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEL carboxyl ester lipase
CFL1 cofilin 1 (non-muscle)
CMKLR1 chemerin chemokine-like receptor 1
COL1A2 collagen, type I, alpha 2
CR2 complement component (3d/Epstein Barr virus) receptor 2
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTTN cortactin
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR1 chemokine (C-X-C motif) receptor 1
CXCR2 chemokine (C-X-C motif) receptor 2
CXCR3 chemokine (C-X-C motif) receptor 3
CXCR4 chemokine (C-X-C motif) receptor 4
DEFB103A defensin, beta 103A
DEFB103B defensin, beta 103B
DNAJC14 DnaJ (Hsp40) homolog, subfamily C, member 14
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DOCK1 dedicator of cytokinesis 1
DTX3L deltex 3 like, E3 ubiquitin ligase
EDNRA endothelin receptor type A
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EPAS1 endothelial PAS domain protein 1
ERBB2 erb-b2 receptor tyrosine kinase 2
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ESR1 estrogen receptor 1
ETV4 ets variant 4
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FLT1 fms-related tyrosine kinase 1
FLT3 fms-related tyrosine kinase 3
FLT4 fms-related tyrosine kinase 4
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXA2 forkhead box A2
FOXC1 forkhead box C1
FOXC2 forkhead box C2
FOXO1 forkhead box O1
FOXP3 forkhead box P3
GLI1 GLI family zinc finger 1
GLIPR1 GLI pathogenesis-related 1
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GRK5 G protein-coupled receptor kinase 5
GRK6 G protein-coupled receptor kinase 6
GSTP1 glutathione S-transferase pi 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HHEX hematopoietically expressed homeobox
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HMGB1 high mobility group box 1
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
IFNA1 interferon, alpha 1
IFNG interferon, gamma
IGF1R insulin-like growth factor 1 receptor
IGF2 insulin-like growth factor 2
IL13 interleukin 13
IL18 interleukin 18
IL2 interleukin 2
IL4 interleukin 4
IL6 interleukin 6
IL7 interleukin 7
IL7R interleukin 7 receptor
ITCH itchy E3 ubiquitin protein ligase
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JAK2 Janus kinase 2
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KDR kinase insert domain receptor
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLF2 Kruppel-like factor 2
KRT19 keratin 19, type I
LIF leukemia inhibitory factor
LIMK1 LIM domain kinase 1
LYN LYN proto-oncogene, Src family tyrosine kinase
MALT1 MALT1 paracaspase
MAML2 mastermind-like 2 (Drosophila)
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MET MET proto-oncogene, receptor tyrosine kinase
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MIR126 microRNA 126
MIR133B microRNA 133b
MIR137 microRNA 137
MIR139 microRNA 139
MIR146A microRNA 146a
MIR150 microRNA 150
MIR302A microRNA 302a
MIR367 microRNA 367
MIR494 microRNA 494
MIR9-1 microRNA 9-1
MIR9-2 microRNA 9-2
MIR9-3 microRNA 9-3
MLH1 mutL homolog 1
MMP1 matrix metallopeptidase 1
MMP13 matrix metallopeptidase 13
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MSH2 mutS homolog 2
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYD88 myeloid differentiation primary response 88
MYH9 myosin, heavy chain 9, non-muscle
NANOG Nanog homeobox
NEUROG3 neurogenin 3
NEWENTRY Record to support submission of GeneRIFs for a gene not in Gene (human; man).
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR3C2 nuclear receptor subfamily 3, group C, member 2
NRP2 neuropilin 2
NUCLEOLIN nucleolin multifunctional protein
OPRD1 opioid receptor, delta 1
OPRK1 opioid receptor, kappa 1
OPRL1 opiate receptor-like 1
PAX3 paired box 3
PDGFB platelet-derived growth factor beta polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PF4 platelet factor 4
PGK1 phosphoglycerate kinase 1
PLAUR plasminogen activator, urokinase receptor
PLEC plectin
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PRKCA protein kinase C, alpha
PRKCZ protein kinase C, zeta
PROM1 prominin 1
PTEN phosphatase and tensin homolog
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK2 protein tyrosine kinase 2
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RHOD ras homolog family member D
RND3 Rho family GTPase 3
RPL21P7 ribosomal protein L21 pseudogene 7
S100A4 S100 calcium binding protein A4
SELL selectin L
SGK3 serum/glucocorticoid regulated kinase family, member 3
SHH sonic hedgehog
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SLIT1 slit homolog 1 (Drosophila)
SLIT2 slit homolog 2 (Drosophila)
SLIT3 slit homolog 3 (Drosophila)
SMAD7 SMAD family member 7
SNF8 SNF8, ESCRT-II complex subunit
SRC SRC proto-oncogene, non-receptor tyrosine kinase
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
STAMBP STAM binding protein
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TCF4 transcription factor 4
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TERT telomerase reverse transcriptase
TFF2 trefoil factor 2
TGFA transforming growth factor, alpha
TGFB1 transforming growth factor, beta 1
THADA thyroid adenoma associated
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TLR7 toll-like receptor 7
TNF tumor necrosis factor
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TP53 tumor protein p53
TPBG trophoblast glycoprotein
TPST1 tyrosylprotein sulfotransferase 1
TSC2 tuberous sclerosis 2
TWIST1 twist family bHLH transcription factor 1
UBE2I ubiquitin-conjugating enzyme E2I
USP8 ubiquitin specific peptidase 8
VAV1 vav 1 guanine nucleotide exchange factor
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
VEGFC vascular endothelial growth factor C
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
WNT5A wingless-type MMTV integration site family, member 5A
WWP1 WW domain containing E3 ubiquitin protein ligase 1
YY1 YY1 transcription factor
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZBTB16 zinc finger and BTB domain containing 16
ZG16B zymogen granule protein 16B