cyclin-dependent protein kinase activating kinase holoenzyme complex Gene Set

Dataset GO Cellular Component Annotations
Category structural or functional annotations
Type cellular component
Description A cyclin-dependent kinase activating kinase complex capable of activating cyclin-dependent kinases by threonine phosphorylation, thus regulating cell cycle progression. consists of a kinase, cyclin and optional assembly factors, in human CDK7, CCNH and MNAT1. CAK activity is itself regulated throughout the cell cycle by T-loop phosphorylation of its kinase component (CDK7 in human). Phosphorylation of serine residues during mitosis inactivates the enzyme. Also capable of CAK phosphorylating the carboxyl-terminal domain (CTD) of RNA polymerase II and other transcription activating proteins, as part of the general transcription factor TFIIH. (Gene Ontology, GO_0019907)
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6 proteins localized to the cyclin-dependent protein kinase activating kinase holoenzyme complex cellular component from the curated GO Cellular Component Annotations dataset.

Symbol Name
CCNH cyclin H
ERCC2 excision repair cross-complementation group 2
HOXC10 homeobox C10
HSPD1 heat shock 60kDa protein 1 (chaperonin)
KDM5A lysine (K)-specific demethylase 5A
PUF60 poly-U binding splicing factor 60KDa