| Dataset | GO Cellular Component Annotations 2015 |
| Category | structural or functional annotations |
| Type | cellular component |
| Description | A cyclin-dependent kinase activating kinase complex capable of activating cyclin-dependent kinases by threonine phosphorylation, thus regulating cell cycle progression. consists of a kinase, cyclin and optional assembly factors, in human CDK7, CCNH and MNAT1. CAK activity is itself regulated throughout the cell cycle by T-loop phosphorylation of its kinase component (CDK7 in human). Phosphorylation of serine residues during mitosis inactivates the enzyme. Also capable of CAK phosphorylating the carboxyl-terminal domain (CTD) of RNA polymerase II and other transcription activating proteins, as part of the general transcription factor TFIIH. (Gene Ontology, GO_0019907) |
| External Link | http://amigo.geneontology.org/amigo/term/GO:0019907 |
| Similar Terms | |
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6 proteins localized to the cyclin-dependent protein kinase activating kinase holoenzyme complex cellular component from the curated GO Cellular Component Annotations 2015 dataset.
