cyclizine-5100 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the cyclizine-5100 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AIM1L absent in melanoma 1-like
ALPPL2 alkaline phosphatase, placental-like 2
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3
ATF7IP activating transcription factor 7 interacting protein
BMP8B bone morphogenetic protein 8b
BTBD7 BTB (POZ) domain containing 7
C16ORF59 chromosome 16 open reading frame 59
C1S complement component 1, s subcomponent
CA5B carbonic anhydrase VB, mitochondrial
CA9 carbonic anhydrase IX
CCNO cyclin O
CDK13 cyclin-dependent kinase 13
CREB3L1 cAMP responsive element binding protein 3-like 1
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
DCAF11 DDB1 and CUL4 associated factor 11
DCHS2 dachsous cadherin-related 2
DDN dendrin
DENND2A DENN/MADD domain containing 2A
DHODH dihydroorotate dehydrogenase (quinone)
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5
EDC3 enhancer of mRNA decapping 3
EGLN2 egl-9 family hypoxia-inducible factor 2
ERMAP erythroblast membrane-associated protein (Scianna blood group)
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM46C family with sequence similarity 46, member C
FGF1 fibroblast growth factor 1 (acidic)
GAL3ST4 galactose-3-O-sulfotransferase 4
GPR182 G protein-coupled receptor 182
GRM8 glutamate receptor, metabotropic 8
GRTP1 growth hormone regulated TBC protein 1
GTF2H2B general transcription factor IIH, polypeptide 2B (pseudogene)
HCFC1 host cell factor C1
HCRP1 hepatocellular carcinoma-related HCRP1
HIPK3 homeodomain interacting protein kinase 3
HIST2H2AA3 histone cluster 2, H2aa3
HOOK1 hook microtubule-tethering protein 1
HOXB5 homeobox B5
INF2 inverted formin, FH2 and WH2 domain containing
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
KLHL22 kelch-like family member 22
KRT8P12 keratin 8 pseudogene 12
LARP7 La ribonucleoprotein domain family, member 7
LAT2 linker for activation of T cells family, member 2
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LOXL2 lysyl oxidase-like 2
LRP1 low density lipoprotein receptor-related protein 1
LRRC15 leucine rich repeat containing 15
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MYO1D myosin ID
MYO1F myosin IF
MYOF myoferlin
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NUP50 nucleoporin 50kDa
OSBPL10 oxysterol binding protein-like 10
PCYT1B phosphate cytidylyltransferase 1, choline, beta
PDE4DIP phosphodiesterase 4D interacting protein
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PROSER1 proline and serine rich 1
PTPRF protein tyrosine phosphatase, receptor type, F
PTPRU protein tyrosine phosphatase, receptor type, U
RAB11FIP3 RAB11 family interacting protein 3 (class II)
RABGAP1 RAB GTPase activating protein 1
RARG retinoic acid receptor, gamma
RBBP9 retinoblastoma binding protein 9
REG1A regenerating islet-derived 1 alpha
REPS1 RALBP1 associated Eps domain containing 1
RUNX1-IT1 RUNX1 intronic transcript 1
SATB2 SATB homeobox 2
SIGLEC6 sialic acid binding Ig-like lectin 6
SIGMAR1 sigma non-opioid intracellular receptor 1
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
STRN striatin, calmodulin binding protein
SUN1 Sad1 and UNC84 domain containing 1
TAOK1 TAO kinase 1
TFDP3 transcription factor Dp family, member 3
TLN2 talin 2
TMEM231 transmembrane protein 231
TMEM63A transmembrane protein 63A
TOM1 target of myb1 (chicken)
TRA2A transformer 2 alpha homolog (Drosophila)
TTC30A tetratricopeptide repeat domain 30A
TTC39A tetratricopeptide repeat domain 39A
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
VPS9D1 VPS9 domain containing 1
WAS Wiskott-Aldrich syndrome
WSB1 WD repeat and SOCS box containing 1
XYLB xylulokinase homolog (H. influenzae)
XYLT2 xylosyltransferase II
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
ZBTB14 zinc finger and BTB domain containing 14
ZC3H7B zinc finger CCCH-type containing 7B
ZFP36L2 ZFP36 ring finger protein-like 2
ZFP64 ZFP64 zinc finger protein
ZNF268 zinc finger protein 268
ZNF695 zinc finger protein 695
ZSCAN32 zinc finger and SCAN domain containing 32

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ABHD8 abhydrolase domain containing 8
ACAD10 acyl-CoA dehydrogenase family, member 10
ACADSB acyl-CoA dehydrogenase, short/branched chain
ALS2CL ALS2 C-terminal like
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATAD5 ATPase family, AAA domain containing 5
BEND5 BEN domain containing 5
C14ORF105 chromosome 14 open reading frame 105
C1ORF159 chromosome 1 open reading frame 159
C6ORF47 chromosome 6 open reading frame 47
CCDC85C coiled-coil domain containing 85C
CCP110 centriolar coiled coil protein 110kDa
CDADC1 cytidine and dCMP deaminase domain containing 1
CEMIP cell migration inducing protein, hyaluronan binding
CFAP45 cilia and flagella associated protein 45
CGREF1 cell growth regulator with EF-hand domain 1
CLCN2 chloride channel, voltage-sensitive 2
CLCN6 chloride channel, voltage-sensitive 6
CNKSR1 connector enhancer of kinase suppressor of Ras 1
CPED1 cadherin-like and PC-esterase domain containing 1
CSF1R colony stimulating factor 1 receptor
DCLRE1B DNA cross-link repair 1B
DNAL4 dynein, axonemal, light chain 4
EDIL3 EGF-like repeats and discoidin I-like domains 3
EGF epidermal growth factor
FAM186A family with sequence similarity 186, member A
FANCC Fanconi anemia, complementation group C
FMO4 flavin containing monooxygenase 4
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GPRIN2 G protein regulated inducer of neurite outgrowth 2
HINFP histone H4 transcription factor
HIST1H2AI histone cluster 1, H2ai
HIST1H3C histone cluster 1, H3c
HOXA4 homeobox A4
HOXC10 homeobox C10
IFNA2 interferon, alpha 2
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IL22 interleukin 22
LAX1 lymphocyte transmembrane adaptor 1
LIN7B lin-7 homolog B (C. elegans)
LRP5L low density lipoprotein receptor-related protein 5-like
LRRK1 leucine-rich repeat kinase 1
MAST3 microtubule associated serine/threonine kinase 3
MCC mutated in colorectal cancers
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MRPS18C mitochondrial ribosomal protein S18C
MTHFSD methenyltetrahydrofolate synthetase domain containing
MXRA8 matrix-remodelling associated 8
MYH15 myosin, heavy chain 15
NACA2 nascent polypeptide-associated complex alpha subunit 2
NFIX nuclear factor I/X (CCAAT-binding transcription factor)
NIPAL2 NIPA-like domain containing 2
NME3 NME/NM23 nucleoside diphosphate kinase 3
NT5M 5',3'-nucleotidase, mitochondrial
NTF3 neurotrophin 3
OR1G1 olfactory receptor, family 1, subfamily G, member 1
OSBP2 oxysterol binding protein 2
OSR2 odd-skipped related transciption factor 2
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PHF14 PHD finger protein 14
PRICKLE3 prickle homolog 3 (Drosophila)
QSER1 glutamine and serine rich 1
RAB3A RAB3A, member RAS oncogene family
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS17 regulator of G-protein signaling 17
RNF2 ring finger protein 2
RPL13P5 ribosomal protein L13 pseudogene 5
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
SCGB2A2 secretoglobin, family 2A, member 2
SCUBE3 signal peptide, CUB domain, EGF-like 3
SDC3 syndecan 3
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SENP7 SUMO1/sentrin specific peptidase 7
SIRAL2 SIR2 antiphage like 2
SLC35F6 solute carrier family 35, member F6
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SPTBN2 spectrin, beta, non-erythrocytic 2
SRD5A3 steroid 5 alpha-reductase 3
STEAP4 STEAP family member 4
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
TMEM132A transmembrane protein 132A
TMEM51 transmembrane protein 51
USP19 ubiquitin specific peptidase 19
USP27X ubiquitin specific peptidase 27, X-linked
VWA1 von Willebrand factor A domain containing 1
YPEL1 yippee-like 1 (Drosophila)
ZBTB33 zinc finger and BTB domain containing 33
ZBTB6 zinc finger and BTB domain containing 6
ZNF177 zinc finger protein 177
ZNF225 zinc finger protein 225
ZNF93 zinc finger protein 93