cyclizine-5525 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the cyclizine-5525 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ACTR5 ARP5 actin-related protein 5 homolog (yeast)
ADAM20 ADAM metallopeptidase domain 20
ADCY6 adenylate cyclase 6
AFAP1 actin filament associated protein 1
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ARR3 arrestin 3, retinal (X-arrestin)
ATG10 autophagy related 10
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCL3 B-cell CLL/lymphoma 3
BIN1 bridging integrator 1
C1ORF159 chromosome 1 open reading frame 159
C2ORF44 chromosome 2 open reading frame 44
C7ORF69 chromosome 7 open reading frame 69
CALML4 calmodulin-like 4
CARD14 caspase recruitment domain family, member 14
CCDC71 coiled-coil domain containing 71
CCR7 chemokine (C-C motif) receptor 7
CD300A CD300a molecule
CD53 CD53 molecule
CD79B CD79b molecule, immunoglobulin-associated beta
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CEP164 centrosomal protein 164kDa
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
COL4A2 collagen, type IV, alpha 2
CYP2A7 cytochrome P450, family 2, subfamily A, polypeptide 7
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DLGAP4 discs, large (Drosophila) homolog-associated protein 4
DPF1 D4, zinc and double PHD fingers family 1
DPY19L1P1 DPY19L1 pseudogene 1
EDIL3 EGF-like repeats and discoidin I-like domains 3
EPOR erythropoietin receptor
FAM46C family with sequence similarity 46, member C
FLOT1 flotillin 1
GAB1 GRB2-associated binding protein 1
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GK glycerol kinase
GTDC1 glycosyltransferase-like domain containing 1
HLA-J major histocompatibility complex, class I, J (pseudogene)
HP1BP3 heterochromatin protein 1, binding protein 3
HRH4 histamine receptor H4
IFT38 intraflagellar transport 38
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
KAZN kazrin, periplakin interacting protein
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MARK2 MAP/microtubule affinity-regulating kinase 2
MAX MYC associated factor X
MED12 mediator complex subunit 12
MUC8 mucin 8
NCAN neurocan
NR0B2 nuclear receptor subfamily 0, group B, member 2
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PLXNB1 plexin B1
POFUT1 protein O-fucosyltransferase 1
PON1 paraoxonase 1
PORCN porcupine homolog (Drosophila)
PQLC2 PQ loop repeat containing 2
PRB1 proline-rich protein BstNI subfamily 1
PRKX protein kinase, X-linked
PTDSS2 phosphatidylserine synthase 2
QKI QKI, KH domain containing, RNA binding
RAB35 RAB35, member RAS oncogene family
RANBP10 RAN binding protein 10
RPL7 ribosomal protein L7
RPS4Y1 ribosomal protein S4, Y-linked 1
RUFY3 RUN and FYVE domain containing 3
SCARA3 scavenger receptor class A, member 3
SECTM1 secreted and transmembrane 1
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SIGLEC15 sialic acid binding Ig-like lectin 15
SIRT3 sirtuin 3
SIRT5 sirtuin 5
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SNPH syntaphilin
SOGA1 suppressor of glucose, autophagy associated 1
SP1 Sp1 transcription factor
TBC1D22A TBC1 domain family, member 22A
TBCD tubulin folding cofactor D
TGM2 transglutaminase 2
TRPC3 transient receptor potential cation channel, subfamily C, member 3
TTLL3 tubulin tyrosine ligase-like family member 3
USP2 ubiquitin specific peptidase 2
WIPI1 WD repeat domain, phosphoinositide interacting 1
WNT16 wingless-type MMTV integration site family, member 16
WWP2 WW domain containing E3 ubiquitin protein ligase 2
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZFPL1 zinc finger protein-like 1
ZNF324 zinc finger protein 324
ZNF639 zinc finger protein 639
ZNF778 zinc finger protein 778
ZSCAN32 zinc finger and SCAN domain containing 32
ZYX zyxin

decreased expression

Symbol Name
AARSD1 alanyl-tRNA synthetase domain containing 1
ACAD8 acyl-CoA dehydrogenase family, member 8
ACIN1 apoptotic chromatin condensation inducer 1
ACVR1 activin A receptor, type I
ACYP2 acylphosphatase 2, muscle type
AKAP12 A kinase (PRKA) anchor protein 12
ARHGAP5 Rho GTPase activating protein 5
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BIRC7 baculoviral IAP repeat containing 7
C22ORF29 chromosome 22 open reading frame 29
CBX4 chromobox homolog 4
CCNE1 cyclin E1
CDON cell adhesion associated, oncogene regulated
CHKB choline kinase beta
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CNKSR1 connector enhancer of kinase suppressor of Ras 1
COL4A5 collagen, type IV, alpha 5
CXADR coxsackie virus and adenovirus receptor
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DCAF17 DDB1 and CUL4 associated factor 17
DHRS3 dehydrogenase/reductase (SDR family) member 3
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DUSP5 dual specificity phosphatase 5
ELSPBP1 epididymal sperm binding protein 1
ERMAP erythroblast membrane-associated protein (Scianna blood group)
EXOC5 exocyst complex component 5
FBRS fibrosin
FCHSD2 FCH and double SH3 domains 2
FGD6 FYVE, RhoGEF and PH domain containing 6
FILIP1L filamin A interacting protein 1-like
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GNL1 guanine nucleotide binding protein-like 1
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4
HIST1H1D histone cluster 1, H1d
HOXC10 homeobox C10
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
HSPA1L heat shock 70kDa protein 1-like
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KCTD7 potassium channel tetramerization domain containing 7
KREMEN2 kringle containing transmembrane protein 2
LAMA5 laminin, alpha 5
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIN7B lin-7 homolog B (C. elegans)
LMO2 LIM domain only 2 (rhombotin-like 1)
LOC100286895 cell division cycle 27 homolog pseudogene
LRP2 low density lipoprotein receptor-related protein 2
LRP5L low density lipoprotein receptor-related protein 5-like
LRRC20 leucine rich repeat containing 20
LY6D lymphocyte antigen 6 complex, locus D
LYPD1 LY6/PLAUR domain containing 1
LZTR1 leucine-zipper-like transcription regulator 1
MAMLD1 mastermind-like domain containing 1
MBIP MAP3K12 binding inhibitory protein 1
MBTD1 mbt domain containing 1
MFSD11 major facilitator superfamily domain containing 11
MGC12488
MSI1 musashi RNA-binding protein 1
MUL1 mitochondrial E3 ubiquitin protein ligase 1
NOL10 nucleolar protein 10
NUBPL nucleotide binding protein-like
PACS1 phosphofurin acidic cluster sorting protein 1
PCNXL4 pecanex-like 4 (Drosophila)
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PLEKHA6 pleckstrin homology domain containing, family A member 6
PLEKHO1 pleckstrin homology domain containing, family O member 1
POLR1B polymerase (RNA) I polypeptide B, 128kDa
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1
PTK6 protein tyrosine kinase 6
PVRL3 poliovirus receptor-related 3
QPCT glutaminyl-peptide cyclotransferase
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RIBC2 RIB43A domain with coiled-coils 2
SCAI suppressor of cancer cell invasion
SCGB2A2 secretoglobin, family 2A, member 2
SCN1B sodium channel, voltage gated, type I beta subunit
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae)
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SLC46A3 solute carrier family 46, member 3
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SPIDR scaffolding protein involved in DNA repair
STAG3L4 stromal antigen 3-like 4 (pseudogene)
TMEM242 transmembrane protein 242
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TPST2 tyrosylprotein sulfotransferase 2
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
WDR18 WD repeat domain 18
XKR8 XK, Kell blood group complex subunit-related family, member 8
ZBED1 zinc finger, BED-type containing 1
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZNF219 zinc finger protein 219