cyclopenthiazide-2905 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the cyclopenthiazide-2905 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ACTN2 actinin, alpha 2
ADAM22 ADAM metallopeptidase domain 22
APOM apolipoprotein M
ARHGAP26 Rho GTPase activating protein 26
ARMC6 armadillo repeat containing 6
ATAT1 alpha tubulin acetyltransferase 1
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
AXIN1 axin 1
BCAS3 breast carcinoma amplified sequence 3
BIN1 bridging integrator 1
BTN2A2 butyrophilin, subfamily 2, member A2
C11ORF16 chromosome 11 open reading frame 16
C16ORF58 chromosome 16 open reading frame 58
C5ORF45 chromosome 5 open reading frame 45
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CCL20 chemokine (C-C motif) ligand 20
CD248 CD248 molecule, endosialin
CD59 CD59 molecule, complement regulatory protein
CDCP1 CUB domain containing protein 1
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
CECR1 cat eye syndrome chromosome region, candidate 1
CEP41 centrosomal protein 41kDa
CHPF2 chondroitin polymerizing factor 2
CLCN4 chloride channel, voltage-sensitive 4
CLDN7 claudin 7
CLGN calmegin
CNTN1 contactin 1
COL7A1 collagen, type VII, alpha 1
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34
DMC1 DNA meiotic recombinase 1
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1
DTNA dystrobrevin, alpha
EFR3B EFR3 homolog B (S. cerevisiae)
F11R F11 receptor
FAAH fatty acid amide hydrolase
FAM13A family with sequence similarity 13, member A
FAM49A family with sequence similarity 49, member A
GLRX glutaredoxin (thioltransferase)
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GSDMB gasdermin B
IFI30 interferon, gamma-inducible protein 30
IQSEC1 IQ motif and Sec7 domain 1
KEL Kell blood group, metallo-endopeptidase
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
KLHL36 kelch-like family member 36
LAIR2 leukocyte-associated immunoglobulin-like receptor 2
LHFP lipoma HMGIC fusion partner
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1
LRP2 low density lipoprotein receptor-related protein 2
LRRC6 leucine rich repeat containing 6
LY6G5C lymphocyte antigen 6 complex, locus G5C
MAGIX MAGI family member, X-linked
MAOA monoamine oxidase A
MAP4 microtubule-associated protein 4
MR1 major histocompatibility complex, class I-related
MST1 macrophage stimulating 1
MTFR1 mitochondrial fission regulator 1
MUC1 mucin 1, cell surface associated
MUL1 mitochondrial E3 ubiquitin protein ligase 1
NANOG Nanog homeobox
OGFR opioid growth factor receptor
OSBPL10 oxysterol binding protein-like 10
PIP prolactin-induced protein
PLD3 phospholipase D family, member 3
PML promyelocytic leukemia
PRDM10 PR domain containing 10
PRSS53 protease, serine, 53
PTGDS prostaglandin D2 synthase 21kDa (brain)
RGS10 regulator of G-protein signaling 10
RPS2 ribosomal protein S2
RUNX1 runt-related transcription factor 1
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SGPP1 sphingosine-1-phosphate phosphatase 1
SH3BP2 SH3-domain binding protein 2
SIRPA signal-regulatory protein alpha
SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5
SLC26A4 solute carrier family 26 (anion exchanger), member 4
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SP140 SP140 nuclear body protein
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SPTBN1 spectrin, beta, non-erythrocytic 1
STAT5A signal transducer and activator of transcription 5A
STK25 serine/threonine kinase 25
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TAS2R1 taste receptor, type 2, member 1
TCP11L1 t-complex 11, testis-specific-like 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THAP3 THAP domain containing, apoptosis associated protein 3
TSPAN4 tetraspanin 4
TUBA4B tubulin, alpha 4b
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae)
ZNF177 zinc finger protein 177
ZNF202 zinc finger protein 202
ZNF609 zinc finger protein 609

decreased expression

Symbol Name
ALG12 ALG12, alpha-1,6-mannosyltransferase
AMDHD2 amidohydrolase domain containing 2
ATAD3A ATPase family, AAA domain containing 3A
BAAT bile acid CoA:amino acid N-acyltransferase
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BEND5 BEN domain containing 5
BNC2 basonuclin 2
C1ORF159 chromosome 1 open reading frame 159
C3ORF18 chromosome 3 open reading frame 18
CCDC186 coiled-coil domain containing 186
CD37 CD37 molecule
CGREF1 cell growth regulator with EF-hand domain 1
CISH cytokine inducible SH2-containing protein
CPTP ceramide-1-phosphate transfer protein
DEFB1 defensin, beta 1
DHRS11 dehydrogenase/reductase (SDR family) member 11
DOK3 docking protein 3
DSE dermatan sulfate epimerase
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EFNA3 ephrin-A3
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
ERN2 endoplasmic reticulum to nucleus signaling 2
EXD3 exonuclease 3'-5' domain containing 3
FAM46C family with sequence similarity 46, member C
FBXL7 F-box and leucine-rich repeat protein 7
FMOD fibromodulin
FRS3 fibroblast growth factor receptor substrate 3
GAMT guanidinoacetate N-methyltransferase
GJA9 gap junction protein, alpha 9, 59kDa
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HAMP hepcidin antimicrobial peptide
HIST1H1T histone cluster 1, H1t
HIST1H3G histone cluster 1, H3g
HOXA4 homeobox A4
HOXC8 homeobox C8
IFI6 interferon, alpha-inducible protein 6
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
INF2 inverted formin, FH2 and WH2 domain containing
JMJD4 jumonji domain containing 4
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIAA0556 KIAA0556
KIF3A kinesin family member 3A
LHFPL2 lipoma HMGIC fusion partner-like 2
LOC729164 hCG1732469
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MATK megakaryocyte-associated tyrosine kinase
MKRN3 makorin ring finger protein 3
MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
MRPS18C mitochondrial ribosomal protein S18C
NDE1 nudE neurodevelopment protein 1
NKX3-2 NK3 homeobox 2
NOL10 nucleolar protein 10
PADI1 peptidyl arginine deiminase, type I
PADI2 peptidyl arginine deiminase, type II
PCDHGA8 protocadherin gamma subfamily A, 8
PDGFD platelet derived growth factor D
PDGFRL platelet-derived growth factor receptor-like
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PLCL1 phospholipase C-like 1
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PMFBP1 polyamine modulated factor 1 binding protein 1
PODNL1 podocan-like 1
POLH polymerase (DNA directed), eta
POLL polymerase (DNA directed), lambda
PROCR protein C receptor, endothelial
PRR4 proline rich 4 (lacrimal)
PTTG3P pituitary tumor-transforming 3, pseudogene
QSER1 glutamine and serine rich 1
RANBP17 RAN binding protein 17
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
SCUBE3 signal peptide, CUB domain, EGF-like 3
SHPK sedoheptulokinase
SNAI1 snail family zinc finger 1
SP1 Sp1 transcription factor
SSBP3 single stranded DNA binding protein 3
SYNDIG1 synapse differentiation inducing 1
SYNJ2BP synaptojanin 2 binding protein
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TCTN2 tectonic family member 2
TGFB3 transforming growth factor, beta 3
THAP10 THAP domain containing 10
TMEM206 transmembrane protein 206
TMEM246 transmembrane protein 246
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1
TSC22D4 TSC22 domain family, member 4
TSPAN13 tetraspanin 13
USP27X ubiquitin specific peptidase 27, X-linked
XYLT2 xylosyltransferase II
YPEL1 yippee-like 1 (Drosophila)
ZBTB22 zinc finger and BTB domain containing 22
ZC4H2 zinc finger, C4H2 domain containing
ZFHX2 zinc finger homeobox 2
ZNF219 zinc finger protein 219
ZNF549 zinc finger protein 549
ZNF667 zinc finger protein 667
ZNF747 zinc finger protein 747