cyclopenthiazide-4229 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the cyclopenthiazide-4229 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAK1 AP2 associated kinase 1
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
ADAM11 ADAM metallopeptidase domain 11
ADGRL3 adhesion G protein-coupled receptor L3
AGFG2 ArfGAP with FG repeats 2
ALOXE3 arachidonate lipoxygenase 3
ARHGAP4 Rho GTPase activating protein 4
ARR3 arrestin 3, retinal (X-arrestin)
ASCL1 achaete-scute family bHLH transcription factor 1
BEST1 bestrophin 1
C11ORF16 chromosome 11 open reading frame 16
CA1 carbonic anhydrase I
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CAMK1G calcium/calmodulin-dependent protein kinase IG
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CCR7 chemokine (C-C motif) receptor 7
CD244 CD244 molecule, natural killer cell receptor 2B4
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP2U1 cytochrome P450, family 2, subfamily U, polypeptide 1
DCHS1 dachsous cadherin-related 1
DCHS2 dachsous cadherin-related 2
DIO3 deiodinase, iodothyronine, type III
DLGAP1 discs, large (Drosophila) homolog-associated protein 1
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5
DOPEY1 dopey family member 1
DUSP7 dual specificity phosphatase 7
EDNRA endothelin receptor type A
EFCAB6 EF-hand calcium binding domain 6
EPHA3 EPH receptor A3
EPHB1 EPH receptor B1
FLJ11292
FOXP3 forkhead box P3
HIST1H3I histone cluster 1, H3i
HOXB3 homeobox B3
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic
IDS iduronate 2-sulfatase
IFNA6 interferon, alpha 6
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4
KIF25-AS1 KIF25 antisense RNA 1
LARGE like-glycosyltransferase
LECT2 leukocyte cell-derived chemotaxin 2
LOC145678 uncharacterized LOC145678
LY9 lymphocyte antigen 9
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAN2A2 mannosidase, alpha, class 2A, member 2
MAPRE3 microtubule-associated protein, RP/EB family, member 3
MFAP3L microfibrillar-associated protein 3-like
MON2 MON2 homolog (S. cerevisiae)
MYCNOS MYCN opposite strand
N4BP2L1 NEDD4 binding protein 2-like 1
NEFM neurofilament, medium polypeptide
NEUROD1 neuronal differentiation 1
NPAS1 neuronal PAS domain protein 1
NPPB natriuretic peptide B
NPR1 natriuretic peptide receptor 1
NRXN2 neurexin 2
ORM1 orosomucoid 1
OTOF otoferlin
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PIPOX pipecolic acid oxidase
POU1F1 POU class 1 homeobox 1
PRB1 proline-rich protein BstNI subfamily 1
PRDM12 PR domain containing 12
PRDM14 PR domain containing 14
PRDM2 PR domain containing 2, with ZNF domain
RAG2 recombination activating gene 2
RASAL2 RAS protein activator like 2
RDH8 retinol dehydrogenase 8 (all-trans)
RGS14 regulator of G-protein signaling 14
RGS5 regulator of G-protein signaling 5
SERHL2 serine hydrolase-like 2
SHANK2 SH3 and multiple ankyrin repeat domains 2
SLC18A1 solute carrier family 18 (vesicular monoamine transporter), member 1
SNCG synuclein, gamma (breast cancer-specific protein 1)
SNED1 sushi, nidogen and EGF-like domains 1
SPO11 SPO11 meiotic protein covalently bound to DSB
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3
ST14 suppression of tumorigenicity 14 (colon carcinoma)
SUSD5 sushi domain containing 5
SYT5 synaptotagmin V
TEX13A testis expressed 13A
TJP3 tight junction protein 3
TLX2 T-cell leukemia homeobox 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIM31 tripartite motif containing 31
TRPM6 transient receptor potential cation channel, subfamily M, member 6
TTC38 tetratricopeptide repeat domain 38
TTYH1 tweety family member 1
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VCX2 variable charge, X-linked 2
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae)
ZBTB33 zinc finger and BTB domain containing 33
ZCCHC14 zinc finger, CCHC domain containing 14
ZNF674 zinc finger protein 674
ZNF814 zinc finger protein 814

decreased expression

Symbol Name
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
ANKFY1 ankyrin repeat and FYVE domain containing 1
ARHGAP10 Rho GTPase activating protein 10
ARHGAP24 Rho GTPase activating protein 24
ATAD5 ATPase family, AAA domain containing 5
BATF3 basic leucine zipper transcription factor, ATF-like 3
BCAS3 breast carcinoma amplified sequence 3
BGLAP bone gamma-carboxyglutamate (gla) protein
C4ORF29 chromosome 4 open reading frame 29
CFAP45 cilia and flagella associated protein 45
CISH cytokine inducible SH2-containing protein
CLDN11 claudin 11
CNIH3 cornichon family AMPA receptor auxiliary protein 3
CNTLN centlein, centrosomal protein
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CRYBB2P1 crystallin, beta B2 pseudogene 1
CSRNP3 cysteine-serine-rich nuclear protein 3
CTC1 CTS telomere maintenance complex component 1
CUZD1 CUB and zona pellucida-like domains 1
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae)
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DENND4A DENN/MADD domain containing 4A
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1
EFNA3 ephrin-A3
EGF epidermal growth factor
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
ERF Ets2 repressor factor
FAM69A family with sequence similarity 69, member A
GID4 GID complex subunit 4
GJC1 gap junction protein, gamma 1, 45kDa
GLDC glycine dehydrogenase (decarboxylating)
GLTSCR1 glioma tumor suppressor candidate region gene 1
GMEB1 glucocorticoid modulatory element binding protein 1
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GSTCD glutathione S-transferase, C-terminal domain containing
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIST1H2AJ histone cluster 1, H2aj
IL11RA interleukin 11 receptor, alpha
KIAA1456 KIAA1456
KIF13B kinesin family member 13B
KLF2 Kruppel-like factor 2
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LIG4 ligase IV, DNA, ATP-dependent
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LOC100286895 cell division cycle 27 homolog pseudogene
LPPR4 lipid phosphate phosphatase-related protein type 4
LRRC37A4P leucine rich repeat containing 37, member A4, pseudogene
MAST3 microtubule associated serine/threonine kinase 3
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MYO1E myosin IE
NMB neuromedin B
NOD1 nucleotide-binding oligomerization domain containing 1
NR1H3 nuclear receptor subfamily 1, group H, member 3
OSR2 odd-skipped related transciption factor 2
PALMD palmdelphin
PDE8B phosphodiesterase 8B
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLA2G15 phospholipase A2, group XV
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLAC8 placenta-specific 8
PLCD1 phospholipase C, delta 1
PLEKHO1 pleckstrin homology domain containing, family O member 1
PLEKHO2 pleckstrin homology domain containing, family O member 2
PLXNA3 plexin A3
POM121 POM121 transmembrane nucleoporin
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PRSS8 protease, serine, 8
QTRT1 queuine tRNA-ribosyltransferase 1
RBL1 retinoblastoma-like 1
REPS2 RALBP1 associated Eps domain containing 2
S100A3 S100 calcium binding protein A3
SHROOM2 shroom family member 2
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SNX10 sorting nexin 10
SOD3 superoxide dismutase 3, extracellular
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TAGLN3 transgelin 3
TBC1D22B TBC1 domain family, member 22B
TEX40 testis expressed 40
THBS3 thrombospondin 3
TMEM183A transmembrane protein 183A
TMEM242 transmembrane protein 242
TRAPPC13 trafficking protein particle complex 13
TRIM25 tripartite motif containing 25
TWISTNB TWIST neighbor
TXLNG taxilin gamma
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
ZNF33B zinc finger protein 33B
ZNF34 zinc finger protein 34
ZNF529 zinc finger protein 529
ZNF606 zinc finger protein 606
ZNF767P zinc finger family member 767, pseudogene