cyclopentolate-5734 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the cyclopentolate-5734 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSL5 acyl-CoA synthetase long-chain family member 5
ADGRB2 adhesion G protein-coupled receptor B2
AJAP1 adherens junctions associated protein 1
AKAP8L A kinase (PRKA) anchor protein 8-like
AKT3 v-akt murine thymoma viral oncogene homolog 3
APOF apolipoprotein F
APP amyloid beta (A4) precursor protein
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15
ARNT aryl hydrocarbon receptor nuclear translocator
ARTN artemin
ATAD5 ATPase family, AAA domain containing 5
ATXN2L ataxin 2-like
BMP2 bone morphogenetic protein 2
BRS3 bombesin-like receptor 3
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C17ORF80 chromosome 17 open reading frame 80
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
CBS cystathionine-beta-synthase
CDHR2 cadherin-related family member 2
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3
CECR1 cat eye syndrome chromosome region, candidate 1
CLPS colipase, pancreatic
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
CSE1L CSE1 chromosome segregation 1-like (yeast)
DMP1 dentin matrix acidic phosphoprotein 1
DPY19L1P1 DPY19L1 pseudogene 1
DUSP7 dual specificity phosphatase 7
FAM65B family with sequence similarity 65, member B
FCMR Fc fragment of IgM receptor
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
GBP1 guanylate binding protein 1, interferon-inducible
GPR15 G protein-coupled receptor 15
GRTP1 growth hormone regulated TBC protein 1
HBS1L HBS1-like translational GTPase
HLA-DMA major histocompatibility complex, class II, DM alpha
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
IGSF6 immunoglobulin superfamily, member 6
ING4 inhibitor of growth family, member 4
IQCK IQ motif containing K
ITGA7 integrin, alpha 7
JPH3 junctophilin 3
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1
KCTD14 potassium channel tetramerization domain containing 14
KIAA0319L KIAA0319-like
L3MBTL1 l(3)mbt-like 1 (Drosophila)
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
LY6G6C lymphocyte antigen 6 complex, locus G6C
MAGED2 melanoma antigen family D2
MCOLN3 mucolipin 3
MFAP3L microfibrillar-associated protein 3-like
MPPE1 metallophosphoesterase 1
MST1L macrophage stimulating 1-like
MTSS1L metastasis suppressor 1-like
NCLN nicalin
NCR2 natural cytotoxicity triggering receptor 2
NEK11 NIMA-related kinase 11
NUP214 nucleoporin 214kDa
OTOR otoraplin
PAX7 paired box 7
PDE4D phosphodiesterase 4D, cAMP-specific
PGLYRP1 peptidoglycan recognition protein 1
PIP prolactin-induced protein
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
POM121L2 POM121 transmembrane nucleoporin-like 2
PPP5C protein phosphatase 5, catalytic subunit
PTGIS prostaglandin I2 (prostacyclin) synthase
RAB6A RAB6A, member RAS oncogene family
RABEP1 rabaptin, RAB GTPase binding effector protein 1
RABGAP1L RAB GTPase activating protein 1-like
RAD51B RAD51 paralog B
RAMP2 receptor (G protein-coupled) activity modifying protein 2
REM1 RAS (RAD and GEM)-like GTP-binding 1
RNF39 ring finger protein 39
RPLP2 ribosomal protein, large, P2
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
RUNX2 runt-related transcription factor 2
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC25A30 solute carrier family 25, member 30
SLC38A7 solute carrier family 38, member 7
SMEK1 SMEK homolog 1, suppressor of mek1 (Dictyostelium)
SMO smoothened, frizzled class receptor
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SPPL2B signal peptide peptidase like 2B
SRPK2 SRSF protein kinase 2
STAB1 stabilin 1
STARD5 StAR-related lipid transfer (START) domain containing 5
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
TAS2R10 taste receptor, type 2, member 10
UBE2I ubiquitin-conjugating enzyme E2I
USP22 ubiquitin specific peptidase 22
VGLL3 vestigial-like family member 3
WDR55 WD repeat domain 55
WDR59 WD repeat domain 59
ZER1 zyg-11 related, cell cycle regulator
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF76 zinc finger protein 76

decreased expression

Symbol Name
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ADAP2 ArfGAP with dual PH domains 2
ANKRD36 ankyrin repeat domain 36
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BAHCC1 BAH domain and coiled-coil containing 1
BAX BCL2-associated X protein
C1ORF105 chromosome 1 open reading frame 105
CCP110 centriolar coiled coil protein 110kDa
CLDN15 claudin 15
CLDN8 claudin 8
CNGB3 cyclic nucleotide gated channel beta 3
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
COG4 component of oligomeric golgi complex 4
CREB5 cAMP responsive element binding protein 5
CRYBA2 crystallin, beta A2
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DHDDS dehydrodolichyl diphosphate synthase
DTX2 deltex 2, E3 ubiquitin ligase
EYA4 EYA transcriptional coactivator and phosphatase 4
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FBXO2 F-box protein 2
FGL1 fibrinogen-like 1
FRS3 fibroblast growth factor receptor substrate 3
FSD1 fibronectin type III and SPRY domain containing 1
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GAL3ST4 galactose-3-O-sulfotransferase 4
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GRWD1 glutamate-rich WD repeat containing 1
HIRA histone cell cycle regulator
HIST1H2AJ histone cluster 1, H2aj
HIST1H2BM histone cluster 1, H2bm
HMOX1 heme oxygenase 1
HOXC10 homeobox C10
IFNA14 interferon, alpha 14
IGSF3 immunoglobulin superfamily, member 3
IL12A interleukin 12A
IPO8 importin 8
ITK IL2-inducible T-cell kinase
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
KDM5C lysine (K)-specific demethylase 5C
KIFC1 kinesin family member C1
KLC2 kinesin light chain 2
KRT31 keratin 31, type I
LIPG lipase, endothelial
LOC257152 uncharacterized LOC257152
LRP2 low density lipoprotein receptor-related protein 2
MAGEB2 melanoma antigen family B2
MFGE8 milk fat globule-EGF factor 8 protein
MNS1 meiosis-specific nuclear structural 1
MYL5 myosin, light chain 5, regulatory
MYLK myosin light chain kinase
NME5 NME/NM23 family member 5
NPM3 nucleophosmin/nucleoplasmin 3
NTSR1 neurotensin receptor 1 (high affinity)
NUBP1 nucleotide binding protein 1
ODF2 outer dense fiber of sperm tails 2
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
ORAI3 ORAI calcium release-activated calcium modulator 3
OTUD3 OTU deubiquitinase 3
OVGP1 oviductal glycoprotein 1, 120kDa
PAQR6 progestin and adipoQ receptor family member VI
PCDHGB5 protocadherin gamma subfamily B, 5
PDGFRL platelet-derived growth factor receptor-like
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PRR3 proline rich 3
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RNF122 ring finger protein 122
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SCAMP5 secretory carrier membrane protein 5
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1
SLC46A3 solute carrier family 46, member 3
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
SSBP3 single stranded DNA binding protein 3
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
SULT4A1 sulfotransferase family 4A, member 1
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box)
THBS3 thrombospondin 3
TM6SF1 transmembrane 6 superfamily member 1
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TSKU tsukushi, small leucine rich proteoglycan
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
UBTD1 ubiquitin domain containing 1
VGF VGF nerve growth factor inducible
ZFHX2 zinc finger homeobox 2
ZNF226 zinc finger protein 226
ZNF276 zinc finger protein 276
ZNF41 zinc finger protein 41
ZNF623 zinc finger protein 623
ZNF84 zinc finger protein 84
ZNHIT2 zinc finger, HIT-type containing 2