cycloserine-3562 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

193 genes differentially expressed following the cycloserine-3562 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACSL5 acyl-CoA synthetase long-chain family member 5
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
B9D2 B9 protein domain 2
BDKRB2 bradykinin receptor B2
BGN biglycan
C1QB complement component 1, q subcomponent, B chain
CA5B carbonic anhydrase VB, mitochondrial
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CACTIN cactin, spliceosome C complex subunit
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CDA cytidine deaminase
CDK19 cyclin-dependent kinase 19
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CLEC3B C-type lectin domain family 3, member B
COL1A2 collagen, type I, alpha 2
COL8A1 collagen, type VIII, alpha 1
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CTSF cathepsin F
DAPK2 death-associated protein kinase 2
DFNB31 deafness, autosomal recessive 31
DOCK4 dedicator of cytokinesis 4
EFNB3 ephrin-B3
EN2 engrailed homeobox 2
FER1L4 fer-1-like family member 4, pseudogene (functional)
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
GPR153 G protein-coupled receptor 153
GRIP2 glutamate receptor interacting protein 2
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HMG20B high mobility group 20B
HOMER3 homer scaffolding protein 3
HPX hemopexin
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
ICAM5 intercellular adhesion molecule 5, telencephalin
IGFBP7 insulin-like growth factor binding protein 7
INHBA inhibin, beta A
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
JMJD4 jumonji domain containing 4
KHSRP KH-type splicing regulatory protein
KIAA0195 KIAA0195
KIAA1462 KIAA1462
KLF12 Kruppel-like factor 12
KRT6B keratin 6B, type II
LAMC3 laminin, gamma 3
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LOC100131532 uncharacterized LOC100131532
MCF2 MCF.2 cell line derived transforming sequence
MED9 mediator complex subunit 9
MFAP3L microfibrillar-associated protein 3-like
MUC6 mucin 6, oligomeric mucus/gel-forming
MYL2 myosin, light chain 2, regulatory, cardiac, slow
NGFR nerve growth factor receptor
NME5 NME/NM23 family member 5
NOX1 NADPH oxidase 1
NT5M 5',3'-nucleotidase, mitochondrial
PAOX polyamine oxidase (exo-N4-amino)
PBX2 pre-B-cell leukemia homeobox 2
PDE4DIP phosphodiesterase 4D interacting protein
PDLIM7 PDZ and LIM domain 7 (enigma)
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLCG1 phospholipase C, gamma 1
PLEKHS1 pleckstrin homology domain containing, family S member 1
POMT2 protein-O-mannosyltransferase 2
PRODH proline dehydrogenase (oxidase) 1
PSAT1 phosphoserine aminotransferase 1
PTPRB protein tyrosine phosphatase, receptor type, B
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RGS1 regulator of G-protein signaling 1
RND1 Rho family GTPase 1
SAYSD1 SAYSVFN motif domain containing 1
SEC14L2 SEC14-like 2 (S. cerevisiae)
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5
SLC35E2 solute carrier family 35, member E2
SLIT2 slit homolog 2 (Drosophila)
SORCS3 sortilin-related VPS10 domain containing receptor 3
STRA6 stimulated by retinoic acid 6
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
SYK spleen tyrosine kinase
SZT2 seizure threshold 2 homolog (mouse)
TH tyrosine hydroxylase
TNC tenascin C
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TPP1 tripeptidyl peptidase I
TRIM38 tripartite motif containing 38
TRIM49 tripartite motif containing 49
TUBBP5 tubulin, beta pseudogene 5
UBXN1 UBX domain protein 1
WIZ widely interspaced zinc finger motifs
WNT16 wingless-type MMTV integration site family, member 16
XIST X inactive specific transcript (non-protein coding)
YIPF2 Yip1 domain family, member 2
ZBTB18 zinc finger and BTB domain containing 18
ZC3H11A zinc finger CCCH-type containing 11A
ZC3H7B zinc finger CCCH-type containing 7B
ZNF154 zinc finger protein 154
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ACTL8 actin-like 8
ADAP2 ArfGAP with dual PH domains 2
ADAT1 adenosine deaminase, tRNA-specific 1
ALPK1 alpha-kinase 1
AR androgen receptor
ARID4A AT rich interactive domain 4A (RBP1-like)
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BAG4 BCL2-associated athanogene 4
C11ORF63 chromosome 11 open reading frame 63
C19ORF40 chromosome 19 open reading frame 40
C21ORF91 chromosome 21 open reading frame 91
CCDC186 coiled-coil domain containing 186
CCNT1 cyclin T1
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CENPC centromere protein C
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DCAF16 DDB1 and CUL4 associated factor 16
DENND4C DENN/MADD domain containing 4C
DEPDC1 DEP domain containing 1
DMC1 DNA meiotic recombinase 1
DSCAM Down syndrome cell adhesion molecule
EDEM3 ER degradation enhancer, mannosidase alpha-like 3
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ERN2 endoplasmic reticulum to nucleus signaling 2
F3 coagulation factor III (thromboplastin, tissue factor)
FBXW12 F-box and WD repeat domain containing 12
FGGY FGGY carbohydrate kinase domain containing
FIP1L1 factor interacting with PAPOLA and CPSF1
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GINS4 GINS complex subunit 4 (Sld5 homolog)
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GSTCD glutathione S-transferase, C-terminal domain containing
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
GUSBP3 glucuronidase, beta pseudogene 3
HELLS helicase, lymphoid-specific
HIST1H1E histone cluster 1, H1e
IFT140 intraflagellar transport 140
IGSF1 immunoglobulin superfamily, member 1
INCENP inner centromere protein antigens 135/155kDa
IPP intracisternal A particle-promoted polypeptide
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KIAA0556 KIAA0556
KIAA0894 KIAA0894 protein
LIG4 ligase IV, DNA, ATP-dependent
LIN7A lin-7 homolog A (C. elegans)
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LYPD1 LY6/PLAUR domain containing 1
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MBNL3 muscleblind-like splicing regulator 3
METTL16 methyltransferase like 16
MGC12488
MPHOSPH8 M-phase phosphoprotein 8
N4BP3 NEDD4 binding protein 3
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NR1D2 nuclear receptor subfamily 1, group D, member 2
PARPBP PARP1 binding protein
PCYOX1 prenylcysteine oxidase 1
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PRR14L proline rich 14-like
PTDSS2 phosphatidylserine synthase 2
PTK6 protein tyrosine kinase 6
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6
RBBP5 retinoblastoma binding protein 5
RFWD3 ring finger and WD repeat domain 3
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
SCD5 stearoyl-CoA desaturase 5
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SPATS2 spermatogenesis associated, serine-rich 2
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
TBC1D19 TBC1 domain family, member 19
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor)
TM6SF1 transmembrane 6 superfamily member 1
TMEM104 transmembrane protein 104
TRIM16 tripartite motif containing 16
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae)
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
UBE2W ubiquitin-conjugating enzyme E2W (putative)
UBQLN4 ubiquilin 4
UNC119 unc-119 homolog (C. elegans)
USP27X ubiquitin specific peptidase 27, X-linked
USP36 ubiquitin specific peptidase 36
VASH2 vasohibin 2
VGF VGF nerve growth factor inducible
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZNF254 zinc finger protein 254
ZNF324 zinc finger protein 324
ZNF430 zinc finger protein 430
ZNF611 zinc finger protein 611
ZNF652 zinc finger protein 652
ZNF721 zinc finger protein 721
ZNF91 zinc finger protein 91