cyp1a1 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description cytochrome P450, family 1, subfamily A, polypeptide 1|This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1543)
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Genes

59 genes co-occuring with the biological term cyp1a1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACE angiotensin I converting enzyme
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AHR aryl hydrocarbon receptor
AHRR aryl-hydrocarbon receptor repressor
BRCA1 breast cancer 1, early onset
CASP9 caspase 9, apoptosis-related cysteine peptidase
CDKN2A cyclin-dependent kinase inhibitor 2A
COMT catechol-O-methyltransferase
CREM cAMP responsive element modulator
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
CYP3A7 cytochrome P450, family 3, subfamily A, polypeptide 7
DIO2 deiodinase, iodothyronine, type II
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERCC5 excision repair cross-complementation group 5
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
GCLC glutamate-cysteine ligase, catalytic subunit
GSTM1 glutathione S-transferase mu 1
GSTM3 glutathione S-transferase mu 3 (brain)
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HMOX1 heme oxygenase 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
IL4 interleukin 4
IL6 interleukin 6
KLF13 Kruppel-like factor 13
KLF16 Kruppel-like factor 16
KLF4 Kruppel-like factor 4 (gut)
MIR892A microRNA 892a
MPO myeloperoxidase
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NR1H3 nuclear receptor subfamily 1, group H, member 3
NR1I3 nuclear receptor subfamily 1, group I, member 3
PPARA peroxisome proliferator-activated receptor alpha
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
SNCG synuclein, gamma (breast cancer-specific protein 1)
SOD2 superoxide dismutase 2, mitochondrial
SP1 Sp1 transcription factor
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLR2 toll-like receptor 2
TNF tumor necrosis factor
TP53 tumor protein p53