cyp1a2 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description cytochrome P450, family 1, subfamily A, polypeptide 2|This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1544)
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Genes

23 genes co-occuring with the biological term cyp1a2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ADORA2A adenosine A2a receptor
AHR aryl hydrocarbon receptor
AHRR aryl-hydrocarbon receptor repressor
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
GSTM1 glutathione S-transferase mu 1
GSTT1 glutathione S-transferase theta 1
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NQO1 NAD(P)H dehydrogenase, quinone 1
NR1H3 nuclear receptor subfamily 1, group H, member 3
NR1I3 nuclear receptor subfamily 1, group I, member 3
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
USF1 upstream transcription factor 1
USF2 upstream transcription factor 2, c-fos interacting