cyp2a6 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description cytochrome P450, family 2, subfamily A, polypeptide 6|This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1548)
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Genes

26 genes co-occuring with the biological term cyp2a6 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal)
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP2A cytochrome P450, family 2, subfamily A
CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase)
EGLN2 egl-9 family hypoxia-inducible factor 2
ESR1 estrogen receptor 1
GSTM1 glutathione S-transferase mu 1
GSTT1 glutathione S-transferase theta 1
MAOA monoamine oxidase A
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NFE2L2 nuclear factor, erythroid 2-like 2
NR1I2 nuclear receptor subfamily 1, group I, member 2
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
UGT2B10 UDP glucuronosyltransferase 2 family, polypeptide B10
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7