cyp2b6 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description cytochrome P450, family 2, subfamily B, polypeptide 6|This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1555)
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Genes

31 genes co-occuring with the biological term cyp2b6 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ATF5 activating transcription factor 5
CDK2 cyclin-dependent kinase 2
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CXADR coxsackie virus and adenovirus receptor
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP2F1 cytochrome P450, family 2, subfamily F, polypeptide 1
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
EGR1 early growth response 1
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
GSTP1 glutathione S-transferase pi 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HNF4A hepatocyte nuclear factor 4, alpha
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NR1I2 nuclear receptor subfamily 1, group I, member 2
NR1I3 nuclear receptor subfamily 1, group I, member 3
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16
SMC1A structural maintenance of chromosomes 1A
SOD2 superoxide dismutase 2, mitochondrial
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor