cyp2c19 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description cytochrome P450, family 2, subfamily C, polypeptide 19|This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1557)
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Genes

26 genes co-occuring with the biological term cyp2c19 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
APOE apolipoprotein E
CES1P1 carboxylesterase 1 pseudogene 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
CYP3A cytochrome P450, family 3, subfamily A
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
GATA4 GATA binding protein 4
GGCX gamma-glutamyl carboxylase
IL1B interleukin 1, beta
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
MIR34A microRNA 34a
P2RY12 purinergic receptor P2Y, G-protein coupled, 12
PON1 paraoxonase 1
POR P450 (cytochrome) oxidoreductase
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLCO1B1 solute carrier organic anion transporter family, member 1B1
SOD2 superoxide dismutase 2, mitochondrial
VKORC1 vitamin K epoxide reductase complex, subunit 1