| Dataset | GeneRIF Biological Term Annotations |
| Category | structural or functional annotations |
| Type | biological term |
| Description | cytochrome P450, family 2, subfamily C, polypeptide 8|This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010] (NCBI Entrez Gene Database, 1558) |
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17 genes co-occuring with the biological term cyp2c8 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
| Symbol | Name |
|---|---|
| ABCB1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 |
| ABCC2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 |
| CYP2C19 | cytochrome P450, family 2, subfamily C, polypeptide 19 |
| CYP2C8 | cytochrome P450, family 2, subfamily C, polypeptide 8 |
| CYP2C9 | cytochrome P450, family 2, subfamily C, polypeptide 9 |
| CYP2E1 | cytochrome P450, family 2, subfamily E, polypeptide 1 |
| CYP2J2 | cytochrome P450, family 2, subfamily J, polypeptide 2 |
| CYP3A4 | cytochrome P450, family 3, subfamily A, polypeptide 4 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 |
| EPHX2 | epoxide hydrolase 2, cytoplasmic |
| HNF4A | hepatocyte nuclear factor 4, alpha |
| MIR107 | microRNA 107 |
| NR1I2 | nuclear receptor subfamily 1, group I, member 2 |
| NR1I3 | nuclear receptor subfamily 1, group I, member 3 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) |
| SLCO1B1 | solute carrier organic anion transporter family, member 1B1 |
| UGT2B7 | UDP glucuronosyltransferase 2 family, polypeptide B7 |
