cyp2c9 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description cytochrome P450, family 2, subfamily C, polypeptide 9|This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1559)
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Genes

40 genes co-occuring with the biological term cyp2c9 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
APOE apolipoprotein E
CRP C-reactive protein, pentraxin-related
CXADR coxsackie virus and adenovirus receptor
CYB5A cytochrome b5 type A (microsomal)
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2
EPHB4 EPH receptor B4
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EPHX2 epoxide hydrolase 2, cytoplasmic
ESR1 estrogen receptor 1
GATA4 GATA binding protein 4
GGCX gamma-glutamyl carboxylase
HLA-B major histocompatibility complex, class I, B
HNF4A hepatocyte nuclear factor 4, alpha
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
MED25 mediator complex subunit 25
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NCOA6 nuclear receptor coactivator 6
NR1I2 nuclear receptor subfamily 1, group I, member 2
NR1I3 nuclear receptor subfamily 1, group I, member 3
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
POR P450 (cytochrome) oxidoreductase
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SLCO1B1 solute carrier organic anion transporter family, member 1B1
THBD thrombomodulin
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VKORC1 vitamin K epoxide reductase complex, subunit 1