cyproheptadine-1521 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the cyproheptadine-1521 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADCK4 aarF domain containing kinase 4
ADCY7 adenylate cyclase 7
AHNAK2 AHNAK nucleoprotein 2
AMELX amelogenin, X-linked
APOC1 apolipoprotein C-I
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARTN artemin
ASAP1-IT1 ASAP1 intronic transcript 1
ATF3 activating transcription factor 3
ATP10B ATPase, class V, type 10B
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAHCC1 BAH domain and coiled-coil containing 1
BAIAP2 BAI1-associated protein 2
BHLHE40 basic helix-loop-helix family, member e40
BMP1 bone morphogenetic protein 1
CDK18 cyclin-dependent kinase 18
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
CPA4 carboxypeptidase A4
CPNE7 copine VII
DCAKD dephospho-CoA kinase domain containing
DDIT3 DNA-damage-inducible transcript 3
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5
DOCK5 dedicator of cytokinesis 5
DUSP2 dual specificity phosphatase 2
EGR1 early growth response 1
EPHB2 EPH receptor B2
ERC1 ELKS/RAB6-interacting/CAST family member 1
ETV5 ets variant 5
EVA1B eva-1 homolog B (C. elegans)
FAM114A1 family with sequence similarity 114, member A1
FAM212B family with sequence similarity 212, member B
FAM46C family with sequence similarity 46, member C
FBXO21 F-box protein 21
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
GTDC1 glycosyltransferase-like domain containing 1
HCFC1 host cell factor C1
HEG1 heart development protein with EGF-like domains 1
HOPX HOP homeobox
HRK harakiri, BCL2 interacting protein
IFIT5 interferon-induced protein with tetratricopeptide repeats 5
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIF13B kinesin family member 13B
LHX6 LIM homeobox 6
LINC00341 long intergenic non-protein coding RNA 341
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK7 mitogen-activated protein kinase 7
MARK4 MAP/microtubule affinity-regulating kinase 4
MARS methionyl-tRNA synthetase
MCFD2 multiple coagulation factor deficiency 2
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MSL3 male-specific lethal 3 homolog (Drosophila)
MTA1 metastasis associated 1
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
OGFR opioid growth factor receptor
OLFML2A olfactomedin-like 2A
ORAI2 ORAI calcium release-activated calcium modulator 2
PBX2 pre-B-cell leukemia homeobox 2
PCDH9 protocadherin 9
PCDHGA3 protocadherin gamma subfamily A, 3
PEX26 peroxisomal biogenesis factor 26
PLAC4 placenta-specific 4
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PTGIS prostaglandin I2 (prostacyclin) synthase
PTN pleiotrophin
PVR poliovirus receptor
RBM5 RNA binding motif protein 5
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHOBTB2 Rho-related BTB domain containing 2
RNF126P1 ring finger protein 126 pseudogene 1
SAP30 Sin3A-associated protein, 30kDa
SCHIP1 schwannomin interacting protein 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SIX2 SIX homeobox 2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SMAD1 SMAD family member 1
SMIM14 small integral membrane protein 14
SNAI2 snail family zinc finger 2
SWAP70 SWAP switching B-cell complex 70kDa subunit
SYNJ2 synaptojanin 2
TBC1D2 TBC1 domain family, member 2
TMEM176A transmembrane protein 176A
TMEM242 transmembrane protein 242
TRAK1 trafficking protein, kinesin binding 1
TRIM3 tripartite motif containing 3
TWISTNB TWIST neighbor
VAC14 Vac14 homolog (S. cerevisiae)
ZCCHC14 zinc finger, CCHC domain containing 14
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
ADGRE5 adhesion G protein-coupled receptor E5
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
ARMC4 armadillo repeat containing 4
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
C17ORF80 chromosome 17 open reading frame 80
C19ORF40 chromosome 19 open reading frame 40
C1ORF35 chromosome 1 open reading frame 35
C1ORF56 chromosome 1 open reading frame 56
C5AR2 complement component 5a receptor 2
C7ORF43 chromosome 7 open reading frame 43
CA11 carbonic anhydrase XI
CAMK1 calcium/calmodulin-dependent protein kinase I
CCNO cyclin O
CD82 CD82 molecule
CIDEC cell death-inducing DFFA-like effector c
CLCN6 chloride channel, voltage-sensitive 6
CNGB3 cyclic nucleotide gated channel beta 3
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
CORO7 coronin 7
CRYBG3 beta-gamma crystallin domain containing 3
CSTA cystatin A (stefin A)
CTSF cathepsin F
CUL9 cullin 9
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DUSP13 dual specificity phosphatase 13
DVL1 dishevelled segment polarity protein 1
EGFL7 EGF-like-domain, multiple 7
FAM131A family with sequence similarity 131, member A
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GLI3 GLI family zinc finger 3
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPR87 G protein-coupled receptor 87
GRPR gastrin-releasing peptide receptor
HDAC5 histone deacetylase 5
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HIST1H2AM histone cluster 1, H2am
HPN hepsin
HSPA1L heat shock 70kDa protein 1-like
IFT140 intraflagellar transport 140
IGSF1 immunoglobulin superfamily, member 1
IRF1 interferon regulatory factor 1
IRF2BP1 interferon regulatory factor 2 binding protein 1
KLHL26 kelch-like family member 26
LOC642236 FSHD region gene 1 pseudogene
LY6D lymphocyte antigen 6 complex, locus D
MBTD1 mbt domain containing 1
MCOLN1 mucolipin 1
MFAP2 microfibrillar-associated protein 2
MRPL52 mitochondrial ribosomal protein L52
MT1H metallothionein 1H
NCSTN nicastrin
NFE2L3 nuclear factor, erythroid 2-like 3
PADI2 peptidyl arginine deiminase, type II
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6
POM121 POM121 transmembrane nucleoporin
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F
PRMT7 protein arginine methyltransferase 7
PRR15L proline rich 15-like
RAB30 RAB30, member RAS oncogene family
RAB3A RAB3A, member RAS oncogene family
RHBDD3 rhomboid domain containing 3
RNF2 ring finger protein 2
SARS2 seryl-tRNA synthetase 2, mitochondrial
SDC3 syndecan 3
SLIT2 slit homolog 2 (Drosophila)
SND1-IT1 SND1 intronic transcript 1
SREK1IP1 SREK1-interacting protein 1
STAG3L4 stromal antigen 3-like 4 (pseudogene)
SYT17 synaptotagmin XVII
TFF2 trefoil factor 2
THBS3 thrombospondin 3
THRAP3 thyroid hormone receptor associated protein 3
TLR5 toll-like receptor 5
TMCC2 transmembrane and coiled-coil domain family 2
TMEM121 transmembrane protein 121
TMEM177 transmembrane protein 177
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNS2 tensin 2
TRAIP TRAF interacting protein
TRAPPC13 trafficking protein particle complex 13
ULBP2 UL16 binding protein 2
USP20 ubiquitin specific peptidase 20
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZNF211 zinc finger protein 211
ZNF227 zinc finger protein 227
ZNF253 zinc finger protein 253
ZNF8 zinc finger protein 8